Serological Documentation of Maternal Influenza Exposure and Bipolar Disorder in Adult Offspring
Substantial research has documented an association between prenatal exposure to infection and schizophrenia, and this study found serologically documented maternal influenza exposure was also associated with a fivefold greater risk of bipolar disorder, but only with psychotic features. These results...
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| Veröffentlicht in: | The American journal of psychiatry 2014-05, Vol.171 (5), p.557-563 |
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| container_title | The American journal of psychiatry |
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| creator | Canetta, Sarah E. Bao, Yuanyuan Co, Mary Dawn T. Ennis, Francis A. Cruz, John Terajima, Masanori Shen, Ling Kellendonk, Christoph Schaefer, Catherine A. Brown, Alan S. |
| description | Substantial research has documented an association between prenatal exposure to infection and schizophrenia, and this study found serologically documented maternal influenza exposure was also associated with a fivefold greater risk of bipolar disorder, but only with psychotic features. These results may suggest that prenatal influenza is a risk factor for psychosis rather than for a specific psychotic disorder.
ObjectiveThe authors examined whether serologically confirmed maternal exposure to influenza was associated with an increased risk of bipolar disorder in the offspring and with subtypes of bipolar disorder, with and without psychotic features.MethodThe study used a nested case-control design in the Child Health and Development Study birth cohort. In all, 85 individuals with bipolar disorder were identified following extensive ascertainment and diagnostic assessment and matched to 170 comparison subjects in the analysis. Serological documentation of maternal exposure to influenza was determined using the hemagglutination inhibition assay.ResultsNo association was observed between serologically documented maternal exposure to influenza and bipolar disorder in offspring. However, maternal serological influenza exposure was related to a significant fivefold greater risk of bipolar disorder with psychotic features.ConclusionsThe results suggest that maternal influenza exposure may increase the risk for offspring to develop bipolar disorder with psychotic features. Taken together with earlier associations between prenatal influenza exposure and schizophrenia, these results may suggest that prenatal influenza is a risk factor for psychosis rather than for a specific psychotic disorder diagnosis. |
| doi_str_mv | 10.1176/appi.ajp.2013.13070943 |
| format | Article |
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ObjectiveThe authors examined whether serologically confirmed maternal exposure to influenza was associated with an increased risk of bipolar disorder in the offspring and with subtypes of bipolar disorder, with and without psychotic features.MethodThe study used a nested case-control design in the Child Health and Development Study birth cohort. In all, 85 individuals with bipolar disorder were identified following extensive ascertainment and diagnostic assessment and matched to 170 comparison subjects in the analysis. Serological documentation of maternal exposure to influenza was determined using the hemagglutination inhibition assay.ResultsNo association was observed between serologically documented maternal exposure to influenza and bipolar disorder in offspring. However, maternal serological influenza exposure was related to a significant fivefold greater risk of bipolar disorder with psychotic features.ConclusionsThe results suggest that maternal influenza exposure may increase the risk for offspring to develop bipolar disorder with psychotic features. Taken together with earlier associations between prenatal influenza exposure and schizophrenia, these results may suggest that prenatal influenza is a risk factor for psychosis rather than for a specific psychotic disorder diagnosis.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.2013.13070943</identifier><identifier>PMID: 24480930</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>United States: American Psychiatric Association</publisher><subject>Adult ; Bipolar disorder ; Bipolar Disorder - diagnosis ; Bipolar Disorder - etiology ; Bipolar Disorder - virology ; Case-Control Studies ; Correlation analysis ; Female ; Humans ; Influenza ; Influenza, Human - complications ; Influenza, Human - diagnosis ; Male ; Mental health care ; Middle Aged ; Pregnancy ; Prenatal Exposure Delayed Effects - virology ; Risk Factors</subject><ispartof>The American journal of psychiatry, 2014-05, Vol.171 (5), p.557-563</ispartof><rights>Copyright © 2014 by the American Psychiatric Association 2014</rights><rights>Copyright American Psychiatric Publishing, Inc. May 1, 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a486t-f505b182e09b854b726c146e4926fabc409cedfbfd028216488de207c3a0178b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/appi.ajp.2013.13070943$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/appi.ajp.2013.13070943$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>230,315,781,785,886,2856,21628,21629,21630,27926,27927,77796,77801</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24480930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Canetta, Sarah E.</creatorcontrib><creatorcontrib>Bao, Yuanyuan</creatorcontrib><creatorcontrib>Co, Mary Dawn T.</creatorcontrib><creatorcontrib>Ennis, Francis A.</creatorcontrib><creatorcontrib>Cruz, John</creatorcontrib><creatorcontrib>Terajima, Masanori</creatorcontrib><creatorcontrib>Shen, Ling</creatorcontrib><creatorcontrib>Kellendonk, Christoph</creatorcontrib><creatorcontrib>Schaefer, Catherine A.</creatorcontrib><creatorcontrib>Brown, Alan S.</creatorcontrib><title>Serological Documentation of Maternal Influenza Exposure and Bipolar Disorder in Adult Offspring</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>Substantial research has documented an association between prenatal exposure to infection and schizophrenia, and this study found serologically documented maternal influenza exposure was also associated with a fivefold greater risk of bipolar disorder, but only with psychotic features. These results may suggest that prenatal influenza is a risk factor for psychosis rather than for a specific psychotic disorder.
ObjectiveThe authors examined whether serologically confirmed maternal exposure to influenza was associated with an increased risk of bipolar disorder in the offspring and with subtypes of bipolar disorder, with and without psychotic features.MethodThe study used a nested case-control design in the Child Health and Development Study birth cohort. In all, 85 individuals with bipolar disorder were identified following extensive ascertainment and diagnostic assessment and matched to 170 comparison subjects in the analysis. Serological documentation of maternal exposure to influenza was determined using the hemagglutination inhibition assay.ResultsNo association was observed between serologically documented maternal exposure to influenza and bipolar disorder in offspring. However, maternal serological influenza exposure was related to a significant fivefold greater risk of bipolar disorder with psychotic features.ConclusionsThe results suggest that maternal influenza exposure may increase the risk for offspring to develop bipolar disorder with psychotic features. Taken together with earlier associations between prenatal influenza exposure and schizophrenia, these results may suggest that prenatal influenza is a risk factor for psychosis rather than for a specific psychotic disorder diagnosis.</description><subject>Adult</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - diagnosis</subject><subject>Bipolar Disorder - etiology</subject><subject>Bipolar Disorder - virology</subject><subject>Case-Control Studies</subject><subject>Correlation analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Influenza</subject><subject>Influenza, Human - complications</subject><subject>Influenza, Human - diagnosis</subject><subject>Male</subject><subject>Mental health care</subject><subject>Middle Aged</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - virology</subject><subject>Risk Factors</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1DAURi1ERYeBv1BZYsMm0-tX4myQSlugUlEXUKk74yT24JHHDnZSAb8eT6ctjwULy7Lu8ed7fRA6IrAipKmP9Ti6ld6MKwqErQiDBlrOnqAFEUxUDaXyKVoAAK1awW4O0fOcN-UIrKHP0CHlXELLYIG-fDIp-rh2vfb4LPbz1oRJTy4GHC3-qCeTQqlcBOtnE35qfP59jHlOBusw4LdujF4nfOZyTINJ2AV8Msx-wlfW5jG5sH6BDqz22by835fo-t3559MP1eXV-4vTk8tKc1lPlRUgOiKpgbaTgncNrXvCa8NbWlvd9Rza3gy2swNQSUnNpRwMhaZnGkgjO7ZEb_a549xtzdCXMZL2qvSw1emHitqpvyvBfVXreKs4UNEKUQJe3wek-G02eVJbl3vjvQ4mzlkRQQljjHNW0Ff_oJs47_7pjmItZU1ZS1TvqT7FnJOxj80QUDuJaidRFYlqJ1E9SCwXj_4c5fHag7UCsD1wF_D77f_H_gL54KvG</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Canetta, Sarah E.</creator><creator>Bao, Yuanyuan</creator><creator>Co, Mary Dawn T.</creator><creator>Ennis, Francis A.</creator><creator>Cruz, John</creator><creator>Terajima, Masanori</creator><creator>Shen, Ling</creator><creator>Kellendonk, Christoph</creator><creator>Schaefer, Catherine A.</creator><creator>Brown, Alan S.</creator><general>American Psychiatric Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201405</creationdate><title>Serological Documentation of Maternal Influenza Exposure and Bipolar Disorder in Adult Offspring</title><author>Canetta, Sarah E. ; Bao, Yuanyuan ; Co, Mary Dawn T. ; Ennis, Francis A. ; Cruz, John ; Terajima, Masanori ; Shen, Ling ; Kellendonk, Christoph ; Schaefer, Catherine A. ; Brown, Alan S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a486t-f505b182e09b854b726c146e4926fabc409cedfbfd028216488de207c3a0178b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - diagnosis</topic><topic>Bipolar Disorder - etiology</topic><topic>Bipolar Disorder - virology</topic><topic>Case-Control Studies</topic><topic>Correlation analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Influenza</topic><topic>Influenza, Human - complications</topic><topic>Influenza, Human - diagnosis</topic><topic>Male</topic><topic>Mental health care</topic><topic>Middle Aged</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects - virology</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Canetta, Sarah E.</creatorcontrib><creatorcontrib>Bao, Yuanyuan</creatorcontrib><creatorcontrib>Co, Mary Dawn T.</creatorcontrib><creatorcontrib>Ennis, Francis A.</creatorcontrib><creatorcontrib>Cruz, John</creatorcontrib><creatorcontrib>Terajima, Masanori</creatorcontrib><creatorcontrib>Shen, Ling</creatorcontrib><creatorcontrib>Kellendonk, Christoph</creatorcontrib><creatorcontrib>Schaefer, Catherine A.</creatorcontrib><creatorcontrib>Brown, Alan S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Canetta, Sarah E.</au><au>Bao, Yuanyuan</au><au>Co, Mary Dawn T.</au><au>Ennis, Francis A.</au><au>Cruz, John</au><au>Terajima, Masanori</au><au>Shen, Ling</au><au>Kellendonk, Christoph</au><au>Schaefer, Catherine A.</au><au>Brown, Alan S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serological Documentation of Maternal Influenza Exposure and Bipolar Disorder in Adult Offspring</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>2014-05</date><risdate>2014</risdate><volume>171</volume><issue>5</issue><spage>557</spage><epage>563</epage><pages>557-563</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>Substantial research has documented an association between prenatal exposure to infection and schizophrenia, and this study found serologically documented maternal influenza exposure was also associated with a fivefold greater risk of bipolar disorder, but only with psychotic features. These results may suggest that prenatal influenza is a risk factor for psychosis rather than for a specific psychotic disorder.
ObjectiveThe authors examined whether serologically confirmed maternal exposure to influenza was associated with an increased risk of bipolar disorder in the offspring and with subtypes of bipolar disorder, with and without psychotic features.MethodThe study used a nested case-control design in the Child Health and Development Study birth cohort. In all, 85 individuals with bipolar disorder were identified following extensive ascertainment and diagnostic assessment and matched to 170 comparison subjects in the analysis. Serological documentation of maternal exposure to influenza was determined using the hemagglutination inhibition assay.ResultsNo association was observed between serologically documented maternal exposure to influenza and bipolar disorder in offspring. However, maternal serological influenza exposure was related to a significant fivefold greater risk of bipolar disorder with psychotic features.ConclusionsThe results suggest that maternal influenza exposure may increase the risk for offspring to develop bipolar disorder with psychotic features. Taken together with earlier associations between prenatal influenza exposure and schizophrenia, these results may suggest that prenatal influenza is a risk factor for psychosis rather than for a specific psychotic disorder diagnosis.</abstract><cop>United States</cop><pub>American Psychiatric Association</pub><pmid>24480930</pmid><doi>10.1176/appi.ajp.2013.13070943</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Psychiatric Publishing Journals (1997-Present); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Bipolar disorder Bipolar Disorder - diagnosis Bipolar Disorder - etiology Bipolar Disorder - virology Case-Control Studies Correlation analysis Female Humans Influenza Influenza, Human - complications Influenza, Human - diagnosis Male Mental health care Middle Aged Pregnancy Prenatal Exposure Delayed Effects - virology Risk Factors |
| title | Serological Documentation of Maternal Influenza Exposure and Bipolar Disorder in Adult Offspring |
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