Synthesis and Biochemical Evaluation of Thiochromanone Thiosemicarbazone Analogues as Inhibitors of Cathepsin L

A series of 36 thiosemicarbazone analogues containing the thiochromanone molecular scaffold functionalized primarily at the C-6 position were prepared by chemical synthesis and evaluated as inhibitors of cathepsins L and B. The most promising inhibitors from this group are selective for cathepsin L...

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Veröffentlicht in:	ACS medicinal chemistry letters 2012-06, Vol.3 (6), p.450-453
Hauptverfasser:	Song, Jiangli, Jones, Lindsay M, Kumar, G. D. Kishore, Conner, Elizabeth S, Bayeh, Liela, Chavarria, Gustavo E, Charlton-Sevcik, Amanda K, Chen, Shen-En, Chaplin, David J, Trawick, Mary Lynn, Pinney, Kevin G
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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