Intestinally Targeted Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors Robustly Suppress Postprandial Triglycerides

High DGAT1 expression levels in the small intestine highlight the critical role this enzyme plays in nutrient absorption. Identification of inhibitors which predominantly inhibit DGAT1 in the gut is an attractive drug discovery strategy with anticipated benefits of reduced systemic toxicity. In this...

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Veröffentlicht in:	ACS medicinal chemistry letters 2012-05, Vol.3 (5), p.411-415
Hauptverfasser:	Serrano-Wu, Michael H, Coppola, Gary M, Gong, Yongjin, Neubert, Alan D, Chatelain, Ricardo, Clairmont, Kevin B, Commerford, Renee, Cosker, Theresa, Daniels, Thomas, Hou, Ying, Jain, Monish, Juedes, Marlene, Li, Lisha, Mullarkey, Tara, Rocheford, Erik, Sung, Moo Je, Tyler, Andrew, Yang, Qing, Yoon, Taeyoung, Hubbard, Brian K
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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