Measurement of Atropisomer Racemization Kinetics Using Segmented Flow Technology

When stable atropisomers are encountered by drug discovery teams, they can have important implications due to potential differences in their biological activity, pharmacokinetics, and toxicity. Knowledge of an atropisomer's activation parameters for interconversion is required to facilitate inf...

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Veröffentlicht in:	ACS medicinal chemistry letters 2012-05, Vol.3 (5), p.433-435
Hauptverfasser:	Davoren, Jennifer E, Bundesmann, Mark W, Yan, Qi T, Collantes, Elizabeth M, Mente, Scot, Nason, Deane M, Gray, David L
Format:	Artikel
Sprache:	eng
Schlagworte:	Technology Note
Online-Zugang:	Volltext
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