Reduced genome size of Helicobacter pylori originating from East Asia
Helicobacter pylori(H.pylori),a major pathogen colonizing the human stomach,shows great genetic variation.Comparative analysis of strains from different H.pylori populations revealed that the genome size of strains from East Asia decreased to 1.60 Mbp,which is significantly smaller than that from Eu...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2014-05, Vol.20 (19), p.5666-5671 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Dong, Quan-Jiang Wang, Li-Li Tian, Zi-Bing Yu, Xin-Jun Jia, Sheng-Jiao Xuan, Shi-Ying |
| description | Helicobacter pylori(H.pylori),a major pathogen colonizing the human stomach,shows great genetic variation.Comparative analysis of strains from different H.pylori populations revealed that the genome size of strains from East Asia decreased to 1.60 Mbp,which is significantly smaller than that from Europe or Africa.In parallel with the genome reduction,the number of protein coding genes was decreased,and the guaninecytosine content was lowered to 38.9%.Elimination of non-essential genes by mutations is likely to be a major cause of the genome reduction.Bacteria with a small genome cost less energy.Thus,H.pylori strains from East Asia may have proliferation and growth advantages over those from Western countries.This could result in enhanced capacity of bacterial spreading.Therefore,the reduced genome size potentially contributes to the high prevalence of H.pylori in East Asia. |
| doi_str_mv | 10.3748/wjg.v20.i19.5666 |
| format | Article |
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Wang, Li-Li ; Tian, Zi-Bing ; Yu, Xin-Jun ; Jia, Sheng-Jiao ; Xuan, Shi-Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-52496bb2667a69ccf5acc3566b297eb3d50c3c9b5e8329479a69dbc2359894df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Asia</topic><topic>Epidemiology</topic><topic>Genetic Variation</topic><topic>Genome</topic><topic>Genome Size</topic><topic>Genome, Bacterial</topic><topic>Helicobacter</topic><topic>Helicobacter Infections - epidemiology</topic><topic>Helicobacter Infections - microbiology</topic><topic>Helicobacter pylori - genetics</topic><topic>Humans</topic><topic>Mutation</topic><topic>Phylogeny</topic><topic>Prevalence</topic><topic>pylori</topic><topic>Recombination, Genetic</topic><topic>Stomach - microbiology</topic><topic>Topic Highlight</topic><toplevel>online_resources</toplevel><creatorcontrib>Dong, Quan-Jiang</creatorcontrib><creatorcontrib>Wang, Li-Li</creatorcontrib><creatorcontrib>Tian, Zi-Bing</creatorcontrib><creatorcontrib>Yu, Xin-Jun</creatorcontrib><creatorcontrib>Jia, Sheng-Jiao</creatorcontrib><creatorcontrib>Xuan, Shi-Ying</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong, Quan-Jiang</au><au>Wang, Li-Li</au><au>Tian, Zi-Bing</au><au>Yu, Xin-Jun</au><au>Jia, Sheng-Jiao</au><au>Xuan, Shi-Ying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced genome size of Helicobacter pylori originating from East Asia</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2014-05-21</date><risdate>2014</risdate><volume>20</volume><issue>19</issue><spage>5666</spage><epage>5671</epage><pages>5666-5671</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>Helicobacter pylori(H.pylori),a major pathogen colonizing the human stomach,shows great genetic variation.Comparative analysis of strains from different H.pylori populations revealed that the genome size of strains from East Asia decreased to 1.60 Mbp,which is significantly smaller than that from Europe or Africa.In parallel with the genome reduction,the number of protein coding genes was decreased,and the guaninecytosine content was lowered to 38.9%.Elimination of non-essential genes by mutations is likely to be a major cause of the genome reduction.Bacteria with a small genome cost less energy.Thus,H.pylori strains from East Asia may have proliferation and growth advantages over those from Western countries.This could result in enhanced capacity of bacterial spreading.Therefore,the reduced genome size potentially contributes to the high prevalence of H.pylori in East Asia.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>24914326</pmid><doi>10.3748/wjg.v20.i19.5666</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Asia Epidemiology Genetic Variation Genome Genome Size Genome, Bacterial Helicobacter Helicobacter Infections - epidemiology Helicobacter Infections - microbiology Helicobacter pylori - genetics Humans Mutation Phylogeny Prevalence pylori Recombination, Genetic Stomach - microbiology Topic Highlight |
| title | Reduced genome size of Helicobacter pylori originating from East Asia |
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