Anisomycin Injection in Area CA3 of the Hippocampus Impairs Both Short-Term and Long-Term Memories of Contextual Fear
Protein synthesis is involved in the consolidation of short-term memory into long-term memory. Previous electrophysiological data concerning LTP in CA3 suggest that protein synthesis in that region might also be necessary for short-term memory. We tested this hypothesis by locally injecting the prot...
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| Veröffentlicht in: | Learning & memory (Cold Spring Harbor, N.Y.) N.Y.), 2014-06, Vol.21 (6), p.311-315 |
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| container_title | Learning & memory (Cold Spring Harbor, N.Y.) |
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| creator | Remaud, Jessica Ceccom, Johnatan Carponcy, Julien Dugué, Laura Menchon, Gregory Pech, Stéphane Halley, Helene Francés, Bernard Dahan, Lionel |
| description | Protein synthesis is involved in the consolidation of short-term memory into long-term memory. Previous electrophysiological data concerning LTP in CA3 suggest that protein synthesis in that region might also be necessary for short-term memory. We tested this hypothesis by locally injecting the protein synthesis inhibitor anisomycin in hippocampal area CA1 or CA3 immediately after contextual fear conditioning. As previously shown, injections in CA1 impaired long-term memory but spared short-term memory. Conversely, injections in CA3 impaired both long-term and short-term memories. We conclude that early steps of experience-induced plasticity occurring in CA3 and underlying short-term memory require protein synthesis. |
| doi_str_mv | 10.1101/lm.033969.113 |
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Previous electrophysiological data concerning LTP in CA3 suggest that protein synthesis in that region might also be necessary for short-term memory. We tested this hypothesis by locally injecting the protein synthesis inhibitor anisomycin in hippocampal area CA1 or CA3 immediately after contextual fear conditioning. As previously shown, injections in CA1 impaired long-term memory but spared short-term memory. Conversely, injections in CA3 impaired both long-term and short-term memories. We conclude that early steps of experience-induced plasticity occurring in CA3 and underlying short-term memory require protein synthesis.</description><identifier>ISSN: 1072-0502</identifier><identifier>ISSN: 1549-5485</identifier><identifier>EISSN: 1549-5485</identifier><identifier>DOI: 10.1101/lm.033969.113</identifier><identifier>PMID: 25171422</identifier><language>eng</language><publisher>United States: Cold Spring Harbor Laboratory Press</publisher><subject>Animals ; Anisomycin - pharmacology ; Brain Hemisphere Functions ; Brief Communication ; CA3 Region, Hippocampal - drug effects ; CA3 Region, Hippocampal - metabolism ; Cognitive science ; Cognitive Sciences ; Conditioning ; Conditioning, Classical ; Fear ; Fear - drug effects ; Fear - physiology ; Hypothesis Testing ; Inhibition ; Life Sciences ; Long Term Memory ; Male ; Memory, Long-Term - drug effects ; Memory, Long-Term - physiology ; Memory, Short-Term - drug effects ; Memory, Short-Term - physiology ; Metabolism ; Mice ; Mice, Inbred C57BL ; Neurological Impairments ; Neuronal Plasticity - drug effects ; Neurons and Cognition ; Neuroscience ; Physiology ; Protein Synthesis Inhibitors - pharmacology ; Psychology ; Psychology and behavior ; Short Term Memory</subject><ispartof>Learning & memory (Cold Spring Harbor, N.Y.), 2014-06, Vol.21 (6), p.311-315</ispartof><rights>2014 Remaud et al.; Published by Cold Spring Harbor Laboratory Press.</rights><rights>Attribution - NonCommercial</rights><rights>2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-63fddea69723962d020e3f327d11a38d026b120e0c09620de0d50af97ad89b823</citedby><cites>FETCH-LOGICAL-c542t-63fddea69723962d020e3f327d11a38d026b120e0c09620de0d50af97ad89b823</cites><orcidid>0000-0003-3085-1458</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024620/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024620/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ1035415$$DView record in ERIC$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25171422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://u-paris.hal.science/hal-03344688$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Remaud, Jessica</creatorcontrib><creatorcontrib>Ceccom, Johnatan</creatorcontrib><creatorcontrib>Carponcy, Julien</creatorcontrib><creatorcontrib>Dugué, Laura</creatorcontrib><creatorcontrib>Menchon, Gregory</creatorcontrib><creatorcontrib>Pech, Stéphane</creatorcontrib><creatorcontrib>Halley, Helene</creatorcontrib><creatorcontrib>Francés, Bernard</creatorcontrib><creatorcontrib>Dahan, Lionel</creatorcontrib><title>Anisomycin Injection in Area CA3 of the Hippocampus Impairs Both Short-Term and Long-Term Memories of Contextual Fear</title><title>Learning & memory (Cold Spring Harbor, N.Y.)</title><addtitle>Learn Mem</addtitle><description>Protein synthesis is involved in the consolidation of short-term memory into long-term memory. Previous electrophysiological data concerning LTP in CA3 suggest that protein synthesis in that region might also be necessary for short-term memory. We tested this hypothesis by locally injecting the protein synthesis inhibitor anisomycin in hippocampal area CA1 or CA3 immediately after contextual fear conditioning. As previously shown, injections in CA1 impaired long-term memory but spared short-term memory. Conversely, injections in CA3 impaired both long-term and short-term memories. We conclude that early steps of experience-induced plasticity occurring in CA3 and underlying short-term memory require protein synthesis.</description><subject>Animals</subject><subject>Anisomycin - pharmacology</subject><subject>Brain Hemisphere Functions</subject><subject>Brief Communication</subject><subject>CA3 Region, Hippocampal - drug effects</subject><subject>CA3 Region, Hippocampal - metabolism</subject><subject>Cognitive science</subject><subject>Cognitive Sciences</subject><subject>Conditioning</subject><subject>Conditioning, Classical</subject><subject>Fear</subject><subject>Fear - drug effects</subject><subject>Fear - physiology</subject><subject>Hypothesis Testing</subject><subject>Inhibition</subject><subject>Life Sciences</subject><subject>Long Term Memory</subject><subject>Male</subject><subject>Memory, Long-Term - drug effects</subject><subject>Memory, Long-Term - physiology</subject><subject>Memory, Short-Term - drug effects</subject><subject>Memory, Short-Term - physiology</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neurological Impairments</subject><subject>Neuronal Plasticity - drug effects</subject><subject>Neurons and Cognition</subject><subject>Neuroscience</subject><subject>Physiology</subject><subject>Protein Synthesis Inhibitors - pharmacology</subject><subject>Psychology</subject><subject>Psychology and behavior</subject><subject>Short Term Memory</subject><issn>1072-0502</issn><issn>1549-5485</issn><issn>1549-5485</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkstv1DAQxiMEog84cgT5CIeU8SuPC1K6aruLFnGgnC1vMum6iu1gJxX97_EqZQVcONnfzM-fPZ7JsjcULigF-nGwF8B5XdRJ8mfZKZWizqWo5PO0h5LlIIGdZGcx3gNAWQr6MjthkpZUMHaazY0z0dvH1jiycffYTsY7kkQTUJNVw4nvybRHsjbj6FttxzmSjR21CZFc-mlPvu19mPJbDJZo15Gtd3eL-oLWB4Px4LDybsKf06wHco06vMpe9HqI-PppPc--X1_drtb59uvNZtVs81YKNuUF77sOdVGXLFXIOmCAvOes7CjVvEq62NEUgxZSGjqEToLu61J3Vb2rGD_PPi2-47yz2LXopqAHNQZjdXhUXhv1d8aZvbrzD0oAE8kxGXxYDPb_HFs3W3WIpb8XoqiqB5rY90-XBf9jxjgpa2KLw6Ad-jkqWpSpURXI-v-olJVklSyKhOYL2gYfY8D--AwK6jABarBqmYAkeeLf_Vnykf7d8gS8XQAMpj2mrz5T4FJQyX8Bzwy0Qw</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Remaud, Jessica</creator><creator>Ceccom, Johnatan</creator><creator>Carponcy, Julien</creator><creator>Dugué, Laura</creator><creator>Menchon, Gregory</creator><creator>Pech, Stéphane</creator><creator>Halley, Helene</creator><creator>Francés, Bernard</creator><creator>Dahan, Lionel</creator><general>Cold Spring Harbor Laboratory Press</general><general>CSH Press</general><scope>7SW</scope><scope>BJH</scope><scope>BNH</scope><scope>BNI</scope><scope>BNJ</scope><scope>BNO</scope><scope>ERI</scope><scope>PET</scope><scope>REK</scope><scope>WWN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3085-1458</orcidid></search><sort><creationdate>20140601</creationdate><title>Anisomycin Injection in Area CA3 of the Hippocampus Impairs Both Short-Term and Long-Term Memories of Contextual Fear</title><author>Remaud, Jessica ; 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Previous electrophysiological data concerning LTP in CA3 suggest that protein synthesis in that region might also be necessary for short-term memory. We tested this hypothesis by locally injecting the protein synthesis inhibitor anisomycin in hippocampal area CA1 or CA3 immediately after contextual fear conditioning. As previously shown, injections in CA1 impaired long-term memory but spared short-term memory. Conversely, injections in CA3 impaired both long-term and short-term memories. We conclude that early steps of experience-induced plasticity occurring in CA3 and underlying short-term memory require protein synthesis.</abstract><cop>United States</cop><pub>Cold Spring Harbor Laboratory Press</pub><pmid>25171422</pmid><doi>10.1101/lm.033969.113</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-3085-1458</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Learning & memory (Cold Spring Harbor, N.Y.), 2014-06, Vol.21 (6), p.311-315 |
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| subjects | Animals Anisomycin - pharmacology Brain Hemisphere Functions Brief Communication CA3 Region, Hippocampal - drug effects CA3 Region, Hippocampal - metabolism Cognitive science Cognitive Sciences Conditioning Conditioning, Classical Fear Fear - drug effects Fear - physiology Hypothesis Testing Inhibition Life Sciences Long Term Memory Male Memory, Long-Term - drug effects Memory, Long-Term - physiology Memory, Short-Term - drug effects Memory, Short-Term - physiology Metabolism Mice Mice, Inbred C57BL Neurological Impairments Neuronal Plasticity - drug effects Neurons and Cognition Neuroscience Physiology Protein Synthesis Inhibitors - pharmacology Psychology Psychology and behavior Short Term Memory |
| title | Anisomycin Injection in Area CA3 of the Hippocampus Impairs Both Short-Term and Long-Term Memories of Contextual Fear |
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