Vitreous Substitutes : The Present and the Future
Vitreoretinal surgery has advanced in numerous directions during recent years. The removal of the vitreous body is one of the main characteristics of this surgical procedure. Several molecules have been tested in the past to fill the vitreous cavity and to mimic its functions. We here review the cur...
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| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-12 |
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| creator | Donati, Simone Caprani, Simona Maria Airaghi, Giulia Vinciguerra, Riccardo Bartalena, Luigi Testa, Francesco Mariotti, Cesare Porta, Giovanni Simonelli, Francesca Azzolini, Claudio |
| description | Vitreoretinal surgery has advanced in numerous directions during recent years. The removal of the vitreous body is one of the main characteristics of this surgical procedure. Several molecules have been tested in the past to fill the vitreous cavity and to mimic its functions. We here review the currently available vitreous substitutes, focusing on their molecular properties and functions, together with their adverse effects. Afterwards we describe the characteristics of the ideal vitreous substitute. The challenges facing every ophthalmology researcher are to reach a long-term intraocular permanence of vitreous substitute with total inertness of the molecule injected and the control of inflammatory reactions. We report new polymers with gelification characteristics and smart hydrogels representing the future of vitreoretinal surgery. Finally, we describe the current studies on vitreous regeneration and cell cultures to create new intraocular gels with optimal biocompatibility and rheological properties. |
| doi_str_mv | 10.1155/2014/351804 |
| format | Article |
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The removal of the vitreous body is one of the main characteristics of this surgical procedure. Several molecules have been tested in the past to fill the vitreous cavity and to mimic its functions. We here review the currently available vitreous substitutes, focusing on their molecular properties and functions, together with their adverse effects. Afterwards we describe the characteristics of the ideal vitreous substitute. The challenges facing every ophthalmology researcher are to reach a long-term intraocular permanence of vitreous substitute with total inertness of the molecule injected and the control of inflammatory reactions. We report new polymers with gelification characteristics and smart hydrogels representing the future of vitreoretinal surgery. Finally, we describe the current studies on vitreous regeneration and cell cultures to create new intraocular gels with optimal biocompatibility and rheological properties.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/351804</identifier><identifier>PMID: 24877085</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Analysis ; Anatomy & physiology ; Animals ; Biocompatibility ; Biocompatible Materials ; Bioengineering ; Cataracts ; Diabetic retinopathy ; Forecasts and trends ; Health aspects ; Humans ; Hydrogels ; Medicine ; Molecular structure ; Polyvinyl alcohol ; Prostheses and Implants ; Review ; Stress analysis ; Transplants & implants ; Vitrectomy ; Vitreous Body</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-12</ispartof><rights>Copyright © 2014 Simone Donati et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Simone Donati et al. Simone Donati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Simone Donati et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-7465e48405a03c6bcb3151a1ae83bf97037a89e3d372c9a996c1fb78a314717c3</citedby><cites>FETCH-LOGICAL-c593t-7465e48405a03c6bcb3151a1ae83bf97037a89e3d372c9a996c1fb78a314717c3</cites><orcidid>0000-0002-6920-7021 ; 0000-0002-1334-0974 ; 0000-0002-2280-9981</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024399/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024399/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24877085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Romano, Mario R.</contributor><creatorcontrib>Donati, Simone</creatorcontrib><creatorcontrib>Caprani, Simona Maria</creatorcontrib><creatorcontrib>Airaghi, Giulia</creatorcontrib><creatorcontrib>Vinciguerra, Riccardo</creatorcontrib><creatorcontrib>Bartalena, Luigi</creatorcontrib><creatorcontrib>Testa, Francesco</creatorcontrib><creatorcontrib>Mariotti, Cesare</creatorcontrib><creatorcontrib>Porta, Giovanni</creatorcontrib><creatorcontrib>Simonelli, Francesca</creatorcontrib><creatorcontrib>Azzolini, Claudio</creatorcontrib><title>Vitreous Substitutes : The Present and the Future</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Vitreoretinal surgery has advanced in numerous directions during recent years. The removal of the vitreous body is one of the main characteristics of this surgical procedure. Several molecules have been tested in the past to fill the vitreous cavity and to mimic its functions. We here review the currently available vitreous substitutes, focusing on their molecular properties and functions, together with their adverse effects. Afterwards we describe the characteristics of the ideal vitreous substitute. The challenges facing every ophthalmology researcher are to reach a long-term intraocular permanence of vitreous substitute with total inertness of the molecule injected and the control of inflammatory reactions. We report new polymers with gelification characteristics and smart hydrogels representing the future of vitreoretinal surgery. 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The removal of the vitreous body is one of the main characteristics of this surgical procedure. Several molecules have been tested in the past to fill the vitreous cavity and to mimic its functions. We here review the currently available vitreous substitutes, focusing on their molecular properties and functions, together with their adverse effects. Afterwards we describe the characteristics of the ideal vitreous substitute. The challenges facing every ophthalmology researcher are to reach a long-term intraocular permanence of vitreous substitute with total inertness of the molecule injected and the control of inflammatory reactions. We report new polymers with gelification characteristics and smart hydrogels representing the future of vitreoretinal surgery. 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| subjects | Analysis Anatomy & physiology Animals Biocompatibility Biocompatible Materials Bioengineering Cataracts Diabetic retinopathy Forecasts and trends Health aspects Humans Hydrogels Medicine Molecular structure Polyvinyl alcohol Prostheses and Implants Review Stress analysis Transplants & implants Vitrectomy Vitreous Body |
| title | Vitreous Substitutes : The Present and the Future |
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