Total Synthesis of (±)-Bisabosqual A

The synthesis of the novel squalene synthase inhibitor, bisabosqual A, was completed in 14 steps (longest linear sequence) from commercially available starting materials. The doubly convergent route employs a tandem 5-exo, 6-exo radical cyclization as the key step. This reaction assembles the fully...

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Veröffentlicht in:	Journal of the American Chemical Society 2013-01, Vol.135 (2), p.582-585
Hauptverfasser:	am Ende, Christopher W, Zhou, Zhou, Parker, Kathlyn A
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallography, X-Ray Cyclization Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology esters Farnesyl-Diphosphate Farnesyltransferase - antagonists & inhibitors Heterocyclic Compounds, 4 or More Rings - chemical synthesis Heterocyclic Compounds, 4 or More Rings - chemistry Heterocyclic Compounds, 4 or More Rings - pharmacology Models, Molecular squalene
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