Selective, Retrieval-Independent Disruption of Methamphetamine-Associated Memory by Actin Depolymerization

Background Memories associated with drugs of abuse, such as methamphetamine (METH), increase relapse vulnerability to substance use disorder. There is a growing consensus that memory is supported by structural and functional plasticity driven by F-actin polymerization in postsynaptic dendritic spine...

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Veröffentlicht in:	Biological psychiatry (1969) 2014-01, Vol.75 (2), p.96-104
Hauptverfasser:	Young, Erica J, Aceti, Massimiliano, Griggs, Erica M, Fuchs, Rita A, Zigmond, Zachary, Rumbaugh, Gavin, Miller, Courtney A
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - drug effects Actins - metabolism Addiction amygdala Amygdala - drug effects Animals Biological and medical sciences Bridged Bicyclo Compounds, Heterocyclic - pharmacology Conditioning (Psychology) - drug effects dendritic spine Dendritic Spines - drug effects Electric Stimulation Extinction, Psychological - drug effects Food Heterocyclic Compounds, 4 or More Rings - pharmacology Male Medical sciences Memory - drug effects memory maintenance Mental Recall - drug effects Methamphetamine - administration & dosage Methamphetamine - pharmacology Mice Microinjections myosin Myosin Type II - drug effects Myosin Type II - metabolism Neuronal Plasticity - drug effects Neuropharmacology Pharmacology. Drug treatments Polymerization - drug effects Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Rats Reward Self Administration structural plasticity Thiazolidines - pharmacology
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