SET1 and p300 Act Synergistically, through Coupled Histone Modifications, in Transcriptional Activation by p53

The H3K4me3 mark in chromatin is closely correlated with actively transcribed genes, although the mechanisms involved in its generation and function are not fully understood. In vitro studies with recombinant chromatin and purified human factors demonstrate a robust SET1 complex (SET1C)-mediated H3K...

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Veröffentlicht in:	Cell 2013-07, Vol.154 (2), p.297-310
Hauptverfasser:	Tang, Zhanyun, Chen, Wei-Yi, Shimada, Miho, Nguyen, Uyen T.T., Kim, Jaehoon, Sun, Xiao-Jian, Sengoku, Toru, McGinty, Robert K., Fernandez, Joseph P., Muir, Tom W., Roeder, Robert G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Amino Acid Sequence chromatin Cyclin-Dependent Kinase Inhibitor p21 - metabolism DNA Damage E1A-Associated p300 Protein - metabolism genes HCT116 Cells Histone Code Histone-Lysine N-Methyltransferase - metabolism histones Histones - metabolism Humans in vitro studies Methylation Molecular Sequence Data Multiprotein Complexes - metabolism transcription Transcription, Genetic Transcriptional Activation Tumor Suppressor Protein p53 - metabolism
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