B Cells in Rheumatoid Arthritis : From Pathogenic Players to Disease Biomarkers
The therapeutic benefit of depleting B cells in rheumatoid arthritis (RA) has refocused attention on B cells with increasing awareness on their role in autoimmunity and their function beyond autoantibody production. The rapid increase in our comprehension of B-cell pathobiology is progressively open...
Gespeichert in:
Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-14 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 14 |
---|---|
container_issue | 2014 |
container_start_page | 1 |
container_title | BioMed research international |
container_volume | 2014 |
creator | Bugatti, Serena Vitolo, Barbara Caporali, Roberto Montecucco, Carlomaurizio Manzo, Antonio |
description | The therapeutic benefit of depleting B cells in rheumatoid arthritis (RA) has refocused attention on B cells with increasing awareness on their role in autoimmunity and their function beyond autoantibody production. The rapid increase in our comprehension of B-cell pathobiology is progressively opening novel perspectives in the area of B cell-targeted therapies with the expectation to define more specific approaches able to preserve the homeostasis of the humoral response while disrupting the pathogenic components. In parallel, B-cell activity in RA is starting to be explored in its clinical value, in search of novel biomarkers embedded in the pathogenic process that could help classifying the disease and predicting its heterogeneous outcome beyond inflammation dynamics. In this review, we summarize current knowledge on the multiple roles that B cells play in several aspects of RA. We also analyze their distribution and potential function in different anatomic compartments with specific reference to the main sites in which the disease may be sustained and exert its detrimental effects: the systemic circulation, synovium, bone marrow, and draining lymph nodes. We also highlight novel data encouraging further research in the field of biomarkers related to B cells and their regulatory factors. |
doi_str_mv | 10.1155/2014/681678 |
format | Article |
fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4022166</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A427024027</galeid><sourcerecordid>A427024027</sourcerecordid><originalsourceid>FETCH-LOGICAL-c527t-93787f0b647fb59b962ad2cdb68f4f534cbff8b323347ba7848f8d1eef947d883</originalsourceid><addsrcrecordid>eNqFkU1LxDAURYMoKurKtRJwp4zmq0nqQhhHRwVBEV2HtE2m0bbRpKP4781QHXTl2-TxcjhcuADsYnSMcZadEITZCZeYC7kCNgnFbMQxw6vLndINsBPjM0qTMJTzdbBBmBQCE7EJ7s7hxDRNhK6DD7WZt7r3roLj0NfB9S7CUzgNvoX3uq_9zHSuhPeN_jQhwt7DCxeNjgaeO9_q8JKu22DN6iaane93CzxNLx8n16Pbu6ubyfh2VGZE9KOcCiksKjgTtsjyIudEV6SsCi4tsxllZWGtLCihlIlCC8mklRU2xuZMVFLSLXA2eF_nRWuq0nR90I16DS4F-VReO_X3p3O1mvl3xRAhmPMkOPgWBP82N7FXz34eupRZ4YyJnGBMflEz3RjlOuuTrGxdLNWYEYFI0olEHQ1UGXyMwdhlDozUoia1qEkNNSV6_3f0JftTSgIOB6B2XaU_3D-2vQE2CTFWL2GWI5RT-gU1jaHz</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1547921126</pqid></control><display><type>article</type><title>B Cells in Rheumatoid Arthritis : From Pathogenic Players to Disease Biomarkers</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Bugatti, Serena ; Vitolo, Barbara ; Caporali, Roberto ; Montecucco, Carlomaurizio ; Manzo, Antonio</creator><contributor>Tobón, Gabriel J.</contributor><creatorcontrib>Bugatti, Serena ; Vitolo, Barbara ; Caporali, Roberto ; Montecucco, Carlomaurizio ; Manzo, Antonio ; Tobón, Gabriel J.</creatorcontrib><description>The therapeutic benefit of depleting B cells in rheumatoid arthritis (RA) has refocused attention on B cells with increasing awareness on their role in autoimmunity and their function beyond autoantibody production. The rapid increase in our comprehension of B-cell pathobiology is progressively opening novel perspectives in the area of B cell-targeted therapies with the expectation to define more specific approaches able to preserve the homeostasis of the humoral response while disrupting the pathogenic components. In parallel, B-cell activity in RA is starting to be explored in its clinical value, in search of novel biomarkers embedded in the pathogenic process that could help classifying the disease and predicting its heterogeneous outcome beyond inflammation dynamics. In this review, we summarize current knowledge on the multiple roles that B cells play in several aspects of RA. We also analyze their distribution and potential function in different anatomic compartments with specific reference to the main sites in which the disease may be sustained and exert its detrimental effects: the systemic circulation, synovium, bone marrow, and draining lymph nodes. We also highlight novel data encouraging further research in the field of biomarkers related to B cells and their regulatory factors.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/681678</identifier><identifier>PMID: 24877127</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Animals ; Arthritis, Rheumatoid - immunology ; Arthritis, Rheumatoid - metabolism ; Arthritis, Rheumatoid - pathology ; Autoantibodies - immunology ; Autoantibodies - metabolism ; Autoimmunity ; B-Lymphocytes - immunology ; B-Lymphocytes - metabolism ; B-Lymphocytes - pathology ; Biological markers ; Biomarkers ; Biomarkers - metabolism ; Bone marrow ; Care and treatment ; Cell adhesion & migration ; Chemokines ; Cytokines ; Defects ; Development and progression ; Disease ; Gene expression ; Health aspects ; Humans ; Immune system ; Inflammation - immunology ; Inflammation - metabolism ; Inflammation - pathology ; Lymphocytes ; Medical prognosis ; Pathogenesis ; Patient outcomes ; Plasma ; Review ; Rheumatoid arthritis ; Rheumatology</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-14</ispartof><rights>Copyright © 2014 Serena Bugatti et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Serena Bugatti et al. Serena Bugatti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Serena Bugatti et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-93787f0b647fb59b962ad2cdb68f4f534cbff8b323347ba7848f8d1eef947d883</citedby><cites>FETCH-LOGICAL-c527t-93787f0b647fb59b962ad2cdb68f4f534cbff8b323347ba7848f8d1eef947d883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022166/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022166/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24877127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Tobón, Gabriel J.</contributor><creatorcontrib>Bugatti, Serena</creatorcontrib><creatorcontrib>Vitolo, Barbara</creatorcontrib><creatorcontrib>Caporali, Roberto</creatorcontrib><creatorcontrib>Montecucco, Carlomaurizio</creatorcontrib><creatorcontrib>Manzo, Antonio</creatorcontrib><title>B Cells in Rheumatoid Arthritis : From Pathogenic Players to Disease Biomarkers</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>The therapeutic benefit of depleting B cells in rheumatoid arthritis (RA) has refocused attention on B cells with increasing awareness on their role in autoimmunity and their function beyond autoantibody production. The rapid increase in our comprehension of B-cell pathobiology is progressively opening novel perspectives in the area of B cell-targeted therapies with the expectation to define more specific approaches able to preserve the homeostasis of the humoral response while disrupting the pathogenic components. In parallel, B-cell activity in RA is starting to be explored in its clinical value, in search of novel biomarkers embedded in the pathogenic process that could help classifying the disease and predicting its heterogeneous outcome beyond inflammation dynamics. In this review, we summarize current knowledge on the multiple roles that B cells play in several aspects of RA. We also analyze their distribution and potential function in different anatomic compartments with specific reference to the main sites in which the disease may be sustained and exert its detrimental effects: the systemic circulation, synovium, bone marrow, and draining lymph nodes. We also highlight novel data encouraging further research in the field of biomarkers related to B cells and their regulatory factors.</description><subject>Animals</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Arthritis, Rheumatoid - metabolism</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Autoantibodies - immunology</subject><subject>Autoantibodies - metabolism</subject><subject>Autoimmunity</subject><subject>B-Lymphocytes - immunology</subject><subject>B-Lymphocytes - metabolism</subject><subject>B-Lymphocytes - pathology</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Bone marrow</subject><subject>Care and treatment</subject><subject>Cell adhesion & migration</subject><subject>Chemokines</subject><subject>Cytokines</subject><subject>Defects</subject><subject>Development and progression</subject><subject>Disease</subject><subject>Gene expression</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immune system</subject><subject>Inflammation - immunology</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - pathology</subject><subject>Lymphocytes</subject><subject>Medical prognosis</subject><subject>Pathogenesis</subject><subject>Patient outcomes</subject><subject>Plasma</subject><subject>Review</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatology</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1LxDAURYMoKurKtRJwp4zmq0nqQhhHRwVBEV2HtE2m0bbRpKP4781QHXTl2-TxcjhcuADsYnSMcZadEITZCZeYC7kCNgnFbMQxw6vLndINsBPjM0qTMJTzdbBBmBQCE7EJ7s7hxDRNhK6DD7WZt7r3roLj0NfB9S7CUzgNvoX3uq_9zHSuhPeN_jQhwt7DCxeNjgaeO9_q8JKu22DN6iaane93CzxNLx8n16Pbu6ubyfh2VGZE9KOcCiksKjgTtsjyIudEV6SsCi4tsxllZWGtLCihlIlCC8mklRU2xuZMVFLSLXA2eF_nRWuq0nR90I16DS4F-VReO_X3p3O1mvl3xRAhmPMkOPgWBP82N7FXz34eupRZ4YyJnGBMflEz3RjlOuuTrGxdLNWYEYFI0olEHQ1UGXyMwdhlDozUoia1qEkNNSV6_3f0JftTSgIOB6B2XaU_3D-2vQE2CTFWL2GWI5RT-gU1jaHz</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Bugatti, Serena</creator><creator>Vitolo, Barbara</creator><creator>Caporali, Roberto</creator><creator>Montecucco, Carlomaurizio</creator><creator>Manzo, Antonio</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>B Cells in Rheumatoid Arthritis : From Pathogenic Players to Disease Biomarkers</title><author>Bugatti, Serena ; Vitolo, Barbara ; Caporali, Roberto ; Montecucco, Carlomaurizio ; Manzo, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-93787f0b647fb59b962ad2cdb68f4f534cbff8b323347ba7848f8d1eef947d883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Arthritis, Rheumatoid - metabolism</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>Autoantibodies - immunology</topic><topic>Autoantibodies - metabolism</topic><topic>Autoimmunity</topic><topic>B-Lymphocytes - immunology</topic><topic>B-Lymphocytes - metabolism</topic><topic>B-Lymphocytes - pathology</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Bone marrow</topic><topic>Care and treatment</topic><topic>Cell adhesion & migration</topic><topic>Chemokines</topic><topic>Cytokines</topic><topic>Defects</topic><topic>Development and progression</topic><topic>Disease</topic><topic>Gene expression</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Immune system</topic><topic>Inflammation - immunology</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - pathology</topic><topic>Lymphocytes</topic><topic>Medical prognosis</topic><topic>Pathogenesis</topic><topic>Patient outcomes</topic><topic>Plasma</topic><topic>Review</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bugatti, Serena</creatorcontrib><creatorcontrib>Vitolo, Barbara</creatorcontrib><creatorcontrib>Caporali, Roberto</creatorcontrib><creatorcontrib>Montecucco, Carlomaurizio</creatorcontrib><creatorcontrib>Manzo, Antonio</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bugatti, Serena</au><au>Vitolo, Barbara</au><au>Caporali, Roberto</au><au>Montecucco, Carlomaurizio</au><au>Manzo, Antonio</au><au>Tobón, Gabriel J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>B Cells in Rheumatoid Arthritis : From Pathogenic Players to Disease Biomarkers</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>14</epage><pages>1-14</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>The therapeutic benefit of depleting B cells in rheumatoid arthritis (RA) has refocused attention on B cells with increasing awareness on their role in autoimmunity and their function beyond autoantibody production. The rapid increase in our comprehension of B-cell pathobiology is progressively opening novel perspectives in the area of B cell-targeted therapies with the expectation to define more specific approaches able to preserve the homeostasis of the humoral response while disrupting the pathogenic components. In parallel, B-cell activity in RA is starting to be explored in its clinical value, in search of novel biomarkers embedded in the pathogenic process that could help classifying the disease and predicting its heterogeneous outcome beyond inflammation dynamics. In this review, we summarize current knowledge on the multiple roles that B cells play in several aspects of RA. We also analyze their distribution and potential function in different anatomic compartments with specific reference to the main sites in which the disease may be sustained and exert its detrimental effects: the systemic circulation, synovium, bone marrow, and draining lymph nodes. We also highlight novel data encouraging further research in the field of biomarkers related to B cells and their regulatory factors.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>24877127</pmid><doi>10.1155/2014/681678</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 2314-6133 |
ispartof | BioMed research international, 2014-01, Vol.2014 (2014), p.1-14 |
issn | 2314-6133 2314-6141 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4022166 |
source | MEDLINE; PubMed Central Open Access; Wiley Online Library (Open Access Collection); PubMed Central; Alma/SFX Local Collection |
subjects | Animals Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Autoantibodies - immunology Autoantibodies - metabolism Autoimmunity B-Lymphocytes - immunology B-Lymphocytes - metabolism B-Lymphocytes - pathology Biological markers Biomarkers Biomarkers - metabolism Bone marrow Care and treatment Cell adhesion & migration Chemokines Cytokines Defects Development and progression Disease Gene expression Health aspects Humans Immune system Inflammation - immunology Inflammation - metabolism Inflammation - pathology Lymphocytes Medical prognosis Pathogenesis Patient outcomes Plasma Review Rheumatoid arthritis Rheumatology |
title | B Cells in Rheumatoid Arthritis : From Pathogenic Players to Disease Biomarkers |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-11T11%3A18%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=B%20Cells%20in%20Rheumatoid%20Arthritis%20:%20From%20Pathogenic%20Players%20to%20Disease%20Biomarkers&rft.jtitle=BioMed%20research%20international&rft.au=Bugatti,%20Serena&rft.date=2014-01-01&rft.volume=2014&rft.issue=2014&rft.spage=1&rft.epage=14&rft.pages=1-14&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2014/681678&rft_dat=%3Cgale_pubme%3EA427024027%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1547921126&rft_id=info:pmid/24877127&rft_galeid=A427024027&rfr_iscdi=true |