Anxiety-like behavior of mice produced by conditional central expression of the HIV-1 regulatory protein, Tat

Rationale Human immunodeficiency virus (HIV) infection is associated with substantial increases in generalized anxiety. The HIV regulatory protein, transactivator of transcription (Tat), has been implicated in the neuropathogenesis related to HIV-1 infection. However, direct examination of the effec...

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Veröffentlicht in:	Psychopharmacology 2014-06, Vol.231 (11), p.2349-2360
Hauptverfasser:	Paris, Jason J., Singh, Harminder D., Ganno, Michelle L., Jackson, Pauline, McLaughlin, Jay P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal behavior Animals Anxiety Anxiety Disorders - chemically induced Anxiety Disorders - physiopathology Biomedical and Life Sciences Biomedicine Blotting, Western Brain Brain - drug effects Brain - physiopathology Complications and side effects Development and progression Dose-Response Relationship, Drug Doxycycline - pharmacology Gene Expression - drug effects Genetic aspects HIV HIV infection Human immunodeficiency virus Human immunodeficiency virus 1 Male Mice, Inbred C57BL Mice, Transgenic Neuropsychological Tests Neurosciences Original Investigation Pharmacology/Toxicology Physiological aspects Proteins Psychiatry Psychological aspects Psychotropic Drugs - pharmacology Risk factors Rodents tat Gene Products, Human Immunodeficiency Virus - genetics tat Gene Products, Human Immunodeficiency Virus - metabolism Time Factors Viral proteins
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