PTEN is a potent suppressor of small cell lung cancer

Small cell lung carcinoma (SCLC) is a highly metastatic tumor type with neuroendocrine features and a dismal prognosis. PTEN mutations and PIK3CA activating mutations have been reported in SCLC but the functional relevance of this pathway is unknown. The PTEN/PIK3CA pathway was interrogated using an...

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Veröffentlicht in:	Molecular cancer research 2014-05, Vol.12 (5), p.654-659
Hauptverfasser:	Cui, Min, Augert, Arnaud, Rongione, Michael, Conkrite, Karina, Parazzoli, Susan, Nikitin, Alexander Yu, Ingolia, Nicholas, MacPherson, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Female Genes, Tumor Suppressor Humans Lung Neoplasms - enzymology Lung Neoplasms - genetics Male Mice PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Small Cell Lung Carcinoma - enzymology Small Cell Lung Carcinoma - genetics
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