The Carriage Of Multiresistant Bacteria After Travel (COMBAT) prospective cohort study: methodology and design
Antimicrobial resistance (AMR) is one of the major threats to public health around the world. Besides the intense use and misuse of antimicrobial agents as the major force behind the increase in antimicrobial resistance, the exponential increase of international travel may also substantially contrib...
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| Veröffentlicht in: | BMC public health 2014-04, Vol.14 (1), p.410-410, Article 410 |
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| creator | Arcilla, Maris S van Hattem, Jarne M Bootsma, Martin C J van Genderen, Perry J Goorhuis, Abraham Schultsz, Constance Stobberingh, Ellen E Verbrugh, Henri A de Jong, Menno D Melles, Damian C Penders, John |
| description | Antimicrobial resistance (AMR) is one of the major threats to public health around the world. Besides the intense use and misuse of antimicrobial agents as the major force behind the increase in antimicrobial resistance, the exponential increase of international travel may also substantially contribute to the emergence and spread of AMR. However, knowledge on the extent to which international travel contributes to this is still limited. The Carriage Of Multiresistant Bacteria After Travel (COMBAT) study aims to 1. determine the acquisition rate of multiresistant Enterobacteriaceae during foreign travel 2. ascertain the duration of carriage of these micro-organisms 3. determine the transmission rate within households 4. identify risk factors for acquisition, persistence of carriage and transmission of multiresistant Enterobacteriaceae.
The COMBAT-study is a large-scale multicenter longitudinal cohort study among travellers (n = 2001) and their non-travelling household members (n = 215). Faecal samples are collected before and immediately after travel and 1 month after return from all participants. Follow-up faecal samples are collected 3, 6 and 12 months after return from travellers (and their non-travelling household members) who acquired multiresistant Enterobacteriaceae. Questionnaires are collected from all participants at each time-point. Faecal samples are screened phenotypically for the presence of extended-spectrum beta-lactamase (ESBL) or carbapenemase-producing Enterobacteriaceae. Positive post-travel isolates from travellers with negative pre-travel samples are genotypically analysed for ESBL and carbapenemase genes with microarray and gene sequencing.
The design and scale of the COMBAT-study will enable us to provide much needed detailed insights into the risks and dynamics of introduction and spread of ESBL- and carbapenemase-producing Enterobacteriaceae by healthy travellers and the potential need and measures to monitor or manage these risks.
The study is registered at clinicaltrials.gov under accession number NCT01676974. |
| doi_str_mv | 10.1186/1471-2458-14-410 |
| format | Article |
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The COMBAT-study is a large-scale multicenter longitudinal cohort study among travellers (n = 2001) and their non-travelling household members (n = 215). Faecal samples are collected before and immediately after travel and 1 month after return from all participants. Follow-up faecal samples are collected 3, 6 and 12 months after return from travellers (and their non-travelling household members) who acquired multiresistant Enterobacteriaceae. Questionnaires are collected from all participants at each time-point. Faecal samples are screened phenotypically for the presence of extended-spectrum beta-lactamase (ESBL) or carbapenemase-producing Enterobacteriaceae. Positive post-travel isolates from travellers with negative pre-travel samples are genotypically analysed for ESBL and carbapenemase genes with microarray and gene sequencing.
The design and scale of the COMBAT-study will enable us to provide much needed detailed insights into the risks and dynamics of introduction and spread of ESBL- and carbapenemase-producing Enterobacteriaceae by healthy travellers and the potential need and measures to monitor or manage these risks.
The study is registered at clinicaltrials.gov under accession number NCT01676974.</description><identifier>ISSN: 1471-2458</identifier><identifier>EISSN: 1471-2458</identifier><identifier>DOI: 10.1186/1471-2458-14-410</identifier><identifier>PMID: 24775515</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analysis ; Bacterial Proteins - metabolism ; Beta lactamases ; beta-Lactamases - metabolism ; Cohort Studies ; Drug resistance in microorganisms ; Drug Resistance, Bacterial ; Enterobacteriaceae ; Enterobacteriaceae - isolation & purification ; Enterobacteriaceae - metabolism ; Enterobacteriaceae Infections - epidemiology ; Enterobacteriaceae Infections - microbiology ; Enterobacteriaceae Infections - prevention & control ; Epidemiology ; Feces - microbiology ; Female ; Genes ; Health aspects ; Households ; Humans ; Longitudinal Studies ; Male ; Medical research ; Methods ; Middle Aged ; Netherlands - epidemiology ; Plasmids ; Prospective Studies ; Risk Factors ; Study Protocol ; Surveys and Questionnaires ; Travel ; Travelers</subject><ispartof>BMC public health, 2014-04, Vol.14 (1), p.410-410, Article 410</ispartof><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>2014 Arcilla et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>Copyright © 2014 Arcilla et al.; licensee BioMed Central Ltd. 2014 Arcilla et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b650t-64e9d314a94ba7b2ec9db789ee75ad3491238487c0191db50e1a2b9dedb70f283</citedby><cites>FETCH-LOGICAL-b650t-64e9d314a94ba7b2ec9db789ee75ad3491238487c0191db50e1a2b9dedb70f283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020574/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020574/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24775515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arcilla, Maris S</creatorcontrib><creatorcontrib>van Hattem, Jarne M</creatorcontrib><creatorcontrib>Bootsma, Martin C J</creatorcontrib><creatorcontrib>van Genderen, Perry J</creatorcontrib><creatorcontrib>Goorhuis, Abraham</creatorcontrib><creatorcontrib>Schultsz, Constance</creatorcontrib><creatorcontrib>Stobberingh, Ellen E</creatorcontrib><creatorcontrib>Verbrugh, Henri A</creatorcontrib><creatorcontrib>de Jong, Menno D</creatorcontrib><creatorcontrib>Melles, Damian C</creatorcontrib><creatorcontrib>Penders, John</creatorcontrib><title>The Carriage Of Multiresistant Bacteria After Travel (COMBAT) prospective cohort study: methodology and design</title><title>BMC public health</title><addtitle>BMC Public Health</addtitle><description>Antimicrobial resistance (AMR) is one of the major threats to public health around the world. Besides the intense use and misuse of antimicrobial agents as the major force behind the increase in antimicrobial resistance, the exponential increase of international travel may also substantially contribute to the emergence and spread of AMR. However, knowledge on the extent to which international travel contributes to this is still limited. The Carriage Of Multiresistant Bacteria After Travel (COMBAT) study aims to 1. determine the acquisition rate of multiresistant Enterobacteriaceae during foreign travel 2. ascertain the duration of carriage of these micro-organisms 3. determine the transmission rate within households 4. identify risk factors for acquisition, persistence of carriage and transmission of multiresistant Enterobacteriaceae.
The COMBAT-study is a large-scale multicenter longitudinal cohort study among travellers (n = 2001) and their non-travelling household members (n = 215). Faecal samples are collected before and immediately after travel and 1 month after return from all participants. Follow-up faecal samples are collected 3, 6 and 12 months after return from travellers (and their non-travelling household members) who acquired multiresistant Enterobacteriaceae. Questionnaires are collected from all participants at each time-point. Faecal samples are screened phenotypically for the presence of extended-spectrum beta-lactamase (ESBL) or carbapenemase-producing Enterobacteriaceae. Positive post-travel isolates from travellers with negative pre-travel samples are genotypically analysed for ESBL and carbapenemase genes with microarray and gene sequencing.
The design and scale of the COMBAT-study will enable us to provide much needed detailed insights into the risks and dynamics of introduction and spread of ESBL- and carbapenemase-producing Enterobacteriaceae by healthy travellers and the potential need and measures to monitor or manage these risks.
The study is registered at clinicaltrials.gov under accession number NCT01676974.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Bacterial Proteins - metabolism</subject><subject>Beta lactamases</subject><subject>beta-Lactamases - metabolism</subject><subject>Cohort Studies</subject><subject>Drug resistance in microorganisms</subject><subject>Drug Resistance, Bacterial</subject><subject>Enterobacteriaceae</subject><subject>Enterobacteriaceae - isolation & purification</subject><subject>Enterobacteriaceae - metabolism</subject><subject>Enterobacteriaceae Infections - epidemiology</subject><subject>Enterobacteriaceae Infections - microbiology</subject><subject>Enterobacteriaceae Infections - prevention & control</subject><subject>Epidemiology</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Genes</subject><subject>Health aspects</subject><subject>Households</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical research</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Netherlands - epidemiology</subject><subject>Plasmids</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Study Protocol</subject><subject>Surveys and 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Carriage Of Multiresistant Bacteria After Travel (COMBAT) prospective cohort study: methodology and design</title><author>Arcilla, Maris S ; van Hattem, Jarne M ; Bootsma, Martin C J ; van Genderen, Perry J ; Goorhuis, Abraham ; Schultsz, Constance ; Stobberingh, Ellen E ; Verbrugh, Henri A ; de Jong, Menno D ; Melles, Damian C ; Penders, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b650t-64e9d314a94ba7b2ec9db789ee75ad3491238487c0191db50e1a2b9dedb70f283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Bacterial Proteins - metabolism</topic><topic>Beta lactamases</topic><topic>beta-Lactamases - metabolism</topic><topic>Cohort Studies</topic><topic>Drug resistance in microorganisms</topic><topic>Drug Resistance, 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Constance</au><au>Stobberingh, Ellen E</au><au>Verbrugh, Henri A</au><au>de Jong, Menno D</au><au>Melles, Damian C</au><au>Penders, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Carriage Of Multiresistant Bacteria After Travel (COMBAT) prospective cohort study: methodology and design</atitle><jtitle>BMC public health</jtitle><addtitle>BMC Public Health</addtitle><date>2014-04-28</date><risdate>2014</risdate><volume>14</volume><issue>1</issue><spage>410</spage><epage>410</epage><pages>410-410</pages><artnum>410</artnum><issn>1471-2458</issn><eissn>1471-2458</eissn><abstract>Antimicrobial resistance (AMR) is one of the major threats to public health around the world. Besides the intense use and misuse of antimicrobial agents as the major force behind the increase in antimicrobial resistance, the exponential increase of international travel may also substantially contribute to the emergence and spread of AMR. However, knowledge on the extent to which international travel contributes to this is still limited. The Carriage Of Multiresistant Bacteria After Travel (COMBAT) study aims to 1. determine the acquisition rate of multiresistant Enterobacteriaceae during foreign travel 2. ascertain the duration of carriage of these micro-organisms 3. determine the transmission rate within households 4. identify risk factors for acquisition, persistence of carriage and transmission of multiresistant Enterobacteriaceae.
The COMBAT-study is a large-scale multicenter longitudinal cohort study among travellers (n = 2001) and their non-travelling household members (n = 215). Faecal samples are collected before and immediately after travel and 1 month after return from all participants. Follow-up faecal samples are collected 3, 6 and 12 months after return from travellers (and their non-travelling household members) who acquired multiresistant Enterobacteriaceae. Questionnaires are collected from all participants at each time-point. Faecal samples are screened phenotypically for the presence of extended-spectrum beta-lactamase (ESBL) or carbapenemase-producing Enterobacteriaceae. Positive post-travel isolates from travellers with negative pre-travel samples are genotypically analysed for ESBL and carbapenemase genes with microarray and gene sequencing.
The design and scale of the COMBAT-study will enable us to provide much needed detailed insights into the risks and dynamics of introduction and spread of ESBL- and carbapenemase-producing Enterobacteriaceae by healthy travellers and the potential need and measures to monitor or manage these risks.
The study is registered at clinicaltrials.gov under accession number NCT01676974.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>24775515</pmid><doi>10.1186/1471-2458-14-410</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BMC public health, 2014-04, Vol.14 (1), p.410-410, Article 410 |
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| subjects | Adolescent Adult Aged Aged, 80 and over Analysis Bacterial Proteins - metabolism Beta lactamases beta-Lactamases - metabolism Cohort Studies Drug resistance in microorganisms Drug Resistance, Bacterial Enterobacteriaceae Enterobacteriaceae - isolation & purification Enterobacteriaceae - metabolism Enterobacteriaceae Infections - epidemiology Enterobacteriaceae Infections - microbiology Enterobacteriaceae Infections - prevention & control Epidemiology Feces - microbiology Female Genes Health aspects Households Humans Longitudinal Studies Male Medical research Methods Middle Aged Netherlands - epidemiology Plasmids Prospective Studies Risk Factors Study Protocol Surveys and Questionnaires Travel Travelers |
| title | The Carriage Of Multiresistant Bacteria After Travel (COMBAT) prospective cohort study: methodology and design |
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