A Case-Control Study of the Role of Human Papillomavirus in Oesophageal Squamous Cell Carcinoma in Australia
Objective. We investigate the prevalence of human papillomavirus (HPV) in oesophageal squamous cell carcinoma (OSCC) tissues compared to oesophageal tissue from healthy controls, in an Australian cohort. Methods. We conducted a hospital-based case-control study of 99 patients with OSCC and 100 healt...
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| Veröffentlicht in: | Journal of Oncology 2014-01, Vol.2014 (2014), p.20-26 |
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| creator | Barbour, Andrew P. Crowe, Philip J. MacIntyre, Chandini Raina Rahman, Bayzidur Seale, Holly Cummins, Eleanor Tabrizi, Sepehr N. Garland, Suzanne M. Malik, Aisha Segelov, Eva Liyanage, Surabhi S. Moa, Aye |
| description | Objective. We investigate the prevalence of human papillomavirus (HPV) in oesophageal squamous cell carcinoma (OSCC) tissues compared to oesophageal tissue from healthy controls, in an Australian cohort. Methods. We conducted a hospital-based case-control study of 99 patients with OSCC and 100 healthy controls to examine the presence of HPV DNA. Paraffin tissues were tested using the PapType high-risk HPV detection and genotyping kit and with INNO-LiPA HPV Genotyping Extra. The biopsy samples were tested for HPV using a PCR-ELISA method based on the L1 consensus primer set PGMY09-PGMY11. Results. HPV DNA of the oncogenic genotype 16 was detected in 1/99 case specimens, a rate of 1010 per 100,000 (95% CI: 30–5500). All control specimens were negative for HPV. Significantly higher rates of smoking, other aerodigestive cancers, and mortality were seen among cases than controls. A pooled analysis of this study and the only other Australian case-control study found that 9/321 cases and 0/155 controls were positive for HPV. The pooled odds ratio for HPV being a risk factor for OSCC was 9.35 (95% CI: 0.47–190.33). Conclusion. Our results suggest that in this multifactorial cancer HPV may be an additional risk factor; although a larger, better powered study is needed. |
| doi_str_mv | 10.1155/2014/236482 |
| format | Article |
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We investigate the prevalence of human papillomavirus (HPV) in oesophageal squamous cell carcinoma (OSCC) tissues compared to oesophageal tissue from healthy controls, in an Australian cohort. Methods. We conducted a hospital-based case-control study of 99 patients with OSCC and 100 healthy controls to examine the presence of HPV DNA. Paraffin tissues were tested using the PapType high-risk HPV detection and genotyping kit and with INNO-LiPA HPV Genotyping Extra. The biopsy samples were tested for HPV using a PCR-ELISA method based on the L1 consensus primer set PGMY09-PGMY11. Results. HPV DNA of the oncogenic genotype 16 was detected in 1/99 case specimens, a rate of 1010 per 100,000 (95% CI: 30–5500). All control specimens were negative for HPV. Significantly higher rates of smoking, other aerodigestive cancers, and mortality were seen among cases than controls. A pooled analysis of this study and the only other Australian case-control study found that 9/321 cases and 0/155 controls were positive for HPV. The pooled odds ratio for HPV being a risk factor for OSCC was 9.35 (95% CI: 0.47–190.33). Conclusion. Our results suggest that in this multifactorial cancer HPV may be an additional risk factor; although a larger, better powered study is needed.</description><identifier>ISSN: 1687-8450</identifier><identifier>EISSN: 1687-8450</identifier><identifier>DOI: 10.1155/2014/236482</identifier><identifier>PMID: 24872815</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Limiteds</publisher><subject>Automation ; Biopsy ; Cancer ; Complications and side effects ; Deoxyribonucleic acid ; Development and progression ; DNA ; Endoscopy ; Esophageal cancer ; Genetic aspects ; Human papillomavirus ; Laboratories ; Papillomavirus infections ; Risk factors ; Squamous cell carcinoma</subject><ispartof>Journal of Oncology, 2014-01, Vol.2014 (2014), p.20-26</ispartof><rights>Copyright © 2014 Surabhi S. Liyanage et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Surabhi S. Liyanage et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2014 Surabhi S. Liyanage et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a562t-234058595f1030e35cb1d5b9a484ad88ec9449bf68f8d9791a2e9385316f6cdf3</citedby><cites>FETCH-LOGICAL-a562t-234058595f1030e35cb1d5b9a484ad88ec9449bf68f8d9791a2e9385316f6cdf3</cites><orcidid>0000-0002-6293-9043 ; 0000-0002-4410-6144 ; 0000-0003-4274-6241 ; 0000-0002-1877-5395</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020305/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020305/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24872815$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Schneider, Paul Magnus</contributor><contributor>Paul Magnus Schneider</contributor><creatorcontrib>Barbour, Andrew P.</creatorcontrib><creatorcontrib>Crowe, Philip J.</creatorcontrib><creatorcontrib>MacIntyre, Chandini Raina</creatorcontrib><creatorcontrib>Rahman, Bayzidur</creatorcontrib><creatorcontrib>Seale, Holly</creatorcontrib><creatorcontrib>Cummins, Eleanor</creatorcontrib><creatorcontrib>Tabrizi, Sepehr N.</creatorcontrib><creatorcontrib>Garland, Suzanne M.</creatorcontrib><creatorcontrib>Malik, Aisha</creatorcontrib><creatorcontrib>Segelov, Eva</creatorcontrib><creatorcontrib>Liyanage, Surabhi S.</creatorcontrib><creatorcontrib>Moa, Aye</creatorcontrib><title>A Case-Control Study of the Role of Human Papillomavirus in Oesophageal Squamous Cell Carcinoma in Australia</title><title>Journal of Oncology</title><addtitle>J Oncol</addtitle><description>Objective. We investigate the prevalence of human papillomavirus (HPV) in oesophageal squamous cell carcinoma (OSCC) tissues compared to oesophageal tissue from healthy controls, in an Australian cohort. Methods. We conducted a hospital-based case-control study of 99 patients with OSCC and 100 healthy controls to examine the presence of HPV DNA. Paraffin tissues were tested using the PapType high-risk HPV detection and genotyping kit and with INNO-LiPA HPV Genotyping Extra. The biopsy samples were tested for HPV using a PCR-ELISA method based on the L1 consensus primer set PGMY09-PGMY11. Results. HPV DNA of the oncogenic genotype 16 was detected in 1/99 case specimens, a rate of 1010 per 100,000 (95% CI: 30–5500). All control specimens were negative for HPV. Significantly higher rates of smoking, other aerodigestive cancers, and mortality were seen among cases than controls. A pooled analysis of this study and the only other Australian case-control study found that 9/321 cases and 0/155 controls were positive for HPV. The pooled odds ratio for HPV being a risk factor for OSCC was 9.35 (95% CI: 0.47–190.33). Conclusion. Our results suggest that in this multifactorial cancer HPV may be an additional risk factor; although a larger, better powered study is needed.</description><subject>Automation</subject><subject>Biopsy</subject><subject>Cancer</subject><subject>Complications and side effects</subject><subject>Deoxyribonucleic acid</subject><subject>Development and progression</subject><subject>DNA</subject><subject>Endoscopy</subject><subject>Esophageal cancer</subject><subject>Genetic aspects</subject><subject>Human papillomavirus</subject><subject>Laboratories</subject><subject>Papillomavirus infections</subject><subject>Risk factors</subject><subject>Squamous cell carcinoma</subject><issn>1687-8450</issn><issn>1687-8450</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkUtv1DAURiMEoqWwYo8isUGgUL9jb5BGEVBQpVY81tadxJlx5dhTOynqv8chpTN0xcqv43P9-RbFS4zeY8z5KUGYnRIqmCSPimMsZF1JxtHjg_lR8SylK4QEQ0o8LY4IkzWRmB8XblU2kEzVBD_G4Mrv49TdlqEvx60pvwVn5vnZNIAvL2FnnQsD3Ng4pdL68sKksNvCxkC-eD3BEPJ-Y5zLzthan9kZW01pjOAsPC-e9OCSeXE3nhQ_P3380ZxV5xefvzSr8wq4IGNFKENccsV7jCgylLdr3PG1AiYZdFKaVjGm1r2QvexUrTAQo6jkFItetF1PT4oPi3c3rQfTtcbP9fUu2gHirQ5g9b8n3m71JtxohkiuyLPgzZ0ghuvJpFEPNrU5GHiTM2rMKVK8lpRk9PUD9CpM0ed4mjBUC8oVZXtqA85o6_uQ67azVK8YwVxITlSm3i1UG0NK0fT3T8ZIz73Wc6_10utMvzpMec_-bW4G3i7A1voOftn_s5mMmB4OYEYIERn4ugBgox3tPuZl1nA8fxyq_ygx0fstyh8udJb9Bp_LzPM</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Barbour, Andrew P.</creator><creator>Crowe, Philip J.</creator><creator>MacIntyre, Chandini Raina</creator><creator>Rahman, Bayzidur</creator><creator>Seale, Holly</creator><creator>Cummins, Eleanor</creator><creator>Tabrizi, Sepehr N.</creator><creator>Garland, Suzanne M.</creator><creator>Malik, Aisha</creator><creator>Segelov, Eva</creator><creator>Liyanage, Surabhi S.</creator><creator>Moa, Aye</creator><general>Hindawi Limiteds</general><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>188</scope><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6293-9043</orcidid><orcidid>https://orcid.org/0000-0002-4410-6144</orcidid><orcidid>https://orcid.org/0000-0003-4274-6241</orcidid><orcidid>https://orcid.org/0000-0002-1877-5395</orcidid></search><sort><creationdate>20140101</creationdate><title>A Case-Control Study of the Role of Human Papillomavirus in Oesophageal Squamous Cell Carcinoma in Australia</title><author>Barbour, Andrew P. ; Crowe, Philip J. ; MacIntyre, Chandini Raina ; Rahman, Bayzidur ; Seale, Holly ; Cummins, Eleanor ; Tabrizi, Sepehr N. ; Garland, Suzanne M. ; Malik, Aisha ; Segelov, Eva ; Liyanage, Surabhi S. ; Moa, Aye</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a562t-234058595f1030e35cb1d5b9a484ad88ec9449bf68f8d9791a2e9385316f6cdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Automation</topic><topic>Biopsy</topic><topic>Cancer</topic><topic>Complications and side effects</topic><topic>Deoxyribonucleic acid</topic><topic>Development and progression</topic><topic>DNA</topic><topic>Endoscopy</topic><topic>Esophageal cancer</topic><topic>Genetic aspects</topic><topic>Human papillomavirus</topic><topic>Laboratories</topic><topic>Papillomavirus infections</topic><topic>Risk factors</topic><topic>Squamous cell carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barbour, Andrew P.</creatorcontrib><creatorcontrib>Crowe, Philip J.</creatorcontrib><creatorcontrib>MacIntyre, Chandini Raina</creatorcontrib><creatorcontrib>Rahman, Bayzidur</creatorcontrib><creatorcontrib>Seale, Holly</creatorcontrib><creatorcontrib>Cummins, Eleanor</creatorcontrib><creatorcontrib>Tabrizi, Sepehr N.</creatorcontrib><creatorcontrib>Garland, Suzanne M.</creatorcontrib><creatorcontrib>Malik, Aisha</creatorcontrib><creatorcontrib>Segelov, Eva</creatorcontrib><creatorcontrib>Liyanage, Surabhi S.</creatorcontrib><creatorcontrib>Moa, Aye</creatorcontrib><collection>Airiti Library</collection><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barbour, Andrew P.</au><au>Crowe, Philip J.</au><au>MacIntyre, Chandini Raina</au><au>Rahman, Bayzidur</au><au>Seale, Holly</au><au>Cummins, Eleanor</au><au>Tabrizi, Sepehr N.</au><au>Garland, Suzanne M.</au><au>Malik, Aisha</au><au>Segelov, Eva</au><au>Liyanage, Surabhi S.</au><au>Moa, Aye</au><au>Schneider, Paul Magnus</au><au>Paul Magnus Schneider</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Case-Control Study of the Role of Human Papillomavirus in Oesophageal Squamous Cell Carcinoma in Australia</atitle><jtitle>Journal of Oncology</jtitle><addtitle>J Oncol</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>20</spage><epage>26</epage><pages>20-26</pages><issn>1687-8450</issn><eissn>1687-8450</eissn><abstract>Objective. We investigate the prevalence of human papillomavirus (HPV) in oesophageal squamous cell carcinoma (OSCC) tissues compared to oesophageal tissue from healthy controls, in an Australian cohort. Methods. We conducted a hospital-based case-control study of 99 patients with OSCC and 100 healthy controls to examine the presence of HPV DNA. Paraffin tissues were tested using the PapType high-risk HPV detection and genotyping kit and with INNO-LiPA HPV Genotyping Extra. The biopsy samples were tested for HPV using a PCR-ELISA method based on the L1 consensus primer set PGMY09-PGMY11. Results. HPV DNA of the oncogenic genotype 16 was detected in 1/99 case specimens, a rate of 1010 per 100,000 (95% CI: 30–5500). All control specimens were negative for HPV. Significantly higher rates of smoking, other aerodigestive cancers, and mortality were seen among cases than controls. A pooled analysis of this study and the only other Australian case-control study found that 9/321 cases and 0/155 controls were positive for HPV. The pooled odds ratio for HPV being a risk factor for OSCC was 9.35 (95% CI: 0.47–190.33). Conclusion. Our results suggest that in this multifactorial cancer HPV may be an additional risk factor; although a larger, better powered study is needed.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Limiteds</pub><pmid>24872815</pmid><doi>10.1155/2014/236482</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6293-9043</orcidid><orcidid>https://orcid.org/0000-0002-4410-6144</orcidid><orcidid>https://orcid.org/0000-0003-4274-6241</orcidid><orcidid>https://orcid.org/0000-0002-1877-5395</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Automation Biopsy Cancer Complications and side effects Deoxyribonucleic acid Development and progression DNA Endoscopy Esophageal cancer Genetic aspects Human papillomavirus Laboratories Papillomavirus infections Risk factors Squamous cell carcinoma |
| title | A Case-Control Study of the Role of Human Papillomavirus in Oesophageal Squamous Cell Carcinoma in Australia |
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