Glucagon-like peptide-1 receptor activation in the nucleus accumbens core suppresses feeding by increasing glutamatergic AMPA/kainate signaling

Glucagon-like peptide-1 receptor (GLP-1R) activation in the nucleus accumbens (NAc) core is pharmacologically and physiologically relevant for regulating palatable food intake. Here, we assess whether GLP-1R signaling in the NAc core of rats modulates GABAergic medium spiny neurons (MSNs) through pr...

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Veröffentlicht in:	The Journal of neuroscience 2014-05, Vol.34 (20), p.6985-6992
Hauptverfasser:	Mietlicki-Baase, Elizabeth G, Ortinski, Pavel I, Reiner, David J, Sinon, Christopher G, McCutcheon, James E, Pierce, R Christopher, Roitman, Mitchell F, Hayes, Matthew R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dopamine - metabolism Eating - drug effects Eating - physiology Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Glucagon-Like Peptide-1 Receptor Male Miniature Postsynaptic Potentials - drug effects Miniature Postsynaptic Potentials - physiology Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Peptides - pharmacology Rats Rats, Sprague-Dawley Receptors, AMPA - antagonists & inhibitors Receptors, Glucagon - agonists Receptors, Kainic Acid - antagonists & inhibitors Signal Transduction - drug effects Signal Transduction - physiology Venoms - pharmacology
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