Both Decreased and Increased SRPK1 Levels Promote Cancer by Interfering with PHLPP-Mediated Dephosphorylation of Akt

Akt activation is a hallmark of human cancers. Here, we report a critical mechanism for regulation of Akt activity by the splicing kinase SRPK1, a downstream Akt target for transducing growth signals to regulate splicing. Surprisingly, we find that SRPK1 has a tumor suppressor function because ablat...

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Veröffentlicht in:	Molecular cell 2014-05, Vol.54 (3), p.378-391
Hauptverfasser:	Wang, Pingping, Zhou, Zhihong, Hu, Anchang, Ponte de Albuquerque, Claudio, Zhou, Yu, Hong, Lixin, Sierecki, Emma, Ajiro, Masahiko, Kruhlak, Michael, Harris, Curtis, Guan, Kun-Liang, Zheng, Zhi-Ming, Newton, Alexandra C., Sun, Peiqing, Zhou, Huilin, Fu, Xiang-Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinogenesis - metabolism Cell Adhesion Cells, Cultured Cellular Senescence Colonic Neoplasms - enzymology Colonic Neoplasms - pathology dephosphorylation Enzyme Activation Female fibroblasts gene expression regulation Humans Male Mice Mice, 129 Strain Mice, Knockout Mice, Nude Neoplasm Transplantation neoplasms Nuclear Proteins - metabolism phenotype Phosphoprotein Phosphatases - metabolism Phosphorylation pleckstrin Protein Processing, Post-Translational Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism proteomics Proto-Oncogene Proteins c-akt - metabolism Tumor Burden
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