The Comparative Effectiveness of Prednisolone and Dexamethasone for Children With Croup: A Community-Based Randomized Trial
Background. Although common practice, evidence to support treatment of croup with prednisolone is scant. Methods. We conducted a community-based randomized trial to compare the effectiveness of prednisolone (2 mg/kg/d for 3 days, n = 41) versus 1 dose of dexamethasone (0.6 mg/kg) and 2 doses of plac...
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| Veröffentlicht in: | Clinical pediatrics 2013-11, Vol.52 (11), p.1014-1021 |
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| container_title | Clinical pediatrics |
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| creator | Garbutt, Jane M. Conlon, Bridget Sterkel, Randall Baty, Jack Schechtman, Kenneth B. Mandrell, Kathy Leege, Erin Gentry, Shannon Stunk, Robert C. |
| description | Background. Although common practice, evidence to support treatment of croup with prednisolone is scant. Methods. We conducted a community-based randomized trial to compare the effectiveness of prednisolone (2 mg/kg/d for 3 days, n = 41) versus 1 dose of dexamethasone (0.6 mg/kg) and 2 doses of placebo (n = 46). Participants were children 1 to 8 years old with croup symptoms ≤48 hours, categorized as mild (42%) or moderate (58%). Results. There were no differences for those treated with dexamethasone or prednisolone for additional health care for croup (2% vs 7%, P = .34), duration of croup symptoms (2.8 vs 2.2 days, P = .63), nonbarky cough (6.1 vs 5.9 days, P = .81), nights with disturbed sleep for the parent (0.68 vs 1.21 nights, P = .55), and days with stress (1.39 vs 1.56 days, P = .51). Conclusion. There were no detected differences in outcomes between the 2 croup treatments for either child or parent. |
| doi_str_mv | 10.1177/0009922813504823 |
| format | Article |
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Although common practice, evidence to support treatment of croup with prednisolone is scant. Methods. We conducted a community-based randomized trial to compare the effectiveness of prednisolone (2 mg/kg/d for 3 days, n = 41) versus 1 dose of dexamethasone (0.6 mg/kg) and 2 doses of placebo (n = 46). Participants were children 1 to 8 years old with croup symptoms ≤48 hours, categorized as mild (42%) or moderate (58%). Results. There were no differences for those treated with dexamethasone or prednisolone for additional health care for croup (2% vs 7%, P = .34), duration of croup symptoms (2.8 vs 2.2 days, P = .63), nonbarky cough (6.1 vs 5.9 days, P = .81), nights with disturbed sleep for the parent (0.68 vs 1.21 nights, P = .55), and days with stress (1.39 vs 1.56 days, P = .51). Conclusion. There were no detected differences in outcomes between the 2 croup treatments for either child or parent.</description><identifier>ISSN: 0009-9228</identifier><identifier>EISSN: 1938-2707</identifier><identifier>DOI: 10.1177/0009922813504823</identifier><identifier>PMID: 24092872</identifier><identifier>CODEN: CPEDAM</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Anti-Inflammatory Agents - administration & dosage ; Child, Preschool ; Children & youth ; Clinical trials ; Comparative analysis ; Comparative Effectiveness Research ; Croup - drug therapy ; Dexamethasone - administration & dosage ; Effectiveness studies ; Humans ; Infant ; Pediatrics ; Prednisolone - administration & dosage ; Respiratory diseases ; Treatment Outcome</subject><ispartof>Clinical pediatrics, 2013-11, Vol.52 (11), p.1014-1021</ispartof><rights>The Author(s) 2013</rights><rights>Copyright Westminster Publications, Inc. Nov 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c373t-29b6273422a917238ba148f25d679a99c3683e39f733d6f1427d2d3ec93437bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0009922813504823$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0009922813504823$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>230,314,776,780,881,21799,27903,27904,43600,43601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24092872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garbutt, Jane M.</creatorcontrib><creatorcontrib>Conlon, Bridget</creatorcontrib><creatorcontrib>Sterkel, Randall</creatorcontrib><creatorcontrib>Baty, Jack</creatorcontrib><creatorcontrib>Schechtman, Kenneth B.</creatorcontrib><creatorcontrib>Mandrell, Kathy</creatorcontrib><creatorcontrib>Leege, Erin</creatorcontrib><creatorcontrib>Gentry, Shannon</creatorcontrib><creatorcontrib>Stunk, Robert C.</creatorcontrib><title>The Comparative Effectiveness of Prednisolone and Dexamethasone for Children With Croup: A Community-Based Randomized Trial</title><title>Clinical pediatrics</title><addtitle>Clin Pediatr (Phila)</addtitle><description>Background. Although common practice, evidence to support treatment of croup with prednisolone is scant. Methods. We conducted a community-based randomized trial to compare the effectiveness of prednisolone (2 mg/kg/d for 3 days, n = 41) versus 1 dose of dexamethasone (0.6 mg/kg) and 2 doses of placebo (n = 46). Participants were children 1 to 8 years old with croup symptoms ≤48 hours, categorized as mild (42%) or moderate (58%). Results. There were no differences for those treated with dexamethasone or prednisolone for additional health care for croup (2% vs 7%, P = .34), duration of croup symptoms (2.8 vs 2.2 days, P = .63), nonbarky cough (6.1 vs 5.9 days, P = .81), nights with disturbed sleep for the parent (0.68 vs 1.21 nights, P = .55), and days with stress (1.39 vs 1.56 days, P = .51). Conclusion. There were no detected differences in outcomes between the 2 croup treatments for either child or parent.</description><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Clinical trials</subject><subject>Comparative analysis</subject><subject>Comparative Effectiveness Research</subject><subject>Croup - drug therapy</subject><subject>Dexamethasone - administration & dosage</subject><subject>Effectiveness studies</subject><subject>Humans</subject><subject>Infant</subject><subject>Pediatrics</subject><subject>Prednisolone - administration & dosage</subject><subject>Respiratory diseases</subject><subject>Treatment Outcome</subject><issn>0009-9228</issn><issn>1938-2707</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFP3DAQha2qVdkuvXNClnrpJa3t8cbxBQml0FZCag8gjpY3HpOgxF7sBLX_nkRLESD1ZMvvmzeeN4QccfaFc6W-Msa0FqLisGGyEvCGrLiGqhCKqbdktcjFoh-QDznfMsaBbeA9ORCSaVEpsSLXly3SOg47m-zY3SM98x6b5RYwZxo9_Z3QhS7HPgakNjj6Df_YAcfW5uXFx0TrtutdwkCvu7GldYrT7pC887bP-PHxXJOr87PL-kdx8ev7z_r0omhAwVgIvS2FAimE1VwJqLaWy8qLjSuVtlo3UFaAoL0CcKXnUignHGCjQYLaOliTk73vbtoO6BoMY7K92aVusOmvibYzL5XQteYm3hvJ5qS0nA0-PxqkeDdhHs3Q5Qb73gaMUzZcSpBzviBm9NMr9DZOKczjLZTclGJJeE3YnmpSzDmhf_oMZ2bZmnm9tbnk-PkQTwX_1jQDxR7I9gafdf2f4QNy2Z5H</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Garbutt, Jane M.</creator><creator>Conlon, Bridget</creator><creator>Sterkel, Randall</creator><creator>Baty, Jack</creator><creator>Schechtman, Kenneth B.</creator><creator>Mandrell, Kathy</creator><creator>Leege, Erin</creator><creator>Gentry, Shannon</creator><creator>Stunk, Robert C.</creator><general>SAGE Publications</general><general>Westminster Publications, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20131101</creationdate><title>The Comparative Effectiveness of Prednisolone and Dexamethasone for Children With Croup</title><author>Garbutt, Jane M. ; Conlon, Bridget ; Sterkel, Randall ; Baty, Jack ; Schechtman, Kenneth B. ; Mandrell, Kathy ; Leege, Erin ; Gentry, Shannon ; Stunk, Robert C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-29b6273422a917238ba148f25d679a99c3683e39f733d6f1427d2d3ec93437bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Clinical trials</topic><topic>Comparative analysis</topic><topic>Comparative Effectiveness Research</topic><topic>Croup - drug therapy</topic><topic>Dexamethasone - administration & dosage</topic><topic>Effectiveness studies</topic><topic>Humans</topic><topic>Infant</topic><topic>Pediatrics</topic><topic>Prednisolone - administration & dosage</topic><topic>Respiratory diseases</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garbutt, Jane M.</creatorcontrib><creatorcontrib>Conlon, Bridget</creatorcontrib><creatorcontrib>Sterkel, Randall</creatorcontrib><creatorcontrib>Baty, Jack</creatorcontrib><creatorcontrib>Schechtman, Kenneth B.</creatorcontrib><creatorcontrib>Mandrell, Kathy</creatorcontrib><creatorcontrib>Leege, Erin</creatorcontrib><creatorcontrib>Gentry, Shannon</creatorcontrib><creatorcontrib>Stunk, Robert C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garbutt, Jane M.</au><au>Conlon, Bridget</au><au>Sterkel, Randall</au><au>Baty, Jack</au><au>Schechtman, Kenneth B.</au><au>Mandrell, Kathy</au><au>Leege, Erin</au><au>Gentry, Shannon</au><au>Stunk, Robert C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Comparative Effectiveness of Prednisolone and Dexamethasone for Children With Croup: A Community-Based Randomized Trial</atitle><jtitle>Clinical pediatrics</jtitle><addtitle>Clin Pediatr (Phila)</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>52</volume><issue>11</issue><spage>1014</spage><epage>1021</epage><pages>1014-1021</pages><issn>0009-9228</issn><eissn>1938-2707</eissn><coden>CPEDAM</coden><abstract>Background. Although common practice, evidence to support treatment of croup with prednisolone is scant. Methods. We conducted a community-based randomized trial to compare the effectiveness of prednisolone (2 mg/kg/d for 3 days, n = 41) versus 1 dose of dexamethasone (0.6 mg/kg) and 2 doses of placebo (n = 46). Participants were children 1 to 8 years old with croup symptoms ≤48 hours, categorized as mild (42%) or moderate (58%). Results. There were no differences for those treated with dexamethasone or prednisolone for additional health care for croup (2% vs 7%, P = .34), duration of croup symptoms (2.8 vs 2.2 days, P = .63), nonbarky cough (6.1 vs 5.9 days, P = .81), nights with disturbed sleep for the parent (0.68 vs 1.21 nights, P = .55), and days with stress (1.39 vs 1.56 days, P = .51). Conclusion. 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| subjects | Anti-Inflammatory Agents - administration & dosage Child, Preschool Children & youth Clinical trials Comparative analysis Comparative Effectiveness Research Croup - drug therapy Dexamethasone - administration & dosage Effectiveness studies Humans Infant Pediatrics Prednisolone - administration & dosage Respiratory diseases Treatment Outcome |
| title | The Comparative Effectiveness of Prednisolone and Dexamethasone for Children With Croup: A Community-Based Randomized Trial |
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