Metabolic rates associated with membrane fatty acids in mice selected for increased maximal metabolic rate
Aerobic metabolism of vertebrates is linked to membrane fatty acid (FA) composition. Although the membrane pacemaker hypothesis posits that desaturation of FAs accounts for variation in resting or basal metabolic rate (BMR), little is known about the FA profiles that underpin variation in maximal me...
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| Veröffentlicht in: | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Molecular & integrative physiology, 2013-05, Vol.165 (1), p.70-78 |
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| creator | Wone, Bernard W.M. Donovan, Edward R. Cushman, John C. Hayes, Jack P. |
| description | Aerobic metabolism of vertebrates is linked to membrane fatty acid (FA) composition. Although the membrane pacemaker hypothesis posits that desaturation of FAs accounts for variation in resting or basal metabolic rate (BMR), little is known about the FA profiles that underpin variation in maximal metabolic rate (MMR). We examined membrane FA composition of liver and skeletal muscle in mice after seven generations of selection for increased MMR. In both liver and skeletal muscle, unsaturation index did not differ between control and high-MMR mice. We also examined membrane FA composition at the individual-level of variation. In liver, 18:0, 20:3 n-6, 20:4 n-6, and 22:6 n-3 FAs were significant predictors of MMR. In gastrocnemius muscle, 18:2 n-6, 20:4 n-6, and 22:6 n-3 FAs were significant predictors of MMR. In addition, muscle 16:1 n-7, 18:1 n-9, and 22:5 n-3 FAs were significant predictors of BMR, whereas no liver FAs were significant predictors of BMR. Our findings indicate that (i) individual variation in MMR and BMR appears to be linked to membrane FA composition in the skeletal muscle and liver, and (ii) FAs that differ between selected and control lines are involved in pathways that can affect MMR or BMR. |
| doi_str_mv | 10.1016/j.cbpa.2013.02.010 |
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Although the membrane pacemaker hypothesis posits that desaturation of FAs accounts for variation in resting or basal metabolic rate (BMR), little is known about the FA profiles that underpin variation in maximal metabolic rate (MMR). We examined membrane FA composition of liver and skeletal muscle in mice after seven generations of selection for increased MMR. In both liver and skeletal muscle, unsaturation index did not differ between control and high-MMR mice. We also examined membrane FA composition at the individual-level of variation. In liver, 18:0, 20:3 n-6, 20:4 n-6, and 22:6 n-3 FAs were significant predictors of MMR. In gastrocnemius muscle, 18:2 n-6, 20:4 n-6, and 22:6 n-3 FAs were significant predictors of MMR. In addition, muscle 16:1 n-7, 18:1 n-9, and 22:5 n-3 FAs were significant predictors of BMR, whereas no liver FAs were significant predictors of BMR. Our findings indicate that (i) individual variation in MMR and BMR appears to be linked to membrane FA composition in the skeletal muscle and liver, and (ii) FAs that differ between selected and control lines are involved in pathways that can affect MMR or BMR.</description><identifier>ISSN: 1095-6433</identifier><identifier>EISSN: 1531-4332</identifier><identifier>DOI: 10.1016/j.cbpa.2013.02.010</identifier><identifier>PMID: 23422919</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aerobic capacity ; Animals ; Artificial selection ; Basal metabolic rate ; Basal Metabolism ; Body Weight ; Energy Metabolism ; Evolutionary physiology ; Fatty acid ; fatty acids ; Fatty Acids - metabolism ; liver ; Liver - metabolism ; Membranes - metabolism ; Metabolic rate ; Metabolism ; Mice ; Muscle, Skeletal - metabolism ; muscles ; Network analysis ; skeletal muscle</subject><ispartof>Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2013-05, Vol.165 (1), p.70-78</ispartof><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><rights>2012 Elsevier Inc. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-33737632566e81dd7c2ab9168978e3d182f36d7cb3ce7cb99cf0cca4d2335b03</citedby><cites>FETCH-LOGICAL-c512t-33737632566e81dd7c2ab9168978e3d182f36d7cb3ce7cb99cf0cca4d2335b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1095643313000408$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23422919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wone, Bernard W.M.</creatorcontrib><creatorcontrib>Donovan, Edward R.</creatorcontrib><creatorcontrib>Cushman, John C.</creatorcontrib><creatorcontrib>Hayes, Jack P.</creatorcontrib><title>Metabolic rates associated with membrane fatty acids in mice selected for increased maximal metabolic rate</title><title>Comparative biochemistry and physiology. Part A, Molecular & integrative physiology</title><addtitle>Comp Biochem Physiol A Mol Integr Physiol</addtitle><description>Aerobic metabolism of vertebrates is linked to membrane fatty acid (FA) composition. Although the membrane pacemaker hypothesis posits that desaturation of FAs accounts for variation in resting or basal metabolic rate (BMR), little is known about the FA profiles that underpin variation in maximal metabolic rate (MMR). We examined membrane FA composition of liver and skeletal muscle in mice after seven generations of selection for increased MMR. In both liver and skeletal muscle, unsaturation index did not differ between control and high-MMR mice. We also examined membrane FA composition at the individual-level of variation. In liver, 18:0, 20:3 n-6, 20:4 n-6, and 22:6 n-3 FAs were significant predictors of MMR. In gastrocnemius muscle, 18:2 n-6, 20:4 n-6, and 22:6 n-3 FAs were significant predictors of MMR. In addition, muscle 16:1 n-7, 18:1 n-9, and 22:5 n-3 FAs were significant predictors of BMR, whereas no liver FAs were significant predictors of BMR. Our findings indicate that (i) individual variation in MMR and BMR appears to be linked to membrane FA composition in the skeletal muscle and liver, and (ii) FAs that differ between selected and control lines are involved in pathways that can affect MMR or BMR.</description><subject>Aerobic capacity</subject><subject>Animals</subject><subject>Artificial selection</subject><subject>Basal metabolic rate</subject><subject>Basal Metabolism</subject><subject>Body Weight</subject><subject>Energy Metabolism</subject><subject>Evolutionary physiology</subject><subject>Fatty acid</subject><subject>fatty acids</subject><subject>Fatty Acids - metabolism</subject><subject>liver</subject><subject>Liver - metabolism</subject><subject>Membranes - metabolism</subject><subject>Metabolic rate</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Muscle, Skeletal - metabolism</subject><subject>muscles</subject><subject>Network analysis</subject><subject>skeletal muscle</subject><issn>1095-6433</issn><issn>1531-4332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEoh_wBziAj1wSPJ7ESSSEhCoKSEUcKGfLsSetV0m82NlC_z2z2lKVC_hgz4yfeTX2WxQvQFYgQb_ZVG7Y2kpJwEqqSoJ8VBxDg1DWiOoxx7JvSs3JUXGS80byqqF-WhwprJXqoT8uNl9otUOcghPJrpSFzTm6wKEXP8N6LWaah2QXEqNd11thXfBZhEXMwZHINJHbo2NMXHSJbOZstr_CbCfufaj9rHgy2inT87vztLg8_3B59qm8-Prx89n7i9I1oNYSscVWo2q0pg68b52yQw-669uO0EOnRtRcHdAR733vRumcrb1CbAaJp8W7g-x2N8zkHS1rspPZJh4p3Zpog_n7ZgnX5iremFpC16Fmgdd3Ain-2FFezRyyo2niX4i7bKBtsEbdqvb_KEIPLfRKMaoOqEsx50Tj_UQgzd5OszF7O83eTiOVYTu56eXDt9y3_PGPgVcHYLTR2KsUsvn-jRUaKZXqoKmZeHsgiL_8JlAy2QVaHPmQ2DvjY_jXBL8BH0e7wA</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Wone, Bernard W.M.</creator><creator>Donovan, Edward R.</creator><creator>Cushman, John C.</creator><creator>Hayes, Jack P.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20130501</creationdate><title>Metabolic rates associated with membrane fatty acids in mice selected for increased maximal metabolic rate</title><author>Wone, Bernard W.M. ; Donovan, Edward R. ; Cushman, John C. ; Hayes, Jack P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-33737632566e81dd7c2ab9168978e3d182f36d7cb3ce7cb99cf0cca4d2335b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aerobic capacity</topic><topic>Animals</topic><topic>Artificial selection</topic><topic>Basal metabolic rate</topic><topic>Basal Metabolism</topic><topic>Body Weight</topic><topic>Energy Metabolism</topic><topic>Evolutionary physiology</topic><topic>Fatty acid</topic><topic>fatty acids</topic><topic>Fatty Acids - metabolism</topic><topic>liver</topic><topic>Liver - metabolism</topic><topic>Membranes - metabolism</topic><topic>Metabolic rate</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Muscle, Skeletal - metabolism</topic><topic>muscles</topic><topic>Network analysis</topic><topic>skeletal muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wone, Bernard W.M.</creatorcontrib><creatorcontrib>Donovan, Edward R.</creatorcontrib><creatorcontrib>Cushman, John C.</creatorcontrib><creatorcontrib>Hayes, Jack P.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Comparative biochemistry and physiology. Part A, Molecular & integrative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wone, Bernard W.M.</au><au>Donovan, Edward R.</au><au>Cushman, John C.</au><au>Hayes, Jack P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic rates associated with membrane fatty acids in mice selected for increased maximal metabolic rate</atitle><jtitle>Comparative biochemistry and physiology. Part A, Molecular & integrative physiology</jtitle><addtitle>Comp Biochem Physiol A Mol Integr Physiol</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>165</volume><issue>1</issue><spage>70</spage><epage>78</epage><pages>70-78</pages><issn>1095-6433</issn><eissn>1531-4332</eissn><abstract>Aerobic metabolism of vertebrates is linked to membrane fatty acid (FA) composition. Although the membrane pacemaker hypothesis posits that desaturation of FAs accounts for variation in resting or basal metabolic rate (BMR), little is known about the FA profiles that underpin variation in maximal metabolic rate (MMR). We examined membrane FA composition of liver and skeletal muscle in mice after seven generations of selection for increased MMR. In both liver and skeletal muscle, unsaturation index did not differ between control and high-MMR mice. We also examined membrane FA composition at the individual-level of variation. In liver, 18:0, 20:3 n-6, 20:4 n-6, and 22:6 n-3 FAs were significant predictors of MMR. In gastrocnemius muscle, 18:2 n-6, 20:4 n-6, and 22:6 n-3 FAs were significant predictors of MMR. In addition, muscle 16:1 n-7, 18:1 n-9, and 22:5 n-3 FAs were significant predictors of BMR, whereas no liver FAs were significant predictors of BMR. Our findings indicate that (i) individual variation in MMR and BMR appears to be linked to membrane FA composition in the skeletal muscle and liver, and (ii) FAs that differ between selected and control lines are involved in pathways that can affect MMR or BMR.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23422919</pmid><doi>10.1016/j.cbpa.2013.02.010</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aerobic capacity Animals Artificial selection Basal metabolic rate Basal Metabolism Body Weight Energy Metabolism Evolutionary physiology Fatty acid fatty acids Fatty Acids - metabolism liver Liver - metabolism Membranes - metabolism Metabolic rate Metabolism Mice Muscle, Skeletal - metabolism muscles Network analysis skeletal muscle |
| title | Metabolic rates associated with membrane fatty acids in mice selected for increased maximal metabolic rate |
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