Inhibitory GEF Phosphorylation Provides Negative Feedback in the Yeast Polarity Circuit

Cell polarity is critical for the form and function of many cell types. During polarity establishment, cells define a cortical “front” that behaves differently from the rest of the cortex. The front accumulates high levels of the active form of a polarity-determining Rho-family GTPase (Cdc42, Rac, o...

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Veröffentlicht in:	Current biology 2014-03, Vol.24 (7), p.753-759
Hauptverfasser:	Kuo, Chun-Chen, Savage, Natasha S., Chen, Hsin, Wu, Chi-Fang, Zyla, Trevin R., Lew, Daniel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	cdc42 GTP-Binding Protein, Saccharomyces cerevisiae - metabolism Cell Polarity Computer Simulation Feedback, Physiological Guanine Nucleotide Exchange Factors - metabolism Models, Biological Phosphorylation Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - metabolism Signal Transduction
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