Assessment of Partially Deoxygenated Deoxynojirimycin Derivatives as Glucosylceramide Synthase Inhibitors

Glucosylceramide synthase (GCS) is an approved drug target for the treatment of Gaucher disease and is considered as a valid target for combating other human pathologies, including type 2 diabetes. The clinical drug N-butyldeoxynojirimycin (Zavesca) is thought to inhibit through mimicry of its subst...

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Veröffentlicht in:	ACS medicinal chemistry letters 2011-07, Vol.2 (7), p.519-522
Hauptverfasser:	van den Berg, Richard J. B. H. N, Wennekes, Tom, Ghisaidoobe, Amar, Donker-Koopman, Wilma E, Strijland, Anneke, Boot, Rolf G, van der Marel, Gijsbert A, Aerts, Johannes M. F. G, Overkleeft, Herman S
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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