Discovery of a Novel Series of CRTH2 (DP2) Receptor Antagonists Devoid of Carboxylic Acids

Antagonism of the CRTH2 receptor represents a very attractive target for a variety of allergic diseases. Most CRTH2 antagonists known to date possess a carboxylic acid moiety, which is essential for binding. However, potential acid metabolites O-acyl glucuronides might be linked to idiosynchratic to...

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Veröffentlicht in:	ACS medicinal chemistry letters 2011-12, Vol.2 (12), p.938-942
Hauptverfasser:	Crosignani, Stefano, Jorand-Lebrun, Catherine, Campbell, Gordon, Prêtre, Adeline, Grippi-Vallotton, Tania, Quattropani, Anna, Bouscary-Desforges, Gwenaelle, Bombrun, Agnes, Missotten, Marc, Humbert, Yves, Frémaux, Christèle, Pâquet, Mikaël, El Harkani, Kamel, Bradshaw, Charles G, Cleva, Christophe, Abla, Nada, Daff, Hamina, Schott, Olivier, Pittet, Pierre-André, Arrighi, Jean-François, Gaudet, Marilène, Johnson, Zoë
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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