Aryltriflates as a Neglected Moiety in Medicinal Chemistry: A Case Study from a Lead Optimization of CXCL8 Inhibitors

Interleukin-8 and growth related oncogene−α-chemokines (formerly CXCL8 and CXCL1, respectively) mediate chemotaxis of neutrophils to inflammatory sites via interactions with two transmembrane receptors, the type A CXCL8 receptor (CXCR1) and the type B CXCL8 receptor (CXCR2). In a previous work, we p...

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Veröffentlicht in:	ACS medicinal chemistry letters 2011-10, Vol.2 (10), p.768-773
Hauptverfasser:	Moriconi, Alessio, Bigogno, Chiara, Bianchini, Gianluca, Caligiuri, Antonio, Resconi, Anna, Dondio, Massimo G, D’Anniballe, Gaetano, Allegretti, Marcello
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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