Discovery of Benzodiazepine Sulfonamide-Based Bombesin Receptor Subtype 3 Agonists and Their Unusual Chirality

We report herein the discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 (BRS-3) agonists and their unusual chirality. Starting from a high-throughput screening lead, we prepared a series of BRS-3 agonists with improved potency and pharmacokinetic properties, of which compound...

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Veröffentlicht in:	ACS medicinal chemistry letters 2011-12, Vol.2 (12), p.933-937
Hauptverfasser:	Liu, Ping, Lanza, Thomas J, Chioda, Marc, Jones, Carrie, Chobanian, Harry R, Guo, Yan, Chang, Linda, Kelly, Theresa M, Kan, Yanqing, Palyha, Oksana, Guan, Xiao-Ming, Marsh, Donald J, Metzger, Joseph M, Ramsay, Katie, Wang, Sheng-Ping, Strack, Alison M, Miller, Randy, Pang, Jianmei, Lyons, Kathy, Dragovic, Jasminka, Ning, Jian G, Schafer, Wes A, Welch, Christopher J, Gong, Xiaoyi, Gao, Ying-Duo, Hornak, Viktor, Ball, Richard G, Tsou, Nancy, Reitman, Marc L, Wyvratt, Matthew J, Nargund, Ravi P, Lin, Linus S
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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