Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence
Neuroinflammatory signaling pathways in the central nervous system are of current interest as potential pharmacotherapy targets for alcohol dependence. In this study, we examined the ability of ibudilast, a non‐selective phosphodiesterase inhibitor, to reduce alcohol drinking and relapse in alcohol‐...
Gespeichert in:
| Veröffentlicht in: | Addiction biology 2015-01, Vol.20 (1), p.38-42 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 42 |
|---|---|
| container_issue | 1 |
| container_start_page | 38 |
| container_title | Addiction biology |
| container_volume | 20 |
| creator | Bell, Richard L. Lopez, Marcelo F. Cui, Changhai Egli, Mark Johnson, Kirk W. Franklin, Kelle M. Becker, Howard C. |
| description | Neuroinflammatory signaling pathways in the central nervous system are of current interest as potential pharmacotherapy targets for alcohol dependence. In this study, we examined the ability of ibudilast, a non‐selective phosphodiesterase inhibitor, to reduce alcohol drinking and relapse in alcohol‐preferring P rats, high‐alcohol drinking HAD1 rats, and in mice made dependent on alcohol through cycles of alcohol vapor exposure. When administered twice daily, ibudilast reduced alcohol drinking in rats by approximately 50% and reduced drinking by alcohol‐dependent mice at doses which had no effect in non‐dependent mice. These findings support the viability of ibudilast as a possible treatment for alcohol dependence.
In this study, we examined the ability of ibudilast, a non‐selective phosphodiesterase inhibitor, to reduce alcohol drinking and relapse in alcohol‐preferring P rats, high‐alcohol drinking HAD1 rats, and in mice made dependent on alcohol through cycles of alcohol vapor exposure. When administered twice daily, ibudilast reduced alcohol drinking in rats by approximately 50% and reduced drinking by alcohol dependent mice at doses which had no effect in non‐dependent mice. |
| doi_str_mv | 10.1111/adb.12106 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4017009</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3533143531</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5506-225956c38760a3ac9e964b202981b3d0a62967808ecfea71cc39ea1d93231ba93</originalsourceid><addsrcrecordid>eNqNkUtP3TAQhS1UxHvRP1BF6qabgB-xHW8qUd4SLRICwc5y7LlgcOzbOGnLvyfh0tvHCm888nznzMgHofcE75Lx7BnX7BJKsFhBG4QJVRKB8bup5rwUlPB1tJnzA8aESs7W0Dqtxkcq6Aa6PGsG54PJfdGBGyzkwgSb7lMoXOfjo493hY9FO4TezwMUJvrWhKJNDkIu0uwPDXOIDqKFbbQ6MyHDzuu9ha6Pj64OTsvzi5Ozg_3z0nKORUkpV1xYVkuBDTNWgRJVQzFVNWmYw0ZQJWSNa7AzMJJYyxQY4hSjjDRGsS30eeE7H5oWnIXYdyboeTdu2D3pZLz-txP9vb5LP3SFicR4Mvj0atCl7wPkXrc-WwjBREhD1kRUE0cpeQPKlJJ1xemIfvwPfUhDF8efmKi6riouptkf_l5-ufXvZEZgbwH89AGeln2C9RS5HiPXL5Hr_cMvL8WoKBcKn3v4tVSY7lELySTXN99O9O3XQ3l1eVtrxZ4BasKsHw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1638844569</pqid></control><display><type>article</type><title>Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Bell, Richard L. ; Lopez, Marcelo F. ; Cui, Changhai ; Egli, Mark ; Johnson, Kirk W. ; Franklin, Kelle M. ; Becker, Howard C.</creator><creatorcontrib>Bell, Richard L. ; Lopez, Marcelo F. ; Cui, Changhai ; Egli, Mark ; Johnson, Kirk W. ; Franklin, Kelle M. ; Becker, Howard C.</creatorcontrib><description>Neuroinflammatory signaling pathways in the central nervous system are of current interest as potential pharmacotherapy targets for alcohol dependence. In this study, we examined the ability of ibudilast, a non‐selective phosphodiesterase inhibitor, to reduce alcohol drinking and relapse in alcohol‐preferring P rats, high‐alcohol drinking HAD1 rats, and in mice made dependent on alcohol through cycles of alcohol vapor exposure. When administered twice daily, ibudilast reduced alcohol drinking in rats by approximately 50% and reduced drinking by alcohol‐dependent mice at doses which had no effect in non‐dependent mice. These findings support the viability of ibudilast as a possible treatment for alcohol dependence.
In this study, we examined the ability of ibudilast, a non‐selective phosphodiesterase inhibitor, to reduce alcohol drinking and relapse in alcohol‐preferring P rats, high‐alcohol drinking HAD1 rats, and in mice made dependent on alcohol through cycles of alcohol vapor exposure. When administered twice daily, ibudilast reduced alcohol drinking in rats by approximately 50% and reduced drinking by alcohol dependent mice at doses which had no effect in non‐dependent mice.</description><identifier>ISSN: 1355-6215</identifier><identifier>ISSN: 1369-1600</identifier><identifier>EISSN: 1369-1600</identifier><identifier>DOI: 10.1111/adb.12106</identifier><identifier>PMID: 24215262</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Alcohol ; alcohol dependence ; Alcohol Drinking ; alcohol preference ; Alcohol use ; Alcoholism ; Animals ; AV-411 ; Behavior, Animal - drug effects ; Disease Models, Animal ; ethanol ; ibudilast ; Male ; Mice ; MN-166 ; neuroimmune ; phosphodiesterase ; Phosphodiesterase Inhibitors - pharmacology ; Pyridines - pharmacology ; Rats</subject><ispartof>Addiction biology, 2015-01, Vol.20 (1), p.38-42</ispartof><rights>2013 Society for the Study of Addiction</rights><rights>2013 Society for the Study of Addiction.</rights><rights>2015 Society for the Study of Addiction</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5506-225956c38760a3ac9e964b202981b3d0a62967808ecfea71cc39ea1d93231ba93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fadb.12106$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fadb.12106$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24215262$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bell, Richard L.</creatorcontrib><creatorcontrib>Lopez, Marcelo F.</creatorcontrib><creatorcontrib>Cui, Changhai</creatorcontrib><creatorcontrib>Egli, Mark</creatorcontrib><creatorcontrib>Johnson, Kirk W.</creatorcontrib><creatorcontrib>Franklin, Kelle M.</creatorcontrib><creatorcontrib>Becker, Howard C.</creatorcontrib><title>Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence</title><title>Addiction biology</title><addtitle>Addiction Biology</addtitle><description>Neuroinflammatory signaling pathways in the central nervous system are of current interest as potential pharmacotherapy targets for alcohol dependence. In this study, we examined the ability of ibudilast, a non‐selective phosphodiesterase inhibitor, to reduce alcohol drinking and relapse in alcohol‐preferring P rats, high‐alcohol drinking HAD1 rats, and in mice made dependent on alcohol through cycles of alcohol vapor exposure. When administered twice daily, ibudilast reduced alcohol drinking in rats by approximately 50% and reduced drinking by alcohol‐dependent mice at doses which had no effect in non‐dependent mice. These findings support the viability of ibudilast as a possible treatment for alcohol dependence.
In this study, we examined the ability of ibudilast, a non‐selective phosphodiesterase inhibitor, to reduce alcohol drinking and relapse in alcohol‐preferring P rats, high‐alcohol drinking HAD1 rats, and in mice made dependent on alcohol through cycles of alcohol vapor exposure. When administered twice daily, ibudilast reduced alcohol drinking in rats by approximately 50% and reduced drinking by alcohol dependent mice at doses which had no effect in non‐dependent mice.</description><subject>Alcohol</subject><subject>alcohol dependence</subject><subject>Alcohol Drinking</subject><subject>alcohol preference</subject><subject>Alcohol use</subject><subject>Alcoholism</subject><subject>Animals</subject><subject>AV-411</subject><subject>Behavior, Animal - drug effects</subject><subject>Disease Models, Animal</subject><subject>ethanol</subject><subject>ibudilast</subject><subject>Male</subject><subject>Mice</subject><subject>MN-166</subject><subject>neuroimmune</subject><subject>phosphodiesterase</subject><subject>Phosphodiesterase Inhibitors - pharmacology</subject><subject>Pyridines - pharmacology</subject><subject>Rats</subject><issn>1355-6215</issn><issn>1369-1600</issn><issn>1369-1600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtP3TAQhS1UxHvRP1BF6qabgB-xHW8qUd4SLRICwc5y7LlgcOzbOGnLvyfh0tvHCm888nznzMgHofcE75Lx7BnX7BJKsFhBG4QJVRKB8bup5rwUlPB1tJnzA8aESs7W0Dqtxkcq6Aa6PGsG54PJfdGBGyzkwgSb7lMoXOfjo493hY9FO4TezwMUJvrWhKJNDkIu0uwPDXOIDqKFbbQ6MyHDzuu9ha6Pj64OTsvzi5Ozg_3z0nKORUkpV1xYVkuBDTNWgRJVQzFVNWmYw0ZQJWSNa7AzMJJYyxQY4hSjjDRGsS30eeE7H5oWnIXYdyboeTdu2D3pZLz-txP9vb5LP3SFicR4Mvj0atCl7wPkXrc-WwjBREhD1kRUE0cpeQPKlJJ1xemIfvwPfUhDF8efmKi6riouptkf_l5-ufXvZEZgbwH89AGeln2C9RS5HiPXL5Hr_cMvL8WoKBcKn3v4tVSY7lELySTXN99O9O3XQ3l1eVtrxZ4BasKsHw</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Bell, Richard L.</creator><creator>Lopez, Marcelo F.</creator><creator>Cui, Changhai</creator><creator>Egli, Mark</creator><creator>Johnson, Kirk W.</creator><creator>Franklin, Kelle M.</creator><creator>Becker, Howard C.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QG</scope><scope>7T5</scope><scope>7TM</scope><scope>H94</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>201501</creationdate><title>Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence</title><author>Bell, Richard L. ; Lopez, Marcelo F. ; Cui, Changhai ; Egli, Mark ; Johnson, Kirk W. ; Franklin, Kelle M. ; Becker, Howard C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5506-225956c38760a3ac9e964b202981b3d0a62967808ecfea71cc39ea1d93231ba93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Alcohol</topic><topic>alcohol dependence</topic><topic>Alcohol Drinking</topic><topic>alcohol preference</topic><topic>Alcohol use</topic><topic>Alcoholism</topic><topic>Animals</topic><topic>AV-411</topic><topic>Behavior, Animal - drug effects</topic><topic>Disease Models, Animal</topic><topic>ethanol</topic><topic>ibudilast</topic><topic>Male</topic><topic>Mice</topic><topic>MN-166</topic><topic>neuroimmune</topic><topic>phosphodiesterase</topic><topic>Phosphodiesterase Inhibitors - pharmacology</topic><topic>Pyridines - pharmacology</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bell, Richard L.</creatorcontrib><creatorcontrib>Lopez, Marcelo F.</creatorcontrib><creatorcontrib>Cui, Changhai</creatorcontrib><creatorcontrib>Egli, Mark</creatorcontrib><creatorcontrib>Johnson, Kirk W.</creatorcontrib><creatorcontrib>Franklin, Kelle M.</creatorcontrib><creatorcontrib>Becker, Howard C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Animal Behavior Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Addiction biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bell, Richard L.</au><au>Lopez, Marcelo F.</au><au>Cui, Changhai</au><au>Egli, Mark</au><au>Johnson, Kirk W.</au><au>Franklin, Kelle M.</au><au>Becker, Howard C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence</atitle><jtitle>Addiction biology</jtitle><addtitle>Addiction Biology</addtitle><date>2015-01</date><risdate>2015</risdate><volume>20</volume><issue>1</issue><spage>38</spage><epage>42</epage><pages>38-42</pages><issn>1355-6215</issn><issn>1369-1600</issn><eissn>1369-1600</eissn><abstract>Neuroinflammatory signaling pathways in the central nervous system are of current interest as potential pharmacotherapy targets for alcohol dependence. In this study, we examined the ability of ibudilast, a non‐selective phosphodiesterase inhibitor, to reduce alcohol drinking and relapse in alcohol‐preferring P rats, high‐alcohol drinking HAD1 rats, and in mice made dependent on alcohol through cycles of alcohol vapor exposure. When administered twice daily, ibudilast reduced alcohol drinking in rats by approximately 50% and reduced drinking by alcohol‐dependent mice at doses which had no effect in non‐dependent mice. These findings support the viability of ibudilast as a possible treatment for alcohol dependence.
In this study, we examined the ability of ibudilast, a non‐selective phosphodiesterase inhibitor, to reduce alcohol drinking and relapse in alcohol‐preferring P rats, high‐alcohol drinking HAD1 rats, and in mice made dependent on alcohol through cycles of alcohol vapor exposure. When administered twice daily, ibudilast reduced alcohol drinking in rats by approximately 50% and reduced drinking by alcohol dependent mice at doses which had no effect in non‐dependent mice.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24215262</pmid><doi>10.1111/adb.12106</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1355-6215 |
| ispartof | Addiction biology, 2015-01, Vol.20 (1), p.38-42 |
| issn | 1355-6215 1369-1600 1369-1600 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4017009 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Alcohol alcohol dependence Alcohol Drinking alcohol preference Alcohol use Alcoholism Animals AV-411 Behavior, Animal - drug effects Disease Models, Animal ethanol ibudilast Male Mice MN-166 neuroimmune phosphodiesterase Phosphodiesterase Inhibitors - pharmacology Pyridines - pharmacology Rats |
| title | Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T19%3A19%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ibudilast%20reduces%20alcohol%20drinking%20in%20multiple%20animal%20models%20of%20alcohol%20dependence&rft.jtitle=Addiction%20biology&rft.au=Bell,%20Richard%20L.&rft.date=2015-01&rft.volume=20&rft.issue=1&rft.spage=38&rft.epage=42&rft.pages=38-42&rft.issn=1355-6215&rft.eissn=1369-1600&rft_id=info:doi/10.1111/adb.12106&rft_dat=%3Cproquest_pubme%3E3533143531%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1638844569&rft_id=info:pmid/24215262&rfr_iscdi=true |