Endothelial cell-derived interleukin-6 regulates tumor growth

Endothelial cells play a complex role in the pathobiology of cancer. This role is not limited to the making of blood vessels to allow for influx of oxygen and nutrients required for the high metabolic demands of tumor cells. Indeed, it has been recently shown that tumor-associated endothelial cells...

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Veröffentlicht in:	BMC cancer 2014-02, Vol.14 (1), p.99-99, Article 99
Hauptverfasser:	Neiva, Kathleen G, Warner, Kristy A, Campos, Marcia S, Zhang, Zhaocheng, Moren, Juliana, Danciu, Theodora E, Nör, Jacques E
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Cancer therapies Cell culture Cell Line, Tumor Cervical cancer Colleges & universities Culture Media, Conditioned - pharmacology Cytokines Dentistry Disease Models, Animal Endothelial Cells - metabolism Endothelium Extracellular Signal-Regulated MAP Kinases - metabolism Gene Silencing Heterografts Humans Interleukin-6 - genetics Interleukin-6 - metabolism Kinases Male Medical prognosis Mice Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neovascularization, Pathologic - genetics Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Rodents Signal Transduction - drug effects STAT3 Transcription Factor - metabolism Tumor Burden - drug effects Tumor Burden - genetics Tumors
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