Layer-by-layer nanoencapsulation of camptothecin with improved activity

160nm nanocapsules containing up to 60% of camptothecin in the core and 7–8 polyelectrolyte bilayers in the shell were produced by washless layer-by-layer assembly of heparin and block-copolymer of poly-l-lysine and polyethylene glycol. The outer surface of the nanocapsules was additionally modified...

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Veröffentlicht in:	International journal of pharmaceutics 2014-04, Vol.465 (1-2), p.218-227
Hauptverfasser:	Parekh, Gaurav, Pattekari, Pravin, Joshi, Chaitanya, Shutava, Tatsiana, DeCoster, Mark, Levchenko, Tatyana, Torchilin, Vladimir, Lvov, Yuri
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Brain Neoplasms - pathology Camptothecin Camptothecin - chemistry Camptothecin - pharmacology Cell Line, Tumor Cell Survival - drug effects Chemistry, Pharmaceutical Cytotoxic Drug Compounding Drug Stability Glioblastoma Glioblastoma - pathology Heparin - chemistry Hydrogen-Ion Concentration Hydrolysis Kinetics Lactone Layer-by-layer Molecular Weight Nanocapsules Nanotechnology Particle Size Polyethylene Glycols - chemistry Polylysine - chemistry Polymers - chemistry Rats Solubility Technology, Pharmaceutical - methods
Online-Zugang:	Volltext
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