Reproducible Ion-Current-Based Approach for 24-Plex Comparison of the Tissue Proteomes of Hibernating versus Normal Myocardium in Swine Models

Hibernating myocardium is an adaptive response to repetitive myocardial ischemia that is clinically common, but the mechanism of adaptation is poorly understood. Here we compared the proteomes of hibernating versus normal myocardium in a porcine model with 24 biological replicates. Using the ion-cur...

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Veröffentlicht in:	Journal of proteome research 2014-05, Vol.13 (5), p.2571-2584
Hauptverfasser:	Qu, Jun, Young, Rebeccah, Page, Brian J, Shen, Xiaomeng, Tata, Nazneen, Li, Jun, Duan, Xiaotao, Fallavollita, James A, Canty, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - physiology animal models Animals apoptosis cardiomyocytes Chromatography, Liquid contractile proteins cytoskeletal proteins cytoskeleton detergents glycolysis Humans Mass Spectrometry mitochondria Models, Animal myocardial ischemia Myocardial Ischemia - metabolism Myocardial Ischemia - physiopathology Myocardium - metabolism peptides protein synthesis proteome Proteome - metabolism proteomics Proteomics - methods Reproducibility of Results stress response Swine translation (genetics) Two-Dimensional Difference Gel Electrophoresis viability
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