Effects of obstructive sleep apnea and obesity on exercise function in children
Evaluate the relative contributions of weight status and obstructive sleep apnea (OSA) to cardiopulmonary exercise responses in children. Prospective, cross-sectional study. Participants underwent anthropometric measurements, overnight polysomnography, spirometry, cardiopulmonary exercise function t...
Gespeichert in:
Veröffentlicht in: | Sleep (New York, N.Y.) N.Y.), 2014-06, Vol.37 (6), p.1103-1110 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1110 |
---|---|
container_issue | 6 |
container_start_page | 1103 |
container_title | Sleep (New York, N.Y.) |
container_volume | 37 |
creator | Evans, Carla A Selvadurai, Hiran Baur, Louise A Waters, Karen A |
description | Evaluate the relative contributions of weight status and obstructive sleep apnea (OSA) to cardiopulmonary exercise responses in children.
Prospective, cross-sectional study. Participants underwent anthropometric measurements, overnight polysomnography, spirometry, cardiopulmonary exercise function testing on a cycle ergometer, and cardiac doppler imaging. OSA was defined as ≥ 1 obstructive apnea or hypopnea per hour of sleep (OAHI). The effect of OSA on exercise function was evaluated after the parameters were corrected for body mass index (BMI) z-scores. Similarly, the effect of obesity on exercise function was examined when the variables were adjusted for OAHI.
Tertiary pediatric hospital.
Healthy weight and obese children, aged 7-12 y.
N/A.
Seventy-one children were studied. In comparison with weight-matched children without OSA, children with OSA had a lower cardiac output, stroke volume index, heart rate, and oxygen consumption (VO2 peak) at peak exercise capacity. After adjusting for BMI z-score, children with OSA had 1.5 L/min (95% confidence interval -2.3 to -0.6 L/min; P = 0.001) lower cardiac output at peak exercise capacity, but minute ventilation and ventilatory responses to exercise were not affected. Obesity was only associated with physical deconditioning. Cardiac dysfunction was associated with the frequency of respiratory-related arousals, the severity of hypoxia, and heart rate during sleep.
Children with OSA are exercise limited due to a reduced cardiac output and VO2 peak at peak exercise capacity, independent of their weight status. Comorbid OSA can further decrease exercise performance in obese children. |
doi_str_mv | 10.5665/sleep.3770 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4015384</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1531953458</sourcerecordid><originalsourceid>FETCH-LOGICAL-c378t-19ff7aaa000bb00bc2c9daebff007b41ca4ec2da0ca248b6c3b9cc7a9928c40d3</originalsourceid><addsrcrecordid>eNpVkU1LxDAQhoMoun5c_AGSowhdJ22zbS6CLH6B4EXPIZ1ONNJN16Rd3H9v1FX0MAwz8_DO8A5jxwKmcjaT57EjWk6LqoItNhFSQqYEqG02ATETWS1A7rH9GF8h1aUqdtleXtZ1rkBO2MOVtYRD5L3lfROHMOLgVsS_NLlZejLc-DbNKLphzXvP6Z0Cukjcjj7BqeM8xxfXtYH8Iduxpot0tMkH7On66nF-m90_3NzNL-8zLKp6yISytjLGAEDTpMAcVWuosRagakqBpiTMWwNo0q3NDItGIVZGqbzGEtrigF186y7HZkEtkh-C6fQyuIUJa90bp_9PvHvRz_1KlyBkUZdJ4HQjEPq3keKgFy4idZ3x1I9RJ0ooWZSyTujZN4qhjzGQ_V0jQH9-QH-5pT8_kOCTv4f9oj-WFx-FKIVw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1531953458</pqid></control><display><type>article</type><title>Effects of obstructive sleep apnea and obesity on exercise function in children</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Evans, Carla A ; Selvadurai, Hiran ; Baur, Louise A ; Waters, Karen A</creator><creatorcontrib>Evans, Carla A ; Selvadurai, Hiran ; Baur, Louise A ; Waters, Karen A</creatorcontrib><description>Evaluate the relative contributions of weight status and obstructive sleep apnea (OSA) to cardiopulmonary exercise responses in children.
Prospective, cross-sectional study. Participants underwent anthropometric measurements, overnight polysomnography, spirometry, cardiopulmonary exercise function testing on a cycle ergometer, and cardiac doppler imaging. OSA was defined as ≥ 1 obstructive apnea or hypopnea per hour of sleep (OAHI). The effect of OSA on exercise function was evaluated after the parameters were corrected for body mass index (BMI) z-scores. Similarly, the effect of obesity on exercise function was examined when the variables were adjusted for OAHI.
Tertiary pediatric hospital.
Healthy weight and obese children, aged 7-12 y.
N/A.
Seventy-one children were studied. In comparison with weight-matched children without OSA, children with OSA had a lower cardiac output, stroke volume index, heart rate, and oxygen consumption (VO2 peak) at peak exercise capacity. After adjusting for BMI z-score, children with OSA had 1.5 L/min (95% confidence interval -2.3 to -0.6 L/min; P = 0.001) lower cardiac output at peak exercise capacity, but minute ventilation and ventilatory responses to exercise were not affected. Obesity was only associated with physical deconditioning. Cardiac dysfunction was associated with the frequency of respiratory-related arousals, the severity of hypoxia, and heart rate during sleep.
Children with OSA are exercise limited due to a reduced cardiac output and VO2 peak at peak exercise capacity, independent of their weight status. Comorbid OSA can further decrease exercise performance in obese children.</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.5665/sleep.3770</identifier><identifier>PMID: 24882905</identifier><language>eng</language><publisher>United States: Associated Professional Sleep Societies, LLC</publisher><subject>Body Mass Index ; Body Weight ; Cardiac Output ; Child ; Cross-Sectional Studies ; Effects of OSA and Obesity on Exercise Function in Children ; Exercise - physiology ; Exercise Test ; Female ; Heart Rate - physiology ; Humans ; Male ; Obesity - complications ; Obesity - physiopathology ; Polysomnography ; Prospective Studies ; Sleep - physiology ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - physiopathology ; Spirometry</subject><ispartof>Sleep (New York, N.Y.), 2014-06, Vol.37 (6), p.1103-1110</ispartof><rights>2014 Associated Professional Sleep Societies, LLC. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-19ff7aaa000bb00bc2c9daebff007b41ca4ec2da0ca248b6c3b9cc7a9928c40d3</citedby><cites>FETCH-LOGICAL-c378t-19ff7aaa000bb00bc2c9daebff007b41ca4ec2da0ca248b6c3b9cc7a9928c40d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24882905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Evans, Carla A</creatorcontrib><creatorcontrib>Selvadurai, Hiran</creatorcontrib><creatorcontrib>Baur, Louise A</creatorcontrib><creatorcontrib>Waters, Karen A</creatorcontrib><title>Effects of obstructive sleep apnea and obesity on exercise function in children</title><title>Sleep (New York, N.Y.)</title><addtitle>Sleep</addtitle><description>Evaluate the relative contributions of weight status and obstructive sleep apnea (OSA) to cardiopulmonary exercise responses in children.
Prospective, cross-sectional study. Participants underwent anthropometric measurements, overnight polysomnography, spirometry, cardiopulmonary exercise function testing on a cycle ergometer, and cardiac doppler imaging. OSA was defined as ≥ 1 obstructive apnea or hypopnea per hour of sleep (OAHI). The effect of OSA on exercise function was evaluated after the parameters were corrected for body mass index (BMI) z-scores. Similarly, the effect of obesity on exercise function was examined when the variables were adjusted for OAHI.
Tertiary pediatric hospital.
Healthy weight and obese children, aged 7-12 y.
N/A.
Seventy-one children were studied. In comparison with weight-matched children without OSA, children with OSA had a lower cardiac output, stroke volume index, heart rate, and oxygen consumption (VO2 peak) at peak exercise capacity. After adjusting for BMI z-score, children with OSA had 1.5 L/min (95% confidence interval -2.3 to -0.6 L/min; P = 0.001) lower cardiac output at peak exercise capacity, but minute ventilation and ventilatory responses to exercise were not affected. Obesity was only associated with physical deconditioning. Cardiac dysfunction was associated with the frequency of respiratory-related arousals, the severity of hypoxia, and heart rate during sleep.
Children with OSA are exercise limited due to a reduced cardiac output and VO2 peak at peak exercise capacity, independent of their weight status. Comorbid OSA can further decrease exercise performance in obese children.</description><subject>Body Mass Index</subject><subject>Body Weight</subject><subject>Cardiac Output</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Effects of OSA and Obesity on Exercise Function in Children</subject><subject>Exercise - physiology</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Obesity - complications</subject><subject>Obesity - physiopathology</subject><subject>Polysomnography</subject><subject>Prospective Studies</subject><subject>Sleep - physiology</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - physiopathology</subject><subject>Spirometry</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1LxDAQhoMoun5c_AGSowhdJ22zbS6CLH6B4EXPIZ1ONNJN16Rd3H9v1FX0MAwz8_DO8A5jxwKmcjaT57EjWk6LqoItNhFSQqYEqG02ATETWS1A7rH9GF8h1aUqdtleXtZ1rkBO2MOVtYRD5L3lfROHMOLgVsS_NLlZejLc-DbNKLphzXvP6Z0Cukjcjj7BqeM8xxfXtYH8Iduxpot0tMkH7On66nF-m90_3NzNL-8zLKp6yISytjLGAEDTpMAcVWuosRagakqBpiTMWwNo0q3NDItGIVZGqbzGEtrigF186y7HZkEtkh-C6fQyuIUJa90bp_9PvHvRz_1KlyBkUZdJ4HQjEPq3keKgFy4idZ3x1I9RJ0ooWZSyTujZN4qhjzGQ_V0jQH9-QH-5pT8_kOCTv4f9oj-WFx-FKIVw</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Evans, Carla A</creator><creator>Selvadurai, Hiran</creator><creator>Baur, Louise A</creator><creator>Waters, Karen A</creator><general>Associated Professional Sleep Societies, LLC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140601</creationdate><title>Effects of obstructive sleep apnea and obesity on exercise function in children</title><author>Evans, Carla A ; Selvadurai, Hiran ; Baur, Louise A ; Waters, Karen A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-19ff7aaa000bb00bc2c9daebff007b41ca4ec2da0ca248b6c3b9cc7a9928c40d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Body Mass Index</topic><topic>Body Weight</topic><topic>Cardiac Output</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Effects of OSA and Obesity on Exercise Function in Children</topic><topic>Exercise - physiology</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Obesity - complications</topic><topic>Obesity - physiopathology</topic><topic>Polysomnography</topic><topic>Prospective Studies</topic><topic>Sleep - physiology</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - physiopathology</topic><topic>Spirometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Evans, Carla A</creatorcontrib><creatorcontrib>Selvadurai, Hiran</creatorcontrib><creatorcontrib>Baur, Louise A</creatorcontrib><creatorcontrib>Waters, Karen A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Evans, Carla A</au><au>Selvadurai, Hiran</au><au>Baur, Louise A</au><au>Waters, Karen A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of obstructive sleep apnea and obesity on exercise function in children</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><addtitle>Sleep</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>37</volume><issue>6</issue><spage>1103</spage><epage>1110</epage><pages>1103-1110</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract>Evaluate the relative contributions of weight status and obstructive sleep apnea (OSA) to cardiopulmonary exercise responses in children.
Prospective, cross-sectional study. Participants underwent anthropometric measurements, overnight polysomnography, spirometry, cardiopulmonary exercise function testing on a cycle ergometer, and cardiac doppler imaging. OSA was defined as ≥ 1 obstructive apnea or hypopnea per hour of sleep (OAHI). The effect of OSA on exercise function was evaluated after the parameters were corrected for body mass index (BMI) z-scores. Similarly, the effect of obesity on exercise function was examined when the variables were adjusted for OAHI.
Tertiary pediatric hospital.
Healthy weight and obese children, aged 7-12 y.
N/A.
Seventy-one children were studied. In comparison with weight-matched children without OSA, children with OSA had a lower cardiac output, stroke volume index, heart rate, and oxygen consumption (VO2 peak) at peak exercise capacity. After adjusting for BMI z-score, children with OSA had 1.5 L/min (95% confidence interval -2.3 to -0.6 L/min; P = 0.001) lower cardiac output at peak exercise capacity, but minute ventilation and ventilatory responses to exercise were not affected. Obesity was only associated with physical deconditioning. Cardiac dysfunction was associated with the frequency of respiratory-related arousals, the severity of hypoxia, and heart rate during sleep.
Children with OSA are exercise limited due to a reduced cardiac output and VO2 peak at peak exercise capacity, independent of their weight status. Comorbid OSA can further decrease exercise performance in obese children.</abstract><cop>United States</cop><pub>Associated Professional Sleep Societies, LLC</pub><pmid>24882905</pmid><doi>10.5665/sleep.3770</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0161-8105 |
ispartof | Sleep (New York, N.Y.), 2014-06, Vol.37 (6), p.1103-1110 |
issn | 0161-8105 1550-9109 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4015384 |
source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
subjects | Body Mass Index Body Weight Cardiac Output Child Cross-Sectional Studies Effects of OSA and Obesity on Exercise Function in Children Exercise - physiology Exercise Test Female Heart Rate - physiology Humans Male Obesity - complications Obesity - physiopathology Polysomnography Prospective Studies Sleep - physiology Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - physiopathology Spirometry |
title | Effects of obstructive sleep apnea and obesity on exercise function in children |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T14%3A44%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20obstructive%20sleep%20apnea%20and%20obesity%20on%20exercise%20function%20in%20children&rft.jtitle=Sleep%20(New%20York,%20N.Y.)&rft.au=Evans,%20Carla%20A&rft.date=2014-06-01&rft.volume=37&rft.issue=6&rft.spage=1103&rft.epage=1110&rft.pages=1103-1110&rft.issn=0161-8105&rft.eissn=1550-9109&rft_id=info:doi/10.5665/sleep.3770&rft_dat=%3Cproquest_pubme%3E1531953458%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1531953458&rft_id=info:pmid/24882905&rfr_iscdi=true |