Tongue fat infiltration in obese versus lean Zucker rats
Obesity is the most important risk factor for obstructive sleep apnea (OSA), and the effects of obesity may be mediated by tongue fat. Our objective was to examine the effects of obesity on upper airway structures in obese (OBZ) and non-obese (NBZ) Zucker rats. Animal study. Academic Medical Center....
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| Veröffentlicht in: | Sleep (New York, N.Y.) N.Y.), 2014-06, Vol.37 (6), p.1095-1102 |
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| creator | Brennick, Michael J Delikatny, James Pack, Allan I Pickup, Stephen Shinde, Sarika Zhu, Jing-Xu Roscoe, Ivana Kim, David Y Buxbaum, Laurence U Cater, Jacqueline R Schwab, Richard J |
| description | Obesity is the most important risk factor for obstructive sleep apnea (OSA), and the effects of obesity may be mediated by tongue fat. Our objective was to examine the effects of obesity on upper airway structures in obese (OBZ) and non-obese (NBZ) Zucker rats.
Animal study.
Academic Medical Center.
OBZ (638.2 ± 39 g; 14.9 ± 1.1 w) and age-matched NBZ Zucker (442.6 ± 37 g, 15.1 ± 1.5 w) rats.
TONGUE FAT AND VOLUME AND WERE ASSESSED USING: in vivo magnetic resonance spectroscopy (MRS), magnetic resonance imaging including Dixon imaging for tongue fat volume, ex vivo biochemistry (fat quantification; triglyceride (mg)/tissue (g), and histology (Oil Red O stain).
MRS: overall OBZ tongue fat/water ratio was 2.9 times greater than NBZ (P < 0.002) with the anterior OBZ tongue up to 3.3 times greater than NBZ (P < 0.002). Biochemistry: Triglyceride (TG) in the tongue was 4.4 times greater in OBZ versus NBZ (P < 0.0006). TG was greater in OBZ tongue (3.57 ± 1.7 mg/g) than OBZ masseter muscle (0.28 ± 0.1; P < 0.0001) but tongue and masseter TG were not different in NBZ rats (0.82 ± 0.3 versus 0.28 ± 0.1 mg/g, P = 0.67). Dixon fat volume was significantly increased in OBZ (56 ± 15 mm3) versus NBZ (34 ± 5 mm3, P < 0.004). Histology demonstrated a greater degree of intracellular muscle fat and extramuscular fat infiltration in OBZ versus NBZ rats.
Genetically obese rats had a large degree of fat infiltration in the tongue compared to both skeletal muscle and tongue tissues of the non-obese age-matched littermates. The significant fat increase and sequestration in the obese tongue may play a role in altered tongue neuromuscular function, tongue stiffness or metabolic function. |
| doi_str_mv | 10.5665/sleep.3768 |
| format | Article |
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Animal study.
Academic Medical Center.
OBZ (638.2 ± 39 g; 14.9 ± 1.1 w) and age-matched NBZ Zucker (442.6 ± 37 g, 15.1 ± 1.5 w) rats.
TONGUE FAT AND VOLUME AND WERE ASSESSED USING: in vivo magnetic resonance spectroscopy (MRS), magnetic resonance imaging including Dixon imaging for tongue fat volume, ex vivo biochemistry (fat quantification; triglyceride (mg)/tissue (g), and histology (Oil Red O stain).
MRS: overall OBZ tongue fat/water ratio was 2.9 times greater than NBZ (P < 0.002) with the anterior OBZ tongue up to 3.3 times greater than NBZ (P < 0.002). Biochemistry: Triglyceride (TG) in the tongue was 4.4 times greater in OBZ versus NBZ (P < 0.0006). TG was greater in OBZ tongue (3.57 ± 1.7 mg/g) than OBZ masseter muscle (0.28 ± 0.1; P < 0.0001) but tongue and masseter TG were not different in NBZ rats (0.82 ± 0.3 versus 0.28 ± 0.1 mg/g, P = 0.67). Dixon fat volume was significantly increased in OBZ (56 ± 15 mm3) versus NBZ (34 ± 5 mm3, P < 0.004). Histology demonstrated a greater degree of intracellular muscle fat and extramuscular fat infiltration in OBZ versus NBZ rats.
Genetically obese rats had a large degree of fat infiltration in the tongue compared to both skeletal muscle and tongue tissues of the non-obese age-matched littermates. The significant fat increase and sequestration in the obese tongue may play a role in altered tongue neuromuscular function, tongue stiffness or metabolic function.</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.5665/sleep.3768</identifier><identifier>PMID: 24882904</identifier><language>eng</language><publisher>United States: Associated Professional Sleep Societies, LLC</publisher><subject>Adipose Tissue - physiopathology ; Adiposity ; Animals ; Case-Control Studies ; Lipids - analysis ; Male ; Masseter Muscle - anatomy & histology ; Masseter Muscle - physiology ; Obesity - complications ; Obesity - physiopathology ; Rats ; Rats, Zucker ; Respiratory System - physiopathology ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - physiopathology ; Thinness ; Tongue - anatomy & histology ; Tongue - chemistry ; Tongue - physiopathology ; Tongue Fat Infiltration in Obese Versus Lean Zucker Rats ; Water - analysis</subject><ispartof>Sleep (New York, N.Y.), 2014-06, Vol.37 (6), p.1095-1102</ispartof><rights>2014 Associated Professional Sleep Societies, LLC. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-32a6f7af2f5693b58c6b3685e9df0be23858893d68ad4b29497ea14976ae2c4d3</citedby><cites>FETCH-LOGICAL-c444t-32a6f7af2f5693b58c6b3685e9df0be23858893d68ad4b29497ea14976ae2c4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24882904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brennick, Michael J</creatorcontrib><creatorcontrib>Delikatny, James</creatorcontrib><creatorcontrib>Pack, Allan I</creatorcontrib><creatorcontrib>Pickup, Stephen</creatorcontrib><creatorcontrib>Shinde, Sarika</creatorcontrib><creatorcontrib>Zhu, Jing-Xu</creatorcontrib><creatorcontrib>Roscoe, Ivana</creatorcontrib><creatorcontrib>Kim, David Y</creatorcontrib><creatorcontrib>Buxbaum, Laurence U</creatorcontrib><creatorcontrib>Cater, Jacqueline R</creatorcontrib><creatorcontrib>Schwab, Richard J</creatorcontrib><title>Tongue fat infiltration in obese versus lean Zucker rats</title><title>Sleep (New York, N.Y.)</title><addtitle>Sleep</addtitle><description>Obesity is the most important risk factor for obstructive sleep apnea (OSA), and the effects of obesity may be mediated by tongue fat. Our objective was to examine the effects of obesity on upper airway structures in obese (OBZ) and non-obese (NBZ) Zucker rats.
Animal study.
Academic Medical Center.
OBZ (638.2 ± 39 g; 14.9 ± 1.1 w) and age-matched NBZ Zucker (442.6 ± 37 g, 15.1 ± 1.5 w) rats.
TONGUE FAT AND VOLUME AND WERE ASSESSED USING: in vivo magnetic resonance spectroscopy (MRS), magnetic resonance imaging including Dixon imaging for tongue fat volume, ex vivo biochemistry (fat quantification; triglyceride (mg)/tissue (g), and histology (Oil Red O stain).
MRS: overall OBZ tongue fat/water ratio was 2.9 times greater than NBZ (P < 0.002) with the anterior OBZ tongue up to 3.3 times greater than NBZ (P < 0.002). Biochemistry: Triglyceride (TG) in the tongue was 4.4 times greater in OBZ versus NBZ (P < 0.0006). TG was greater in OBZ tongue (3.57 ± 1.7 mg/g) than OBZ masseter muscle (0.28 ± 0.1; P < 0.0001) but tongue and masseter TG were not different in NBZ rats (0.82 ± 0.3 versus 0.28 ± 0.1 mg/g, P = 0.67). Dixon fat volume was significantly increased in OBZ (56 ± 15 mm3) versus NBZ (34 ± 5 mm3, P < 0.004). Histology demonstrated a greater degree of intracellular muscle fat and extramuscular fat infiltration in OBZ versus NBZ rats.
Genetically obese rats had a large degree of fat infiltration in the tongue compared to both skeletal muscle and tongue tissues of the non-obese age-matched littermates. The significant fat increase and sequestration in the obese tongue may play a role in altered tongue neuromuscular function, tongue stiffness or metabolic function.</description><subject>Adipose Tissue - physiopathology</subject><subject>Adiposity</subject><subject>Animals</subject><subject>Case-Control Studies</subject><subject>Lipids - analysis</subject><subject>Male</subject><subject>Masseter Muscle - anatomy & histology</subject><subject>Masseter Muscle - physiology</subject><subject>Obesity - complications</subject><subject>Obesity - physiopathology</subject><subject>Rats</subject><subject>Rats, Zucker</subject><subject>Respiratory System - physiopathology</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - physiopathology</subject><subject>Thinness</subject><subject>Tongue - anatomy & histology</subject><subject>Tongue - chemistry</subject><subject>Tongue - physiopathology</subject><subject>Tongue Fat Infiltration in Obese Versus Lean Zucker Rats</subject><subject>Water - analysis</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1LAzEQhoMotlYv_gDZowhbk81Hk4sgxS8oeKkXLyG7O6mr26QmuwX_vamtRQ8zw8s8vDO8CJ0TPOZC8OvYAqzGdCLkARoSznGuCFaHaIiJILkkmA_QSYzvOGmm6DEaFEzKQmE2RHLu3aKHzJoua5xt2i6YrvEuicyXECFbQ4h9zFowLnvtqw8IWULiKTqypo1wtpsj9HJ_N58-5rPnh6fp7SyvGGNdTgsj7MTYwnKhaMllJUoqJAdVW1xCQSWXUtFaSFOzslBMTcCQ1IWBomI1HaGbre-qL5dQV-DSh61ehWZpwpf2ptH_N6550wu_1gwTTiVNBpc7g-A_e4idXjaxgrY1DnwfdaKISoVZQq-2aBV8jAHs_gzBehO1_olab6JO8MXfx_bob7b0G9Fueys</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Brennick, Michael J</creator><creator>Delikatny, James</creator><creator>Pack, Allan I</creator><creator>Pickup, Stephen</creator><creator>Shinde, Sarika</creator><creator>Zhu, Jing-Xu</creator><creator>Roscoe, Ivana</creator><creator>Kim, David Y</creator><creator>Buxbaum, Laurence U</creator><creator>Cater, Jacqueline R</creator><creator>Schwab, Richard J</creator><general>Associated Professional Sleep Societies, LLC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140601</creationdate><title>Tongue fat infiltration in obese versus lean Zucker rats</title><author>Brennick, Michael J ; Delikatny, James ; Pack, Allan I ; Pickup, Stephen ; Shinde, Sarika ; Zhu, Jing-Xu ; Roscoe, Ivana ; Kim, David Y ; Buxbaum, Laurence U ; Cater, Jacqueline R ; Schwab, Richard J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-32a6f7af2f5693b58c6b3685e9df0be23858893d68ad4b29497ea14976ae2c4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adipose Tissue - physiopathology</topic><topic>Adiposity</topic><topic>Animals</topic><topic>Case-Control Studies</topic><topic>Lipids - analysis</topic><topic>Male</topic><topic>Masseter Muscle - anatomy & histology</topic><topic>Masseter Muscle - physiology</topic><topic>Obesity - complications</topic><topic>Obesity - physiopathology</topic><topic>Rats</topic><topic>Rats, Zucker</topic><topic>Respiratory System - physiopathology</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - physiopathology</topic><topic>Thinness</topic><topic>Tongue - anatomy & histology</topic><topic>Tongue - chemistry</topic><topic>Tongue - physiopathology</topic><topic>Tongue Fat Infiltration in Obese Versus Lean Zucker Rats</topic><topic>Water - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brennick, Michael J</creatorcontrib><creatorcontrib>Delikatny, James</creatorcontrib><creatorcontrib>Pack, Allan I</creatorcontrib><creatorcontrib>Pickup, Stephen</creatorcontrib><creatorcontrib>Shinde, Sarika</creatorcontrib><creatorcontrib>Zhu, Jing-Xu</creatorcontrib><creatorcontrib>Roscoe, Ivana</creatorcontrib><creatorcontrib>Kim, David Y</creatorcontrib><creatorcontrib>Buxbaum, Laurence U</creatorcontrib><creatorcontrib>Cater, Jacqueline R</creatorcontrib><creatorcontrib>Schwab, Richard J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brennick, Michael J</au><au>Delikatny, James</au><au>Pack, Allan I</au><au>Pickup, Stephen</au><au>Shinde, Sarika</au><au>Zhu, Jing-Xu</au><au>Roscoe, Ivana</au><au>Kim, David Y</au><au>Buxbaum, Laurence U</au><au>Cater, Jacqueline R</au><au>Schwab, Richard J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tongue fat infiltration in obese versus lean Zucker rats</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><addtitle>Sleep</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>37</volume><issue>6</issue><spage>1095</spage><epage>1102</epage><pages>1095-1102</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract>Obesity is the most important risk factor for obstructive sleep apnea (OSA), and the effects of obesity may be mediated by tongue fat. Our objective was to examine the effects of obesity on upper airway structures in obese (OBZ) and non-obese (NBZ) Zucker rats.
Animal study.
Academic Medical Center.
OBZ (638.2 ± 39 g; 14.9 ± 1.1 w) and age-matched NBZ Zucker (442.6 ± 37 g, 15.1 ± 1.5 w) rats.
TONGUE FAT AND VOLUME AND WERE ASSESSED USING: in vivo magnetic resonance spectroscopy (MRS), magnetic resonance imaging including Dixon imaging for tongue fat volume, ex vivo biochemistry (fat quantification; triglyceride (mg)/tissue (g), and histology (Oil Red O stain).
MRS: overall OBZ tongue fat/water ratio was 2.9 times greater than NBZ (P < 0.002) with the anterior OBZ tongue up to 3.3 times greater than NBZ (P < 0.002). Biochemistry: Triglyceride (TG) in the tongue was 4.4 times greater in OBZ versus NBZ (P < 0.0006). TG was greater in OBZ tongue (3.57 ± 1.7 mg/g) than OBZ masseter muscle (0.28 ± 0.1; P < 0.0001) but tongue and masseter TG were not different in NBZ rats (0.82 ± 0.3 versus 0.28 ± 0.1 mg/g, P = 0.67). Dixon fat volume was significantly increased in OBZ (56 ± 15 mm3) versus NBZ (34 ± 5 mm3, P < 0.004). Histology demonstrated a greater degree of intracellular muscle fat and extramuscular fat infiltration in OBZ versus NBZ rats.
Genetically obese rats had a large degree of fat infiltration in the tongue compared to both skeletal muscle and tongue tissues of the non-obese age-matched littermates. The significant fat increase and sequestration in the obese tongue may play a role in altered tongue neuromuscular function, tongue stiffness or metabolic function.</abstract><cop>United States</cop><pub>Associated Professional Sleep Societies, LLC</pub><pmid>24882904</pmid><doi>10.5665/sleep.3768</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adipose Tissue - physiopathology Adiposity Animals Case-Control Studies Lipids - analysis Male Masseter Muscle - anatomy & histology Masseter Muscle - physiology Obesity - complications Obesity - physiopathology Rats Rats, Zucker Respiratory System - physiopathology Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - physiopathology Thinness Tongue - anatomy & histology Tongue - chemistry Tongue - physiopathology Tongue Fat Infiltration in Obese Versus Lean Zucker Rats Water - analysis |
| title | Tongue fat infiltration in obese versus lean Zucker rats |
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