Quantitative Phosphoproteomics Unravels Biased Phosphorylation of Serotonin 2A Receptor at Ser280 by Hallucinogenic versus Nonhallucinogenic Agonists

The serotonin 5-HT2A receptor is a primary target of psychedelic hallucinogens such as lysergic acid diethylamine, mescaline, and psilocybin, which reproduce some of the core symptoms of schizophrenia. An incompletely resolved paradox is that only some 5-HT2A receptor agonists exhibit hallucinogenic...

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Veröffentlicht in:	Molecular & cellular proteomics 2014-05, Vol.13 (5), p.1273-1285
Hauptverfasser:	Karaki, Samah, Becamel, Carine, Murat, Samy, Mannoury la Cour, Clotilde, Millan, Mark J., Prézeau, Laurent, Bockaert, Joël, Marin, Philippe, Vandermoere, Franck
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamines - pharmacology Animals Cells, Cultured Gene Expression Regulation - drug effects Hallucinogens - pharmacology HEK293 Cells Humans Lisuride - pharmacology Mice Neurons - metabolism Phosphorylation Prefrontal Cortex - metabolism Proteomics - methods Receptor, Serotonin, 5-HT2A - metabolism Serine - metabolism Serotonin 5-HT2 Receptor Agonists - pharmacology Signal Transduction - drug effects
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