The prevalence and prevention of nasopharyngeal carcinoma in China
Nasopharyngeal carcinoma （NPC） has remarkable epidemiological features, including regional, racial, and familial aggregations. The aim of this review is to describe the epidemiological characteristics of NPC and to propose possible causes for the high incidence patterns in southern China. Since the...
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| Veröffentlicht in: | Ai zheng 2011-02, Vol.30 (2), p.114-119 |
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| description | Nasopharyngeal carcinoma （NPC） has remarkable epidemiological features, including regional, racial, and familial aggregations. The aim of this review is to describe the epidemiological characteristics of NPC and to propose possible causes for the high incidence patterns in southern China. Since the etiology of NPC is not completely understood, approaches to primary prevention of NPC remain under consideration. This situation highlights the need to conduct secondary prevention, including improving rates of early detection, early diagnosis, and early treatment in NPC patients. Since the 1970＇s, high-risk populations in southern China have been screened extensively for early detection of NPC using anti-Epstein-Barr virus （EBV） serum biomarkers. This review summarizes several large screening studies that have been conducted in the high-incidence areas of China. Screening markers, high-risk age range for screening, time intervals for blood re-examination, and the effectiveness of these screening studies will be discussed. Conduction of prospective randomized controlled screening trials in southern China can be expected to maximize the cost-effectiveness of early NPC detection screening. |
| doi_str_mv | 10.5732/cjc.010.10377 |
| format | Article |
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The aim of this review is to describe the epidemiological characteristics of NPC and to propose possible causes for the high incidence patterns in southern China. Since the etiology of NPC is not completely understood, approaches to primary prevention of NPC remain under consideration. This situation highlights the need to conduct secondary prevention, including improving rates of early detection, early diagnosis, and early treatment in NPC patients. Since the 1970＇s, high-risk populations in southern China have been screened extensively for early detection of NPC using anti-Epstein-Barr virus （EBV） serum biomarkers. This review summarizes several large screening studies that have been conducted in the high-incidence areas of China. Screening markers, high-risk age range for screening, time intervals for blood re-examination, and the effectiveness of these screening studies will be discussed. 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All Rights Reserved.</rights><rights>Chinese Journal of Cancer 2011</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/90720X/90720X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013340/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013340/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21272443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cao, Su-Mei</creatorcontrib><creatorcontrib>Simons, Malcolm J</creatorcontrib><creatorcontrib>Qian, Chao-Nan</creatorcontrib><title>The prevalence and prevention of nasopharyngeal carcinoma in China</title><title>Ai zheng</title><addtitle>Chinese Journal of Cancer</addtitle><description>Nasopharyngeal carcinoma （NPC） has remarkable epidemiological features, including regional, racial, and familial aggregations. The aim of this review is to describe the epidemiological characteristics of NPC and to propose possible causes for the high incidence patterns in southern China. Since the etiology of NPC is not completely understood, approaches to primary prevention of NPC remain under consideration. This situation highlights the need to conduct secondary prevention, including improving rates of early detection, early diagnosis, and early treatment in NPC patients. Since the 1970＇s, high-risk populations in southern China have been screened extensively for early detection of NPC using anti-Epstein-Barr virus （EBV） serum biomarkers. This review summarizes several large screening studies that have been conducted in the high-incidence areas of China. Screening markers, high-risk age range for screening, time intervals for blood re-examination, and the effectiveness of these screening studies will be discussed. Conduction of prospective randomized controlled screening trials in southern China can be expected to maximize the cost-effectiveness of early NPC detection screening.</description><subject>Age Factors</subject><subject>Antibodies, Viral - analysis</subject><subject>Antigens, Viral - analysis</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Capsid Proteins - analysis</subject><subject>Carcinoma</subject><subject>China - epidemiology</subject><subject>Early Detection of Cancer - methods</subject><subject>Herpesvirus 4, Human - immunology</subject><subject>Humans</subject><subject>Nasopharyngeal Carcinoma</subject><subject>Nasopharyngeal Neoplasms - epidemiology</subject><subject>Nasopharyngeal Neoplasms - genetics</subject><subject>Nasopharyngeal Neoplasms - immunology</subject><subject>Nasopharyngeal Neoplasms - prevention & control</subject><subject>Prevalence</subject><subject>中国南部</subject><subject>全国人民代表大会</subject><subject>早期治疗</subject><subject>流行病学特点</subject><subject>筛选标记</subject><subject>随机对照试验</subject><subject>预防</subject><subject>鼻咽癌</subject><issn>1000-467X</issn><issn>1944-446X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM1LAzEQxYMottQevcqi5635zvYiaPELCl566C3MZpPd1G1Sd21F_3qDVdHTzGMev_cYhE4JngjF6KVZmQlOgmCm1AEakinnOedyeZh2jHHOpVoO0LjvfYmJkrRQQh6jASVUUc7ZEN0sGpttOruD1gZjMwjVl7Th1ceQRZcF6OOmge491BbazEBnfIhryHzIZo0PcIKOHLS9HX_PEVrc3S5mD_n86f5xdj3PDWFM5ExSa6AAzpVkhVBuWlgwTAjMKZZQSsqNK40UU2mgLApBDKuqwkrHsGWOjdDVHrvZlmtbmdSwg1ZvOr9O5XQEr_9fgm90HXea45TPcQJc7AFvEByEWq_itgupsbYfFBOCKcYiuc7-xvzyf16WDOd7g2liqF98ApVgnp1vrWZKMMWIYJ_rRnpa</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Cao, Su-Mei</creator><creator>Simons, Malcolm J</creator><creator>Qian, Chao-Nan</creator><general>State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China</general><general>Simons Haplomics Limited, Hong Kong SAR, P. R. China%State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China</general><general>Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China</general><general>Laboratory of Genome Biology, Van Andel Research Institute, 333 Bostwick Ave NE, Grand Rapids, Michigan 49503, USA</general><general>Department of Epidemiology, Clinical Trial Study Center, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China%Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, Guandong 510060, P. R. 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The aim of this review is to describe the epidemiological characteristics of NPC and to propose possible causes for the high incidence patterns in southern China. Since the etiology of NPC is not completely understood, approaches to primary prevention of NPC remain under consideration. This situation highlights the need to conduct secondary prevention, including improving rates of early detection, early diagnosis, and early treatment in NPC patients. Since the 1970＇s, high-risk populations in southern China have been screened extensively for early detection of NPC using anti-Epstein-Barr virus （EBV） serum biomarkers. This review summarizes several large screening studies that have been conducted in the high-incidence areas of China. Screening markers, high-risk age range for screening, time intervals for blood re-examination, and the effectiveness of these screening studies will be discussed. Conduction of prospective randomized controlled screening trials in southern China can be expected to maximize the cost-effectiveness of early NPC detection screening.</abstract><cop>England</cop><pub>State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China</pub><pmid>21272443</pmid><doi>10.5732/cjc.010.10377</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Age Factors Antibodies, Viral - analysis Antigens, Viral - analysis Asian Continental Ancestry Group - genetics Capsid Proteins - analysis Carcinoma China - epidemiology Early Detection of Cancer - methods Herpesvirus 4, Human - immunology Humans Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms - epidemiology Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - immunology Nasopharyngeal Neoplasms - prevention & control Prevalence 中国南部 全国人民代表大会 早期治疗 流行病学特点 筛选标记 随机对照试验 预防 鼻咽癌 |
| title | The prevalence and prevention of nasopharyngeal carcinoma in China |
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