Memory NK cells： why do they reside in the liver
Immune memory is the hallmark of adaptive immunity. However, recent studies have shown that natural killer （NK） cells, key components of the innate immune system, also mediate memory responses in mice and humans. Strikingly, memory NK cells were liver-resident in some models, raising the question as...
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| Veröffentlicht in: | Cellular & molecular immunology 2013-05, Vol.10 (3), p.196-201 |
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| creator | Jiang, Xiaojun Chen, Yonglin Peng, Hui Tian, Zhigang |
| description | Immune memory is the hallmark of adaptive immunity. However, recent studies have shown that natural killer （NK） cells, key components of the innate immune system, also mediate memory responses in mice and humans. Strikingly, memory NK cells were liver-resident in some models, raising the question as to whether the liver is a special organ for the acquisition of NK cell memory. Here, we review the characteristics of N K cell memory by summarizing recent progress and discuss how the liver may generate both the initiation and the recall phase of memory. We propose that the liver may have unique precursors for memory NK cells, which are developmentally distinct from NK cells derived from bone marrow. |
| doi_str_mv | 10.1038/cmi.2013.8 |
| format | Article |
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However, recent studies have shown that natural killer （NK） cells, key components of the innate immune system, also mediate memory responses in mice and humans. Strikingly, memory NK cells were liver-resident in some models, raising the question as to whether the liver is a special organ for the acquisition of NK cell memory. Here, we review the characteristics of N K cell memory by summarizing recent progress and discuss how the liver may generate both the initiation and the recall phase of memory. We propose that the liver may have unique precursors for memory NK cells, which are developmentally distinct from NK cells derived from bone marrow.</description><identifier>ISSN: 1672-7681</identifier><identifier>EISSN: 2042-0226</identifier><identifier>DOI: 10.1038/cmi.2013.8</identifier><identifier>PMID: 23563088</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adaptive immunity ; Animals ; Antibodies ; Antigens - immunology ; Biomedical and Life Sciences ; Biomedicine ; Bone marrow ; Hepatocytes ; Humans ; Immune system ; Immunologic Memory - immunology ; Immunological memory ; Immunology ; Innate immunity ; Killer Cells, Natural - cytology ; Killer Cells, Natural - immunology ; Liver ; Liver - cytology ; Liver - immunology ; Medical Microbiology ; Microbiology ; Models, Immunological ; Natural killer cells ; NK细胞 ; Review ; Vaccine ; 免疫系统 ; 免疫记忆 ; 居住 ; 组成部分 ; 细胞来源 ; 肝脏 ; 适应性</subject><ispartof>Cellular & molecular immunology, 2013-05, Vol.10 (3), p.196-201</ispartof><rights>Chinese Society of Immunology and The University of Science and Technology 2013</rights><rights>Copyright Nature Publishing Group May 2013</rights><rights>Chinese Society of Immunology and The University of Science and Technology 2013.</rights><rights>Copyright © 2013 Chinese Society of Immunology and The University of Science and Technology 2013 Chinese Society of Immunology and The University of Science and Technology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-b03f39d8fd83f44a37bd8983fc55e3eb3155c5715e333158f8dfd6166691d6633</citedby><cites>FETCH-LOGICAL-c529t-b03f39d8fd83f44a37bd8983fc55e3eb3155c5715e333158f8dfd6166691d6633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/87787X/87787X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012773/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012773/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23563088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Xiaojun</creatorcontrib><creatorcontrib>Chen, Yonglin</creatorcontrib><creatorcontrib>Peng, Hui</creatorcontrib><creatorcontrib>Tian, Zhigang</creatorcontrib><title>Memory NK cells： why do they reside in the liver</title><title>Cellular & molecular immunology</title><addtitle>Cell Mol Immunol</addtitle><addtitle>Cellular ＆ Molecular Immunology</addtitle><description>Immune memory is the hallmark of adaptive immunity. However, recent studies have shown that natural killer （NK） cells, key components of the innate immune system, also mediate memory responses in mice and humans. Strikingly, memory NK cells were liver-resident in some models, raising the question as to whether the liver is a special organ for the acquisition of NK cell memory. Here, we review the characteristics of N K cell memory by summarizing recent progress and discuss how the liver may generate both the initiation and the recall phase of memory. We propose that the liver may have unique precursors for memory NK cells, which are developmentally distinct from NK cells derived from bone marrow.</description><subject>Adaptive immunity</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antigens - immunology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bone marrow</subject><subject>Hepatocytes</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunologic Memory - immunology</subject><subject>Immunological memory</subject><subject>Immunology</subject><subject>Innate immunity</subject><subject>Killer Cells, Natural - cytology</subject><subject>Killer Cells, Natural - immunology</subject><subject>Liver</subject><subject>Liver - cytology</subject><subject>Liver - immunology</subject><subject>Medical Microbiology</subject><subject>Microbiology</subject><subject>Models, Immunological</subject><subject>Natural killer cells</subject><subject>NK细胞</subject><subject>Review</subject><subject>Vaccine</subject><subject>免疫系统</subject><subject>免疫记忆</subject><subject>居住</subject><subject>组成部分</subject><subject>细胞来源</subject><subject>肝脏</subject><subject>适应性</subject><issn>1672-7681</issn><issn>2042-0226</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUtu2zAQhomgQeM8NjlAoSKbIIFcksOXNgGCII8ibrtp1oQsUrYCSYxJ24GukrPkTr1CKdgx3CJoV5zBfPwIzo_QMcFDgkF9KZpqSDGBodpBA4oZTTGl4gMaECFpKoUie2g_hEeMuWKSfUR7FLgArNQA0W-2cb5Lvt8nha3r8Ov1JXmedolxyXxqu8TbUBmbVG3fJnW1tP4Q7ZZ5HezR-jxADzfXP6_u0tGP269Xl6O04DSbp2MMJWRGlUZByVgOcmxUFuuCcwt2DITzgksSG4i1KpUpjSBCiIwYIQAO0MXK-7QYN9YUtp37vNZPvmpy32mXV_rPSVtN9cQtNcOEStkLTtcC72YLG-a6qUL_y7y1bhE0YcAwsIyq_6MRwxkVqree_IU-uoVv4yY0lSLmwQRW_6KIVJwTgpmI1NmKKrwLwdty8zuCdZ-tjtnqPlvdKz9t72ODvoUZgfMVEOKonVi_9eZ7us_rt6eunczihY2RCUK5BAa_AdyTtog</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Jiang, Xiaojun</creator><creator>Chen, Yonglin</creator><creator>Peng, Hui</creator><creator>Tian, Zhigang</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20130501</creationdate><title>Memory NK cells： why do they reside in the liver</title><author>Jiang, Xiaojun ; Chen, Yonglin ; Peng, Hui ; Tian, Zhigang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-b03f39d8fd83f44a37bd8983fc55e3eb3155c5715e333158f8dfd6166691d6633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adaptive immunity</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antigens - immunology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bone marrow</topic><topic>Hepatocytes</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunologic Memory - immunology</topic><topic>Immunological memory</topic><topic>Immunology</topic><topic>Innate immunity</topic><topic>Killer Cells, Natural - cytology</topic><topic>Killer Cells, Natural - immunology</topic><topic>Liver</topic><topic>Liver - cytology</topic><topic>Liver - immunology</topic><topic>Medical Microbiology</topic><topic>Microbiology</topic><topic>Models, Immunological</topic><topic>Natural killer cells</topic><topic>NK细胞</topic><topic>Review</topic><topic>Vaccine</topic><topic>免疫系统</topic><topic>免疫记忆</topic><topic>居住</topic><topic>组成部分</topic><topic>细胞来源</topic><topic>肝脏</topic><topic>适应性</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Xiaojun</creatorcontrib><creatorcontrib>Chen, Yonglin</creatorcontrib><creatorcontrib>Peng, Hui</creatorcontrib><creatorcontrib>Tian, Zhigang</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular & molecular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Xiaojun</au><au>Chen, Yonglin</au><au>Peng, Hui</au><au>Tian, Zhigang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Memory NK cells： why do they reside in the liver</atitle><jtitle>Cellular & molecular immunology</jtitle><stitle>Cell Mol Immunol</stitle><addtitle>Cellular ＆ Molecular Immunology</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>10</volume><issue>3</issue><spage>196</spage><epage>201</epage><pages>196-201</pages><issn>1672-7681</issn><eissn>2042-0226</eissn><abstract>Immune memory is the hallmark of adaptive immunity. However, recent studies have shown that natural killer （NK） cells, key components of the innate immune system, also mediate memory responses in mice and humans. Strikingly, memory NK cells were liver-resident in some models, raising the question as to whether the liver is a special organ for the acquisition of NK cell memory. Here, we review the characteristics of N K cell memory by summarizing recent progress and discuss how the liver may generate both the initiation and the recall phase of memory. We propose that the liver may have unique precursors for memory NK cells, which are developmentally distinct from NK cells derived from bone marrow.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23563088</pmid><doi>10.1038/cmi.2013.8</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adaptive immunity Animals Antibodies Antigens - immunology Biomedical and Life Sciences Biomedicine Bone marrow Hepatocytes Humans Immune system Immunologic Memory - immunology Immunological memory Immunology Innate immunity Killer Cells, Natural - cytology Killer Cells, Natural - immunology Liver Liver - cytology Liver - immunology Medical Microbiology Microbiology Models, Immunological Natural killer cells NK细胞 Review Vaccine 免疫系统 免疫记忆 居住 组成部分 细胞来源 肝脏 适应性 |
| title | Memory NK cells： why do they reside in the liver |
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