Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents

Chronic stress is generally known to exacerbate the development of numerous neuropsychiatric diseases such as fear and anxiety disorders, which is at least partially due to the disinhibition of amygdala subsequent to the prolonged stress exposure. GABA receptor A (GABAAR) mediates the primary compon...

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Veröffentlicht in:	Molecular brain 2014-04, Vol.7 (1), p.32-32, Article 32
Hauptverfasser:	Liu, Zhi-Peng, Song, Chen, Wang, Min, He, Ye, Xu, Xiao-Bin, Pan, Han-Qing, Chen, Wen-Bing, Peng, Wei-Jie, Pan, Bing-Xing
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Amygdala - drug effects Amygdala - metabolism Amygdala - physiopathology Animals Anxiety Chronic Disease Complications and side effects Corticosterone Corticosterone - biosynthesis Development and progression Experiments GABA gamma-Aminobutyric Acid - pharmacology Immobilization Inhibition (Psychology) Inhibitory Postsynaptic Potentials - drug effects Ion Channel Gating - drug effects Male Mice Mice, Inbred C57BL Neurons Neurons - drug effects Neurons - metabolism Neurons - pathology Physiological aspects Receptors, GABA-A - metabolism Receptors, Glucocorticoid - metabolism Risk factors Rodents Stress Stress (Psychology) Stress, Psychological - pathology Stress, Psychological - physiopathology Studies Tetanus
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