Mitochondrial damage-associated molecular patterns and vascular function
Immune system activation occurs not only due to foreign stimuli, but also due to endogenous molecules. As such, endogenous molecules that are released into the circulation due to cell death and/or injury alarm the immune system that something has disturbed homeostasis and a response is needed. Colle...
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| Veröffentlicht in: | European heart journal 2014-05, Vol.35 (18), p.1172-1177 |
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| container_title | European heart journal |
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| creator | Wenceslau, Camilla Ferreira McCarthy, Cameron G. Szasz, Theodora Spitler, Kathryn Goulopoulou, Styliani Webb, R. Clinton |
| description | Immune system activation occurs not only due to foreign stimuli, but also due to endogenous molecules. As such, endogenous molecules that are released into the circulation due to cell death and/or injury alarm the immune system that something has disturbed homeostasis and a response is needed. Collectively, these molecules are known as damage-associated molecular patterns (DAMPs). Mitochondrial DAMPs (mtDAMPs) are potent immunological activators due to the bacterial ancestry of mitochondria. Mitochondrial DAMPs are recognized by specific pattern recognition receptors of the innate immune system, some of which are expressed in the cardiovascular system. Cell death leads to release of mtDAMPs that may induce vascular changes by mechanisms that are currently not well understood. This review will focus on recently published evidence linking mtDAMPs and immune system activation to vascular dysfunction and cardiovascular disease. |
| doi_str_mv | 10.1093/eurheartj/ehu047 |
| format | Article |
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Cell death leads to release of mtDAMPs that may induce vascular changes by mechanisms that are currently not well understood. This review will focus on recently published evidence linking mtDAMPs and immune system activation to vascular dysfunction and cardiovascular disease.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehu047</identifier><identifier>PMID: 24569027</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Cardiovascular Diseases - immunology ; Cytokines - metabolism ; DNA, Mitochondrial - immunology ; Humans ; Immunity, Innate - immunology ; Mitochondria - immunology ; Mitochondria - physiology ; Mitochondrial Diseases - immunology ; Oligopeptides - metabolism ; REVIEWS</subject><ispartof>European heart journal, 2014-05, Vol.35 (18), p.1172-1177</ispartof><rights>Published on behalf of the European Society of Cardiology. 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Mitochondrial DAMPs are recognized by specific pattern recognition receptors of the innate immune system, some of which are expressed in the cardiovascular system. Cell death leads to release of mtDAMPs that may induce vascular changes by mechanisms that are currently not well understood. This review will focus on recently published evidence linking mtDAMPs and immune system activation to vascular dysfunction and cardiovascular disease.</description><subject>Cardiovascular Diseases - immunology</subject><subject>Cytokines - metabolism</subject><subject>DNA, Mitochondrial - immunology</subject><subject>Humans</subject><subject>Immunity, Innate - immunology</subject><subject>Mitochondria - immunology</subject><subject>Mitochondria - physiology</subject><subject>Mitochondrial Diseases - immunology</subject><subject>Oligopeptides - metabolism</subject><subject>REVIEWS</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9L5TAQx8OirM_n3ve09ChI10maNMlFEPHHguLFg7cwTVJfpW3eJqngf7-V6mM9eRqY-X6_M_Mh5CeF3xR0deqnuPEY8_Op30zA5TeyooKxUtdc7JEVUC3KulaPB-QwpWcAUDWtv5MDxkWtgckVubnrcrCbMLrYYV84HPDJl5hSsB1m74oh9N5OPcZiizn7OKYCR1e8YFq67TTa3IXxiOy32Cf_472uycPV5cPFTXl7f_3n4vy2tFyrXMrGOSeVBNpo7momnJayAWWFVryV3DKBqmFcSkEFBcAKmZ5frdrKKu6qNTlbYrdTM3hn_Zgj9mYbuwHjqwnYmc-TsduYp_BiOFAm56A1OX4PiOHv5FM2Q5es73scfZiSmflVHICrepbCIrUxpBR9u1tDwbzxNzv-ZuE_W379f97O8AF8FpwsgjBtv477B21alXU</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Wenceslau, Camilla Ferreira</creator><creator>McCarthy, Cameron G.</creator><creator>Szasz, Theodora</creator><creator>Spitler, Kathryn</creator><creator>Goulopoulou, Styliani</creator><creator>Webb, R. 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| ispartof | European heart journal, 2014-05, Vol.35 (18), p.1172-1177 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Cardiovascular Diseases - immunology Cytokines - metabolism DNA, Mitochondrial - immunology Humans Immunity, Innate - immunology Mitochondria - immunology Mitochondria - physiology Mitochondrial Diseases - immunology Oligopeptides - metabolism REVIEWS |
| title | Mitochondrial damage-associated molecular patterns and vascular function |
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