Chitinase 3-like 1 synergistically activates IL6-mediated STAT3 phosphorylation in intestinal epithelial cells in murine models of infectious colitis

Chitinase 3-like 1 (CHI3L1) is an inducible molecule on intestinal epithelial cells during the development of inflammatory bowel disease. To investigate the role of CHI3L1 in bacterial infectious colitis, we orally inoculated pathogenic Salmonella typhimurium and potentially pathogenic adherent-inva...

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Veröffentlicht in:	Inflammatory bowel diseases 2014-05, Vol.20 (5), p.835-846
Hauptverfasser:	Tran, Hoa T, Lee, In-Ah, Low, Daren, Kamba, Alan, Mizoguchi, Atsushi, Shi, Hai N, Lee, Chun G, Elias, Jack A, Mizoguchi, Emiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Adhesion Blotting, Western Cells, Cultured Chitinase-3-Like Protein 1 Colitis - metabolism Colitis - microbiology Colitis - pathology Disease Models, Animal Epithelial Cells - metabolism Epithelial Cells - microbiology Epithelial Cells - pathology Escherichia coli Escherichia coli - pathogenicity Escherichia coli Infections - metabolism Escherichia coli Infections - microbiology Escherichia coli Infections - pathology Glycoproteins - physiology Immunoenzyme Techniques Interleukin-6 - metabolism Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Mice Mice, Inbred C57BL Mice, Knockout NF-kappa B - metabolism Phosphorylation Salmonella Infections, Animal - metabolism Salmonella Infections, Animal - microbiology Salmonella Infections, Animal - pathology Salmonella typhimurium Salmonella typhimurium - pathogenicity Signal Transduction STAT3 Transcription Factor - metabolism
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