Crystal structure of the TRIM25 B30.2 (PRYSPRY) domain: a key component of antiviral signalling

TRIM (tripartite motif) proteins primarily function as ubiquitin E3 ligases that regulate the innate immune response to infection. TRIM25 [also known as Efp (oestrogen-responsive finger protein)] has been implicated in the regulation of oestrogen receptor α signalling and in the regulation of innate...

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Veröffentlicht in:	Biochemical journal 2013-12, Vol.456 (2), p.231-240
Hauptverfasser:	D'Cruz, Akshay A, Kershaw, Nadia J, Chiang, Jessica J, Wang, May K, Nicola, Nicos A, Babon, Jeffrey J, Gack, Michaela U, Nicholson, Sandra E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites Conserved Sequence Crystallography, X-Ray DNA-Binding Proteins - chemistry Hydrogen Bonding Immunity, Innate Mice Models, Molecular Molecular Sequence Data Protein Interaction Domains and Motifs Protein Structure, Secondary Structural Homology, Protein Transcription Factors - chemistry Virus Diseases - immunology
Online-Zugang:	Volltext
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