Prediction of Efficacy of Vabicaserin, a 5‐HT2C Agonist, for the Treatment of Schizophrenia Using a Quantitative Systems Pharmacology Model

A quantitative systems pharmacology model that combines in vitro/preclinical neurophysiology data, human imaging data, and patient disease information was used to blindly predict steady‐state clinical efficacy of vabicaserin, a 5‐HT2C full agonist, in monotherapy and, subsequently, to assess adjunct...

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Veröffentlicht in:	CPT: pharmacometrics and systems pharmacology 2014-04, Vol.3 (4), p.1-8
Hauptverfasser:	Liu, J, Ogden, A, Comery, TA, Spiros, A, Roberts, P, Geerts, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Original
Online-Zugang:	Volltext
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