Inhibition of Gαi activity by Gβγ is mediated by PI 3-kinase-γ- and cSrc-dependent tyrosine phosphorylation of Gαi and recruitment of RGS12

Others and we have characterized several Gβγ-dependent effectors in smooth muscle, including G protein-coupled receptor kinase 2 (GRK2), PLCβ3, and phosphatidylinositol (PI) 3-kinase-γ, and have identified various signaling targets downstream of PI 3-kinase-γ, including cSrc, integrin-linked kinase,...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2014-05, Vol.306 (9), p.G802-G810
Hauptverfasser:	Huang, Jiean, Nalli, Ancy D, Mahavadi, Sunila, Kumar, Divya P, Murthy, Karnam S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine A1 Receptor Agonists - pharmacology Analgesics, Opioid - pharmacology Animals Cells, Cultured Cyclic AMP - metabolism Enzyme Activation Feedback, Physiological GTP-Binding Protein alpha Subunit, Gi2 - genetics GTP-Binding Protein alpha Subunit, Gi2 - metabolism GTP-Binding Protein beta Subunits - metabolism GTP-Binding Protein gamma Subunits - metabolism Hormones and Signaling Muscarinic Agonists - pharmacology Muscle Relaxation - drug effects Mutation Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - enzymology Phosphatidylinositol 3-Kinase - antagonists & inhibitors Phosphatidylinositol 3-Kinase - metabolism Phosphorylation Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins pp60(c-src) - antagonists & inhibitors Proto-Oncogene Proteins pp60(c-src) - metabolism Rabbits Receptor, Adenosine A1 - drug effects Receptor, Adenosine A1 - metabolism Receptor, Muscarinic M2 - agonists Receptor, Muscarinic M2 - metabolism Receptors, Opioid, delta - agonists Receptors, Opioid, delta - metabolism Receptors, Somatostatin - agonists Receptors, Somatostatin - metabolism RGS Proteins - genetics RGS Proteins - metabolism RNA Interference Signal Transduction Stomach - cytology Stomach - drug effects Stomach - enzymology Transfection Tyrosine
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