Nerve growth factor induces cord formation of mesenchymal stem cell by promoting proliferation and activating the PI3K/Akt signaling pathway

Aim： To investigate whether nerve growth factor （NGF） induced angiogenesis of bone marrow mesenchymal stem cells （MSCs） and the underlying mechanisms. Methods： Bone marrow MSCs were isolated from femors or tibias of Sprague-Dawley rat, and cultured. The cells were purified after 3 to 5 passages, see...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta pharmacologica Sinica 2011-12, Vol.32 (12), p.1483-1490
Hauptverfasser:	Wang, Wen-xia, Hu, Xin-yang, Xie, Xiao-jie, Liu, Xian-bao, Wu, Rong-rong, Wang, Ya-ping, Gao, Feng, Wang, Jian-an
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Angiogenesis Animals Biomedical and Life Sciences Biomedicine Bone marrow Cell Proliferation Cells, Cultured Enumeration Enzyme Activation Flow Cytometry Gene expression Growth curves Immunology Internal Medicine Male Medical Microbiology Mesenchymal Stromal Cells - drug effects Mesenchyme Nerve growth factor Nerve Growth Factor - pharmacology Original original-article P75NTR Pharmacology/Toxicology Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Polymerase chain reaction Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Stem cells Tibia TrkA protein Vaccine Vascular endothelial growth factor Western blotting 信号通路增殖激活神经生长因子血管内皮生长因子诱导骨髓间质干细胞
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!