Genome methylation in D. melanogaster is found at specific short motifs and is independent of DNMT2 activity

Cytosine methylation in the genome of Drosophila melanogaster has been elusive and controversial: Its location and function have not been established. We have used a novel and highly sensitive genomewide cytosine methylation assay to detect and map genome methylation in stage 5 Drosophila embryos. T...

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Veröffentlicht in:	Genome research 2014-05, Vol.24 (5), p.821-830
Hauptverfasser:	Takayama, Sachiko, Dhahbi, Joseph, Roberts, Adam, Mao, Guanxiong, Heo, Seok-Jin, Pachter, Lior, Martin, David I K, Boffelli, Dario
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Composition CpG Islands Cytosine - metabolism DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methylation Drosophila melanogaster Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Gene Expression Regulation, Developmental Genome, Insect Nucleotide Motifs
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