MicroRNAs in cancer
MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such as inflammation, cell-cycle regulation, stress response, differentiation, apoptosis, and migration. Thus, miRNAs have been...
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| Veröffentlicht in: | Annual review of pathology 2014-01, Vol.9 (1), p.287-314 |
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| container_title | Annual review of pathology |
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| creator | Di Leva, Gianpiero Garofalo, Michela Croce, Carlo M |
| description | MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such as inflammation, cell-cycle regulation, stress response, differentiation, apoptosis, and migration. Thus, miRNAs have been implicated in the regulation of virtually all signaling circuits within a cell, and their dysregulation has been shown to play an essential role in the development and progression of cancer. Here, after a brief description of miRNA genomics, biogenesis, and function, we discuss the effects of miRNA dysregulation in the cellular pathways that lead to the progressive conversion of normal cells into cancer cells and the potential to develop new molecular miRNA-targeted therapies. |
| doi_str_mv | 10.1146/annurev-pathol-012513-104715 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1553-4006 |
| ispartof | Annual review of pathology, 2014-01, Vol.9 (1), p.287-314 |
| issn | 1553-4006 1553-4014 |
| language | eng |
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| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | Animals Apoptosis - genetics Humans MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Neoplasms - drug therapy Neoplasms - genetics RNA, Messenger - genetics Signal Transduction - genetics Transcription, Genetic |
| title | MicroRNAs in cancer |
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