Changes in parotid gland morphology and function in patients treated with intensity-modulated radiotherapy for nasopharyngeal and oropharyngeal tumors
Objective To evaluate the morphological changes of the parotid glands in patients treated with intensity-modulated radiotherapy (IMRT) for nasopharyngeal and oropharyngeal tumors and the correlations with parotid function. Methods Ten patients with nasopharyngeal and oropharyngeal tumors treated wit...
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| Veröffentlicht in: | Oral radiology 2014-05, Vol.30 (2), p.135-141 |
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| creator | Obinata, Kenichi Nakamura, Motoyasu Carrozzo, Marco Macleod, Iain Carr, Andrew Shirai, Shinichi Ito, Hitoshi |
| description | Objective
To evaluate the morphological changes of the parotid glands in patients treated with intensity-modulated radiotherapy (IMRT) for nasopharyngeal and oropharyngeal tumors and the correlations with parotid function.
Methods
Ten patients with nasopharyngeal and oropharyngeal tumors treated with IMRT between May 2009 and January 2010 at Hokkaido University Hospital were included in this study. In the morphological assessment of the parotid glands, the sizes and computed tomography (CT) numbers of the bilateral parotid glands before and after IMRT with CT were calculated. For functional assessment of the parotid glands, we conducted the Saxon test and used a visual analog scale (VAS) for xerostomia evaluation.
Results
Reductions in saliva secretion were observed in the patients treated with IMRT for nasopharyngeal and oropharyngeal tumors, and there was a significant correlation between the reduction in saliva secretion and the VAS. The reductions in the parotid gland size and CT number were larger on the ipsilateral side than on the contralateral side. The reduction in saliva secretion was not significantly correlated with the reduction in parotid gland size, but was significantly correlated with the reduction in CT number.
Conclusions
Morphological and functional changes of the parotid glands were observed after IMRT for nasopharyngeal and oropharyngeal tumors, and preservation of the contralateral parotid glands was only partly achieved. Among the morphological changes of the parotid glands, the CT number may be considered a predictor of parotid function after radiotherapy. |
| doi_str_mv | 10.1007/s11282-013-0151-3 |
| format | Article |
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To evaluate the morphological changes of the parotid glands in patients treated with intensity-modulated radiotherapy (IMRT) for nasopharyngeal and oropharyngeal tumors and the correlations with parotid function.
Methods
Ten patients with nasopharyngeal and oropharyngeal tumors treated with IMRT between May 2009 and January 2010 at Hokkaido University Hospital were included in this study. In the morphological assessment of the parotid glands, the sizes and computed tomography (CT) numbers of the bilateral parotid glands before and after IMRT with CT were calculated. For functional assessment of the parotid glands, we conducted the Saxon test and used a visual analog scale (VAS) for xerostomia evaluation.
Results
Reductions in saliva secretion were observed in the patients treated with IMRT for nasopharyngeal and oropharyngeal tumors, and there was a significant correlation between the reduction in saliva secretion and the VAS. The reductions in the parotid gland size and CT number were larger on the ipsilateral side than on the contralateral side. The reduction in saliva secretion was not significantly correlated with the reduction in parotid gland size, but was significantly correlated with the reduction in CT number.
Conclusions
Morphological and functional changes of the parotid glands were observed after IMRT for nasopharyngeal and oropharyngeal tumors, and preservation of the contralateral parotid glands was only partly achieved. Among the morphological changes of the parotid glands, the CT number may be considered a predictor of parotid function after radiotherapy.</description><identifier>ISSN: 0911-6028</identifier><identifier>EISSN: 1613-9674</identifier><identifier>DOI: 10.1007/s11282-013-0151-3</identifier><identifier>PMID: 24817788</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Dentistry ; Imaging ; Medicine ; Oral and Maxillofacial Surgery ; Original ; Original Article ; Radiology</subject><ispartof>Oral radiology, 2014-05, Vol.30 (2), p.135-141</ispartof><rights>The Author(s) 2013</rights><rights>Japanese Society for Oral and Maxillofacial Radiology and Springer Japan 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-e716432b824aca77ea6fafe73cf59751b1e1ab872e6a322faf22b461c8510e4d3</citedby><cites>FETCH-LOGICAL-c494t-e716432b824aca77ea6fafe73cf59751b1e1ab872e6a322faf22b461c8510e4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11282-013-0151-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11282-013-0151-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24817788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Obinata, Kenichi</creatorcontrib><creatorcontrib>Nakamura, Motoyasu</creatorcontrib><creatorcontrib>Carrozzo, Marco</creatorcontrib><creatorcontrib>Macleod, Iain</creatorcontrib><creatorcontrib>Carr, Andrew</creatorcontrib><creatorcontrib>Shirai, Shinichi</creatorcontrib><creatorcontrib>Ito, Hitoshi</creatorcontrib><title>Changes in parotid gland morphology and function in patients treated with intensity-modulated radiotherapy for nasopharyngeal and oropharyngeal tumors</title><title>Oral radiology</title><addtitle>Oral Radiol</addtitle><addtitle>Oral Radiol</addtitle><description>Objective
To evaluate the morphological changes of the parotid glands in patients treated with intensity-modulated radiotherapy (IMRT) for nasopharyngeal and oropharyngeal tumors and the correlations with parotid function.
Methods
Ten patients with nasopharyngeal and oropharyngeal tumors treated with IMRT between May 2009 and January 2010 at Hokkaido University Hospital were included in this study. In the morphological assessment of the parotid glands, the sizes and computed tomography (CT) numbers of the bilateral parotid glands before and after IMRT with CT were calculated. For functional assessment of the parotid glands, we conducted the Saxon test and used a visual analog scale (VAS) for xerostomia evaluation.
Results
Reductions in saliva secretion were observed in the patients treated with IMRT for nasopharyngeal and oropharyngeal tumors, and there was a significant correlation between the reduction in saliva secretion and the VAS. The reductions in the parotid gland size and CT number were larger on the ipsilateral side than on the contralateral side. The reduction in saliva secretion was not significantly correlated with the reduction in parotid gland size, but was significantly correlated with the reduction in CT number.
Conclusions
Morphological and functional changes of the parotid glands were observed after IMRT for nasopharyngeal and oropharyngeal tumors, and preservation of the contralateral parotid glands was only partly achieved. Among the morphological changes of the parotid glands, the CT number may be considered a predictor of parotid function after radiotherapy.</description><subject>Dentistry</subject><subject>Imaging</subject><subject>Medicine</subject><subject>Oral and Maxillofacial Surgery</subject><subject>Original</subject><subject>Original Article</subject><subject>Radiology</subject><issn>0911-6028</issn><issn>1613-9674</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp1UU2L1TAUDaI4z9Ef4EYCbtxUc5M0STeCPNQRBtzoOqRt-pqhTWqSKu-PzO81bzoOT8FFCPeec8_9OAi9BPIWCJHvEgBVtCLAyquhYo_QDkSJGiH5Y7QjDUAlCFUX6FlKN4TQhnP1FF1QrkBKpXbodj8af7AJO48XE0N2PT5Mxvd4DnEZwxQOR3wKh9V32QW_EbOzPiecozXZ9viXy2MBsvXJ5WM1h36d7oBoehfyaKNZjngIEXuTwjKaeCxNzXSnHOJ5Jq-lcXqOngxmSvbF_X-Jvn_6-G1_VV1__fxl_-G66njDc2UlCM5oqyg3nZHSGjGYwUrWDXUja2jBgmmVpFYYRmnBKG25gE7VQCzv2SV6v-kuazvbvitbRTPpJbq5TKSDcfpvxLtRH8JPzUk5LmuKwJt7gRh-rDZlPbvU2amc0IY1aVBU1A0nlBTq63-oN2GNvqynoaZEgGDkxIKN1cWQUrTDwzBA9Ml1vbmui-v65LpmpebV-RYPFX9sLgS6EVKByp3jWev_qv4Go7m9KQ</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Obinata, Kenichi</creator><creator>Nakamura, Motoyasu</creator><creator>Carrozzo, Marco</creator><creator>Macleod, Iain</creator><creator>Carr, Andrew</creator><creator>Shirai, Shinichi</creator><creator>Ito, Hitoshi</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140501</creationdate><title>Changes in parotid gland morphology and function in patients treated with intensity-modulated radiotherapy for nasopharyngeal and oropharyngeal tumors</title><author>Obinata, Kenichi ; Nakamura, Motoyasu ; Carrozzo, Marco ; Macleod, Iain ; Carr, Andrew ; Shirai, Shinichi ; Ito, Hitoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-e716432b824aca77ea6fafe73cf59751b1e1ab872e6a322faf22b461c8510e4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Dentistry</topic><topic>Imaging</topic><topic>Medicine</topic><topic>Oral and Maxillofacial Surgery</topic><topic>Original</topic><topic>Original Article</topic><topic>Radiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Obinata, Kenichi</creatorcontrib><creatorcontrib>Nakamura, Motoyasu</creatorcontrib><creatorcontrib>Carrozzo, Marco</creatorcontrib><creatorcontrib>Macleod, Iain</creatorcontrib><creatorcontrib>Carr, Andrew</creatorcontrib><creatorcontrib>Shirai, Shinichi</creatorcontrib><creatorcontrib>Ito, Hitoshi</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oral radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Obinata, Kenichi</au><au>Nakamura, Motoyasu</au><au>Carrozzo, Marco</au><au>Macleod, Iain</au><au>Carr, Andrew</au><au>Shirai, Shinichi</au><au>Ito, Hitoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in parotid gland morphology and function in patients treated with intensity-modulated radiotherapy for nasopharyngeal and oropharyngeal tumors</atitle><jtitle>Oral radiology</jtitle><stitle>Oral Radiol</stitle><addtitle>Oral Radiol</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>30</volume><issue>2</issue><spage>135</spage><epage>141</epage><pages>135-141</pages><issn>0911-6028</issn><eissn>1613-9674</eissn><abstract>Objective
To evaluate the morphological changes of the parotid glands in patients treated with intensity-modulated radiotherapy (IMRT) for nasopharyngeal and oropharyngeal tumors and the correlations with parotid function.
Methods
Ten patients with nasopharyngeal and oropharyngeal tumors treated with IMRT between May 2009 and January 2010 at Hokkaido University Hospital were included in this study. In the morphological assessment of the parotid glands, the sizes and computed tomography (CT) numbers of the bilateral parotid glands before and after IMRT with CT were calculated. For functional assessment of the parotid glands, we conducted the Saxon test and used a visual analog scale (VAS) for xerostomia evaluation.
Results
Reductions in saliva secretion were observed in the patients treated with IMRT for nasopharyngeal and oropharyngeal tumors, and there was a significant correlation between the reduction in saliva secretion and the VAS. The reductions in the parotid gland size and CT number were larger on the ipsilateral side than on the contralateral side. The reduction in saliva secretion was not significantly correlated with the reduction in parotid gland size, but was significantly correlated with the reduction in CT number.
Conclusions
Morphological and functional changes of the parotid glands were observed after IMRT for nasopharyngeal and oropharyngeal tumors, and preservation of the contralateral parotid glands was only partly achieved. Among the morphological changes of the parotid glands, the CT number may be considered a predictor of parotid function after radiotherapy.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>24817788</pmid><doi>10.1007/s11282-013-0151-3</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Oral radiology, 2014-05, Vol.30 (2), p.135-141 |
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| source | SpringerLink Journals |
| subjects | Dentistry Imaging Medicine Oral and Maxillofacial Surgery Original Original Article Radiology |
| title | Changes in parotid gland morphology and function in patients treated with intensity-modulated radiotherapy for nasopharyngeal and oropharyngeal tumors |
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