Increased BDNF expression in fetal brain in the valproic acid model of autism

Human fetal exposure to valproic acid (VPA), a widely-used anti-epileptic and mood-stabilizing drug, leads to an increased incidence of behavioral and intellectual impairments including autism; VPA administration to pregnant rats and mice at gestational days 12.5 (E12.5) or E13.5 leads to autistic-l...

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Veröffentlicht in:	Molecular and cellular neuroscience 2014-03, Vol.59, p.57-62
Hauptverfasser:	Almeida, Luis E.F., Roby, Clinton D., Krueger, Bruce K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autism spectrum disorder Autistic Disorder - chemically induced Autistic Disorder - metabolism Brain - drug effects Brain - embryology Brain - metabolism Brain development Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Female Fetus - drug effects Fetus - metabolism Gene promoters Maternal-Fetal Exchange Mice Mice, Inbred C57BL Neurotrophin Pregnancy Receptors, Nerve Growth Factor - genetics Receptors, Nerve Growth Factor - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Valproic Acid - pharmacology Valproic Acid - toxicity VPA
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