Expanding P450 catalytic reaction space through evolution and engineering

•Discovering enzymes for new reactions is important but challenging.•Cytochrome P450 enzymes catalyze many different chemical reactions in nature.•P450s can be engineered to catalyze reactions first discovered by synthetic chemists.•Engineering enhances the activity and selectivity of P450s in non-n...

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Veröffentlicht in:	Current opinion in chemical biology 2014-04, Vol.19, p.126-134
Hauptverfasser:	McIntosh, John A, Farwell, Christopher C, Arnold, Frances H
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysis Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Humans Oxidation-Reduction Protein Engineering
Online-Zugang:	Volltext
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