Stringent response processes suppress DNA damage sensitivity caused by deficiency in full‐length translation initiation factor 2 or PriA helicase

Summary When Escherichia coli grows in the presence of DNA‐damaging agents such as methyl methanesulphonate (MMS), absence of the full‐length form of Translation Initiation Factor 2 (IF2‐1) or deficiency in helicase activity of replication restart protein PriA leads to a considerable loss of viabili...

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Veröffentlicht in:	Molecular microbiology 2014-04, Vol.92 (1), p.28-46
Hauptverfasser:	Madison, K. Elizabeth, Jones‐Foster, Erica N., Vogt, Andrea, Kirtland Turner, Sandra, North, Stella H., Nakai, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriophage mu - genetics Bacteriophage mu - physiology Cells DNA damage DNA Damage - drug effects DNA Helicases - genetics DNA Helicases - metabolism DNA Replication - drug effects E coli Enzymes Escherichia coli Escherichia coli K12 - drug effects Escherichia coli K12 - genetics Escherichia coli K12 - growth & development Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Guanosine Tetraphosphate - pharmacology Methyl Methanesulfonate - pharmacology Mutation Prokaryotic Initiation Factor-2 - genetics Prokaryotic Initiation Factor-2 - metabolism Protein Isoforms - genetics Protein Isoforms - metabolism
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