Biokinetics of nanoparticles and susceptibility to particulate exposure in a murine model of cystic fibrosis

Persons with cystic fibrosis (CF) are at-risk for health effects from ambient air pollution but little is known about the interaction of nanoparticles (NP) with CF lungs. Here we study the distribution of inhaled NP in a murine CF model and aim to reveal mechanisms contributing to adverse effects of...

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Veröffentlicht in:	Particle and fibre toxicology 2014-04, Vol.11 (1), p.19-19
Hauptverfasser:	Geiser, Marianne, Stoeger, Tobias, Casaulta, Marco, Chen, Shanze, Semmler-Behnke, Manuela, Bolle, Ines, Takenaka, Shinji, Kreyling, Wolfgang G, Schulz, Holger
Format:	Artikel
Sprache:	eng
Schlagworte:	Air Pollutants - pharmacokinetics Air Pollutants - toxicity Air Pollution Anatomy & physiology Animals Atoms & subatomic particles Bronchoalveolar Lavage Fluid Carbon monoxide Chemokines Chronic obstructive pulmonary disease Compliance Cystic fibrosis Cystic Fibrosis - pathology Cystic Fibrosis Transmembrane Conductance Regulator - genetics Disease Models, Animal Environmental health Epidemiology Female Females Immunohistochemistry Inhalation Exposure Iridium - pharmacokinetics Iridium - toxicity Iridium Radioisotopes Ligands Lung - drug effects Lung - pathology Lung diseases Lungs Male Mice Mice, Inbred CFTR Mice, Transgenic Microscopy, Electron, Transmission Nanoparticles - toxicity Outdoor air quality Pneumonia - chemically induced Pneumonia - pathology Respiratory Function Tests Respiratory system Rodents Studies Titanium Titanium - toxicity Transmission electron microscopy Variance analysis
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