Activation of AMPK inhibits cardiomyocyte hypertrophy by modulating of the FOXO1/MuRF1 signaling pathway in vitro

Aim： To examine the inhibitory effects of adenosine monophosphate-activated protein kinase （AMPK） activation on cardiac hypertrophy in vitro and to investigate the underlying molecular mechanisms. Methods： Cultured neonatal rat cardiomyocytes were treated with the specific AMPK activator 5-aminoimid...

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Veröffentlicht in:	Acta pharmacologica Sinica 2010-07, Vol.31 (7), p.798-804
Hauptverfasser:	Chen, Bao-lin, Ma, Yue-dong, Meng, Rong-sen, Xiong, Zhao-jun, Wang, Hai-ning, Zeng, Jun-yi, Liu, Chen, Dong, Yu-gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - pharmacology AMP-Activated Protein Kinases - drug effects AMP-Activated Protein Kinases - metabolism AMPK Animals Biomedical and Life Sciences Biomedicine Cardiomegaly - drug therapy Cardiomegaly - enzymology Cells, Cultured Enzyme Activation Forkhead Transcription Factors - metabolism Gene Silencing Immunology Internal Medicine Medical Microbiology Muscle Proteins - metabolism Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Nerve Tissue Proteins - metabolism Original original-article Pharmacology/Toxicology Phenylephrine - pharmacology Pyrazoles - pharmacology Pyrimidines - pharmacology Rats Rats, Sprague-Dawley Ribonucleotides - pharmacology RNA, Small Interfering - administration & dosage Signal Transduction - drug effects Transfection Tripartite Motif Proteins Ubiquitin-Protein Ligases - metabolism Vaccine 体外培养信号通路小干扰RNA 心肌细胞肥大心肌肥厚肌球蛋白重链高效液相色谱法
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