A Novel Role for Coenzyme A during Hydride Transfer in 3‑Hydroxy-3-methylglutaryl-coenzyme A Reductase

In this study, we take advantage of the ability of HMG-CoA reductase (HMGR) from Pseudomonas mevalonii to remain active while in its crystallized form to study the changing interactions between the ligands and protein as the first reaction intermediate is created. HMG-CoA reductase catalyzes one of...

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Veröffentlicht in:	Biochemistry (Easton) 2013-08, Vol.52 (31), p.5195-5205
Hauptverfasser:	Steussy, C. Nicklaus, Critchelow, Chandra J, Schmidt, Tim, Min, Jung-Ki, Wrensford, Louise V, Burgner, John W, Rodwell, Victor W, Stauffacher, Cynthia V
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl Coenzyme A - chemistry Acyl Coenzyme A - genetics Acyl Coenzyme A - metabolism Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Catalysis Catalytic Domain Coenzyme A - chemistry Coenzyme A - metabolism Kinetics Models, Molecular Pseudomonas - chemistry Pseudomonas - enzymology Pseudomonas - genetics
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