Red-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial [ISRCTN42940165]

Isoflavones are hypothesized to protect against breast cancer, but it is not clear whether they act as oestrogens or anti-oestrogens in breast tissue. Our aim was to determine the effects of taking a red clover-derived isoflavone supplement daily for 1 year on mammographic breast density. Effects on...

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Veröffentlicht in:	Breast cancer research : BCR 2004-01, Vol.6 (3), p.R170-R179, Article R170
Hauptverfasser:	Atkinson, Charlotte, Warren, Ruth M L, Sala, Evis, Dowsett, Mitch, Dunning, Alison M, Healey, Catherine S, Runswick, Shirley, Day, Nicholas E, Bingham, Sheila A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - drug effects Aged Anticarcinogenic Agents - isolation & purification Anticarcinogenic Agents - pharmacology Anticarcinogenic Agents - therapeutic use Beans Biomarkers Breast - anatomy & histology Breast - drug effects Clinical trials Connective Tissue - drug effects Double-Blind Method Estradiol Estradiol - blood Female Follicle Stimulating Hormone - blood Follicle-stimulating hormone Genistein - pharmacology Genistein - urine Glycoproteins Hormone therapy Hot Flashes - drug therapy Humans Isoflavones Isoflavones - isolation & purification Isoflavones - pharmacokinetics Isoflavones - pharmacology Isoflavones - therapeutic use Isoflavones - urine Legumes Luteinizing hormone Luteinizing Hormone - blood Lymphocytes Lymphocytes - enzymology Mammography Menopause Menopause - drug effects Middle Aged Mimosaceae Plant Extracts - isolation & purification Plant Extracts - pharmacokinetics Plant Extracts - pharmacology Plant Extracts - therapeutic use Postmenopausal women Protein-Tyrosine Kinases - blood Trifolium - chemistry Tyrosine
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